Syringocystadenocarcinoma papilliferum in situ of the penis

Plant, Mathew A; Sade, Shachar; Hong, Collin; Ghazarian, Danny

doi:10.1684/ejd.2012.1723

Cited by 12 publications

(10 citation statements)

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“…Histopathologically, the lesions exhibited “cleft like” acantholysis with full‐thickness atypia, mimicking acantholytic squamous cell carcinoma in situ 16 . Two additional cases of PD with similar features were reported in 2009, 17 and since that time similar findings have been reported in cases of EMPD under various descriptions, including acantholytic anaplastic EMPD, EMPD mimicking acantholytic squamous cell carcinoma in situ, and syringocystadenocarcinoma papilliferum in situ (SCACPIS)‐like change 16‐29 . In addition to the findings of these atypical cases of EMPD with full‐thickness bowenoid atypia and acantholysis, our case also notably overlaps with prior descriptions of SCACPIS, including prominent glandular formation and involvement of adnexal structures with papillations and a plasma‐cell‐rich infiltrate.…”

Section: Discussionsupporting

confidence: 58%

“…SCACPIS is an extremely rare form of cutaneous adenocarcinoma in situ with exceedingly rare reports in the literature 22 . The lesions typically have a warty or exophytic appearance and present in the head and neck region, usually arising from pre‐existing syringocystadenoma (SCP) 18‐23 . Histopathologically, the lesions entirely replace the epidermis and can extend down the adnexa.…”

Section: Discussionmentioning

confidence: 99%

“…Plasma cells are also often present. Lesional cells are typically positive for CK7, EMA, HMFG2, and are variably positive for GCDFP‐15 and CEA 18‐23 . Konstantinova et al described a series of 11 cases of EMPD with histopathologic changes similar to those of SCACPIS; the cases noted demonstrated classic histopathologic appearance of EMPD along with a prominent infiltrate of plasma cells and conspicuous gland formation by lesional cells 20 .…”

Section: Discussionmentioning

confidence: 99%

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Anogenital syringocystadenocarcinoma papilliferum in situ or anaplastic extramammary Paget disease? A unifying concept and review of the literature

Sheldon

Buckley²,

Ulman

et al. 2021

J Cutan Pathol

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Extramammary Paget disease (EMPD) is a rare cutaneous malignancy that typically involves the genital skin and can be primary or associated with an underlying internal malignancy. The typical histopathological appearance of EMPD consists of single or small aggregates of cells with abundant pale cytoplasm and large pleomorphic nuclei, known as Paget cells, scattered throughout the epidermis. We report a case of anogenital EMPD occurring in a 53‐year‐old man with unusual histopathologic findings of marked epidermal acanthosis, acantholysis, intraepidermal glandular differentiation, and prominent plasma cell‐rich fibrovascular cores. These features were entirely confined to the epidermis and adnexa with no evidence of dermal invasion or underlying systemic disease. We review and summarize the literature for atypical features noted in EMPD and summarize similar findings previously described under a variety of descriptions including anaplastic EMPD, anogenital syringocystadenocarcinoma papilliferum in situ (SCACPIS), SCACPIS‐like changes in EMPD, and EMPD mimicking acantholytic squamous cell carcinoma in situ. We propose that these features represent a single entity and be considered under a unifying diagnosis to facilitate recognition of this entity.

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Section: Discussionsupporting

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Anogenital syringocystadenocarcinoma papilliferum in situ or anaplastic extramammary Paget disease? A unifying concept and review of the literature

Sheldon

Buckley²,

Ulman

et al. 2021

J Cutan Pathol

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“…Syringocystadenocarcinoma papilliferum (SCACP) is an exceedingly rare cutaneous adnexal neoplasm, which is listed in the World Health Organization (WHO) classification of skin tumors as the malignant counterpart of syringocystadenoma papilliferum (SCAP). Since the first description in 1980 by Dissanayake and Salm, less than 40 cases have been reported in the literatures till date . Most of them have been published as case reports, with the only large series of 6 cases described by Kazakov et al Most tumors seem to develop over a pre‐existing SCAP, and some were reported to be associated with nevus sebaceus .…”

Section: Introductionmentioning

confidence: 99%

Syringocystadenocarcinoma papilliferum: Clinicopathologic analysis of 10 cases

et al. 2017

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“…The tumour shows pagetoid spread of atypic epithelial cells with numerous mitoses. The tumour was positive for CK5/6, CK7and EMA …”

Section: Malignant Tumoursmentioning

confidence: 99%

Penile tumours: a review

Wollina

Verma²,

Tchernev

2014

Acad Dermatol Venereol

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Penile tumours are an important problem of male health affecting physical, mental and sexual health. Penile tumours can be subdivided into benign and malignant lesions. Their knowledge is important to prevent mutilating surgery in benign lesions. On the other hand, early recognition of malignancies is important for improved prognosis, and preservation of function. The most important tumour by epidemiology and prognosis is penile cancer. In contrast, malignant melanoma, sarcomas and lymphomas are rare. Clinical symptoms, histopathology and treatment options are discussed. Best possible treatment needs an interdisciplinary approach.

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Syringocystadenocarcinoma papilliferum in situ of the penis

Cited by 12 publications

References 0 publications

Anogenital syringocystadenocarcinoma papilliferum in situ or anaplastic extramammary Paget disease? A unifying concept and review of the literature

Anogenital syringocystadenocarcinoma papilliferum in situ or anaplastic extramammary Paget disease? A unifying concept and review of the literature

Syringocystadenocarcinoma papilliferum: Clinicopathologic analysis of 10 cases

Penile tumours: a review

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