Syringoid eccrine carcinoma: a clinicopathological and immunohistochemical study of four cases

Abstract

SEC can present on the trunk and are not limited to the head and neck region. In addition to syringoma-like tadpole structures and glandular differentiation, these tumours can also exhibit squamoid and cribriform growth patterns. Immunostaining in SEC is variable and this variability is believed to stem from this tumour's ability to differentiate along multiple routes, including sweat secretory and/or ductal differentiation.

Ductal eccrine carcinoma of the axilla: a diagnostic pitfall

“…It has a predilection for the head and neck, although cases on the trunk and extremities have also been described, and occurs mostly in middle-aged to elderly adults of both sexes. 1,2,4,5 …”

“…3,8 The stroma is characteristically desmoplastic and perineural and lymphovascular invasion are commonly present. 4,7,8 …”

“…They may also express estrogen and progesterone receptors, CEA, c-erbB-2, S-100, and GCDFP-15 to varying degrees. 2,4,9 …”

“…1-3 It is more frequently located on the head and neck, but cases on the trunk and extremities have also been described. 4 Because of its striking histologic homology to invasive breast carcinoma, differential diagnosis can be challenging, particularly on unusual anatomic sites such as the breast or axilla. 2,5-7 We report a case of DEC of the axilla with associated axillary lymph node metastases.…”

Metastatic syringoid eccrine carcinoma of the nipple

“…SEC can occur in the head and neck region and less commonly on the trunk 2. Histologically, it is characterized by a syringoma-like tadpole morphology composed of basaloid cells with ductal differentiation within a fibrocollagenous matrix.…”