Syringocystadenocarcinoma papilliferum associated with atypical stroma: A hitherto undocumented variant of sarcomatoid carcinoma

Abstract

Carcinosarcomas are biphasic tumors composed of admixed malignant epithelial and mesenchymal components. Numerous terms have been used to name such neoplasms; therefore, terminological confusion is frequent. Most examples of carcinosarcomas are encountered in non-cutaneous sites, with approximately 100 cases of cutaneous carcinosarcomas reported so far in the English literature. Although different theories have been suggested to explain the occurrence of these peculiar neoplasms, histogenetic mechanisms should be better hypothesized depending on each individual case. Even though prognosis tends to be related to the specific components of the lesion, especially the epithelial one, it seems that cases of cutaneous localization usually have a better outcome. We report an exceedingly rare case of syringocystadenocarcinoma papilliferum which showed an atypical stroma with sarcomatoid appearance, and highlight that the terminology used for this spectrum of lesions is disorganized and confusing.

Nevus Sebaceous of the Scalp With Stepwise Progression Into Invasive Syringocystadenocarcinoma Papilliferum

“…A PubMed literature search revealed—including our newly reported case—53 cases of SCACP (Table 1). 3–6,10–43 SCACP occurred at middle and older ages (range: 22–93 years, median age of 65.5 years). The male to female ratio was 1.3:1 indicating a slight male predominance.…”

A rare case of syringocystadenocarcinoma papilliferum of the breast: An institutional retrospective case review and brief literature review

“…SCACP is a rare entity described predominantly in case reports and small series. [1][2][3][4][5][6][7][8][9][10] To the best of our knowledge, mammary SCACP has not been previously described, and this constitutes the first case of such an unusual presentation.…”