Syringocystadenocarcinoma papilliferum: Clinicopathologic analysis of 10 cases

Zhang, Yan; Kong, Yunyi; Cai, Xu; Shen, Xueyan; Kong, Jincheng

doi:10.1111/cup.12934

Cited by 24 publications

(45 citation statements)

References 34 publications

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“…Other reported histopathologic findings in this adnexal adenocarcinoma include intraepidermal and intrafollicular pagetoid spread, so‐called “dirty necrosis”, mucinous ductal metaplasia and ductal changes analogous to those seen in the breast. A recent study supported that the biological behavior of syringocystadenocarcinoma papilliferum seems to be more aggressive than previously reported …”

Section: Introductionsupporting

confidence: 74%

Syringocystadenocarcinoma papilliferum associated with atypical stroma: A hitherto undocumented variant of sarcomatoid carcinoma

2019

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Carcinosarcomas are biphasic tumors composed of admixed malignant epithelial and mesenchymal components. Numerous terms have been used to name such neoplasms; therefore, terminological confusion is frequent. Most examples of carcinosarcomas are encountered in non-cutaneous sites, with approximately 100 cases of cutaneous carcinosarcomas reported so far in the English literature. Although different theories have been suggested to explain the occurrence of these peculiar neoplasms, histogenetic mechanisms should be better hypothesized depending on each individual case. Even though prognosis tends to be related to the specific components of the lesion, especially the epithelial one, it seems that cases of cutaneous localization usually have a better outcome. We report an exceedingly rare case of syringocystadenocarcinoma papilliferum which showed an atypical stroma with sarcomatoid appearance, and highlight that the terminology used for this spectrum of lesions is disorganized and confusing.

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Section: Introductionsupporting

confidence: 74%

Syringocystadenocarcinoma papilliferum associated with atypical stroma: A hitherto undocumented variant of sarcomatoid carcinoma

2019

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“…WLE has been the mainstay treatment for localized SCACP; however, high recurrence rate (30-40%) following surgery has been reported [ 4 , 6 ]. For unresectable or metastatic disease, no standard treatment has yet been established.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Syringocystadenocarcinoma Papilliferum: A Case Report, Tumor Genomic Profiling, and Literature Review

Altunel

Perepletchikov

Kozyreva

2020

Case Reports in Oncological Medicine

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Syringocystadenocarcinoma papilliferum (SCACP) is an extremely rare cutaneous neoplasm of the apocrine or eccrine sweat glands. Solid and cystic glandular structures with cribriform and tubular architecture along with CK5/6, pankeratin and p63 immuno-profile set apart SCACP from other cutaneous malignancies. Wide local excision (WLE) has been the mainstay treatment for localized SCACP; however, no standard treatment has yet been established for unresectable or metastatic disease. Herein, we report a 74-year-old male with SCACP, who initially presented with a painful nodule on the upper back and later developed metastatic disease. He was treated with carboplatin and paclitaxel with concurrent intensity-modulated radiation therapy (IMRT), which resulted in disease stabilization for 12 months. Next generation sequencing (NGS) revealed a total of 18 genomic alterations associated with potential benefit from targeted therapeutics. PD-L1 expression was identified in 70% of tumor cells. These findings suggest that the opportunity of targeted therapeutics and immunotherapy exist as for metastatic SCACP. Reporting molecular profile of the rare tumors with no established standard treatment options should be encouraged.

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“…The invaginations and papillary projections are lined by two-layer epithelium: the luminal layer composed of columnar cells with decapitation secretions and the outer layer composed of small cuboidal cells. The immunohistochemical features of SCACP are still under study, but the most frequently reported markers are CEA, 15,20,28 followed by EMA, 9,28 GDFP-15, 20,28,32 and cytokeratin. 11,28,32 Due to its appearance, the differential diagnosis includes other skin tumors such as basal cell carcinoma, squamous cell carcinoma, sebaceous carcinoma, metastatic breast or gastrointestinal adenocarcinomas, and other sweat gland neoplasms.…”

Section: Discussionmentioning

confidence: 99%

“…The immunohistochemical features of SCACP are still under study, but the most frequently reported markers are CEA, 15,20,28 followed by EMA, 9,28 GDFP-15, 20,28,32 and cytokeratin. 11,28,32 Due to its appearance, the differential diagnosis includes other skin tumors such as basal cell carcinoma, squamous cell carcinoma, sebaceous carcinoma, metastatic breast or gastrointestinal adenocarcinomas, and other sweat gland neoplasms. 2,20 Of the cases that reported head and neck involvement, 16 (72.72%) were in remission following therapy, 2 (9.09%) had local recurrence, 3 (13.63%) had regional lymphatic invasion, and 1 (4.54%) had distant metastases.…”

Section: Discussionmentioning

confidence: 99%

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Syringocystadenocarcinoma papilliferum with orbital invasion: a case report with literature review

et al. 2019

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We present a case of Syringocystadenocarcinoma papilliferum that originated in the eyelid and extended into the orbit. These tumors are very rare and have the potential to metastasize. A literature review of all the previous cases has been compiled from the Medline, EMBASE, and PubMed databases. We found that the majority of cases present on the head and neck and up to 17% of cases showed metastatic progression. This is the first case to show orbital involvement and highlights the need to remain vigilant with such lesions, as they have a tendency to become aggressive.

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Syringocystadenocarcinoma papilliferum: Clinicopathologic analysis of 10 cases

Abstract: Because of high rates of regional lymph node metastasis and mortality in our patients, clinical behavior of SCACP seems to be more aggressive than that previously reported.

Cited by 24 publications

References 34 publications

Syringocystadenocarcinoma papilliferum associated with atypical stroma: A hitherto undocumented variant of sarcomatoid carcinoma

Syringocystadenocarcinoma papilliferum associated with atypical stroma: A hitherto undocumented variant of sarcomatoid carcinoma

Metastatic Syringocystadenocarcinoma Papilliferum: A Case Report, Tumor Genomic Profiling, and Literature Review

Syringocystadenocarcinoma papilliferum with orbital invasion: a case report with literature review

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