Syringoid Eccrine Carcinoma of the Foot: Report of a Rare Cutaneous Adnexal Neoplasm

Abstract

Syringoid eccrine carcinoma is a rare malignant adnexal tumor that typically presents in the head and neck region. Involvement of the extremities is uncommon, with only a few cases reported in the literature. Here, we report our experience with a rare case of syringoid eccrine carcinoma occurring on the plantar surface of the right foot in a 47-year-old African American woman. Histologically, incisional biopsy revealed a tumor consisting of tubulocystic structures lined by basaloid cells with an infiltrative growth pattern, extending from the reticular dermis to the deep biopsy margin. Some of the nests and cords of basaloid cells displayed syringoma-like, tadpole morphology. Immunohistochemical analysis showed diffuse immunoreactivity with monoclonal carcinoembryonic antigen, epithelial membrane antigen, cytokeratin 7, S100 protein, and CD117. These morphologic and immunophenotypic features were most consistent with syringoid eccrine carcinoma. Syringoid eccrine carcinoma has a broad differential diagnosis which must be carefully ruled out by morphology, immunohistochemistry, and thorough metastatic survey with imaging studies. Our case highlights the importance of recognizing this rare entity, which is locally destructive and has a propensity for recurrence. To the best of our knowledge, this is the first reported case of syringoid eccrine carcinoma presenting on the sole of the foot.

Syringoid Eccrine Carcinoma in the Abdominal Wall: A Rare Case Report and Literature Review

“…In the differential diagnosis with ADC, perineural infiltration and histological presentation might resemble ADC with a cribriform morphological pattern; however, the positivity for CEA and S100 in our patient would be more consistent with the tubular pattern [21]. Thus, in addition to the immunohistochemical pattern disagreeing with the morphological pattern, there is no accumulation of mucin, as occurs in ADC, favoring the diagnosis of SEC [3,14,19,17]. Imaging studies have been reported to be important but for delimiting the lesion, but not for diagnosis of SEC [11], or searching for metastases [9,10,15].…”

“…Tumor cells can organize into nests, cords, or tubules, some of which exhibit a morphology resembling tadpole-like syringoma due to the cords of epithelial tissue. Cytonuclear atypia is not very evident, as is the presence of mitotic activity, which may even be absent [1,11,14,16]. The epithelial component of the tumor may show a cribriform pattern in focus (Figure 3), which makes it difficult to distinguish from other tumors [3].…”

Eccrine and Apocrine Carcinoma in Dogs

“…O carcinoma écrino (CE) é um neoplasma maligno raro das glândulas sudoríparas que pode acometer cães, gatos [7] e humanos. Em pessoas o CE tem maior frequência em cabeça e pescoço, podendo ocorrer metástase para qualquer parte do corpo [10] e, geralmente, se manifesta a partir da meia idade [2].…”

“…Em ambos os casos, os fragmentos excisados foram acondicionados em solução de formalina tamponada a 10% e processados rotineiramente, incluídos em parafina, cortados a 4 µm, corados com hematoxilina (Hematoxilina de Harris) 1 e eosina (Eosina Amarelada -Ci45380) 2 , seguidos de avaliação histopatológica.…”