Syringoid Eccrine Carcinoma

Weber, Paul J.; Gretzula, C D O Joseph; Garland, Larry D.; Hevia, B S Oscar; Menn, Henry

doi:10.1111/j.1524-4725.1987.tb00498.x

Cited by 31 publications

(17 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Knowledge of disease characteristics and prognosis is based on case reports and small retrospective series that broadly group together rare malignant cutaneous neoplasms including apocrine, eccrine, follicular, and sebaceous carcinomas [5][6][7][8][9][10][11]. While there are limited series that describe individual subtypes of eccrine tumors, prognostic factors and definitive therapeutic strategies have not been established [12][13][14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Survival after resection of cutaneous adnexal carcinomas with eccrine differentiation: Risk factors and trends in outcomes

Avraham

Villines

Maker

et al. 2013

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Survival after resection of cutaneous adnexal carcinomas with eccrine differentiation: Risk factors and trends in outcomes

Avraham

Villines

Maker

et al. 2013

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

“…A review of the literature indicates a high rate of local recurrence (10%-70%) 2,3 and subsequent metastasis (up to 60%) 4 following conventional surgical excision of these tumors (Table 1). [5][6][7] Although the utility of Mohs micrographic surgery has been well documented for microcystic adnexal carcinoma, experience with other subtypes is limited. A propensity for poorly circumscribed growth and anatomically challenging locations such as the head and neck (microcystic adnexal carcinoma, hidradenocarcinoma) and acral locations (eccrine porocarcinoma) suggests that Mohs micrographic surgery may result in tissue sparing and decreased recurrence.…”

mentioning

confidence: 99%

Mohs Surgery for Malignant Eccrine Neoplasms

2004

View full text Add to dashboard Cite

show abstract

“…A few convincing examples of SEC have been reported since the initial report by Freeman and Winkelmann in 1969. 1 To our knowledge, 35 cases have been reported under the name of SEC, [2][3][4][5][6][7][8][9][10][11][12][13] sweat gland carcinoma with syringomatous features, 14 and eccrine epithelioma. 1,[15][16][17][18][19] Most of the lesions (19 cases) showed infiltrating plaques occurring on the scalp, 1-3,5-8,10,11,13,15,16,18 while eight cases were located on the extremities, 2,4,9,17,19 two cases on the back 2 and cheek, 2,6 and one case each on the ear, 2 eyebrow, 8 neck, 1 upper lip, 19 thorax, 12 and abdomen.…”

Section: Discussionmentioning

confidence: 99%

“…8 The lesions were of several years' duration (4 months to 40 years) and measured 1-11 cm in diameter. [1][2][3]5,[8][9][10][11][12][13][14][15][16][17][18][19] The majority of lesions run an indolent course which may be complicated by local recurrence. 1,2,4,6,8,15,17 Metastasis to regional lymph nodes and subsequently to the bones has been reported in only one case.…”

Section: Discussionmentioning

confidence: 99%

Syringoid eccrine carcinoma with apparently aggressive transformation: case report and review of the literature

Nishizawa¹,

Nakanishi²,

Sasajima³

et al. 2006

Int J Dermatol

View full text Add to dashboard Cite

A 65‐year‐old man presented with a 20‐year history of a lesion on his lower abdomen. The lesion had started as an indolent papule that slowly developed to form an extensive plaque. Physical examination revealed a flat‐topped, elevated, well‐demarcated, erythematous plaque measuring 7 cm × 5 cm in diameter (Fig. 1). The lesion had an elastic, hard induration beneath the plaque and was fixed to the underlying tissue. Inguinal lymphadenopathy was present. Hematologic and biochemical investigations were all within the normal ranges. The patient underwent incision biopsy. 1 Clinical appearance of the lesion. An indurated plaque can be seen on the lower abdomen A biopsy specimen, measuring 2.7 cm, revealed that the tumor was located in the dermis, and consisted of solid nests and small cords in a dense fibrocollagenous stroma. The tumor located in the upper dermis consisted mainly of solid nests with calcified central necrosis (Figs 2 and 3). The tumor located in the deep dermis consisted of small cords forming luminal, tubular, and tadpole‐shaped structures, resembling those of syringoma (Figs 2 and 3). Solid tumor nests consisted of tumor cells which were basaloid and polymorphic, with hyperchromatic nuclei. A few mitotic figures were observed. A palisading arrangement of tumor cells was not observed at the periphery of the solid tumor nests. Keratinous cysts and follicular differentiation were not observed. No apocrine differentiation, such as decapitation secretion, was observed. There were no connections between the tumor nests and the epidermis. The extent of tumor invasion could not be determined from the biopsy specimen because the tumor had spread beyond the edges of the excision. Immunohistochemical analysis showed diffuse nuclear and cytoplasmic positivity for S‐100 protein (1 : 1000; Dakopatts, Glostrup, Denmark) and focal positivity for carcinoembryonic antigen (CEA, 1 : 500; Mochida, Tokyo, Japan). 2 The tumor consisted of solid undifferentiated nests and small cords forming tubular structures in a dense fibrocollagenous stroma (original magnification, ×40) 3 The tumor located in the upper dermis consisted mainly of solid undifferentiated nests with calcified central necrosis. Small cords forming tubular structures resembling those of syringoma can also be observed (original magnification, ×200) The extent of tumor spread was evaluated by computed tomography (CT) and magnetic resonance imaging. The primary tumor had infiltrated the rectus abdominis muscle, and multiple metastases, up to 1 cm in diameter, were observed in the lungs, right bronchus, para‐aortic lymph nodes and Th11, right S1, and bilateral ilium. CT scan revealed no continuity between the tumor and the prostate. After consulting a urologist, the possibility of prostate cancer was ruled out. After diagnosis and evaluation of tumor spread, the patient was treated with seven cycles of combination chemotherapy as follows: 5‐fluorouracil (350 mg/m2 intravenously) on days 1–5, epirubicin (40 mg/m2 intravenously) on day 1, mitomycin C (3....

show abstract

Syringoid Eccrine Carcinoma

Abstract: Syringoid eccrine carcinomas (SECs) are rare adnexal neoplasms that may display aggressive local recurrence and occasional metastases. This report describes three cases of SEC treated by Mohs micrographic surgery.

Cited by 31 publications

References 17 publications

Survival after resection of cutaneous adnexal carcinomas with eccrine differentiation: Risk factors and trends in outcomes

Survival after resection of cutaneous adnexal carcinomas with eccrine differentiation: Risk factors and trends in outcomes

Mohs Surgery for Malignant Eccrine Neoplasms

Syringoid eccrine carcinoma with apparently aggressive transformation: case report and review of the literature

Contact Info

Product

Resources

About