Syringomatous Adenoma of the Nipple: Report of a Case

Abstract

We report herein a rare case of syringomatous adenoma (SA) of the nipple. Only 22 cases of SA of the nipple have been documented in the world literature, and to the best of our knowledge this is the first case to be reported in Japan. The patient was a 68-year-old woman who presented with a painful mass in the right subareolar region of over 15 years' duration. Clinical examination including needle biopsy indicated a high possibility of carcinoma; however, the final histopathological diagnosis after mastectomy proved to be SA. SA is a benign locally infiltrating neoplasm of the nipple which shares many clinicopathological features with adenoma of the nipple. Both lesions sometimes show deceptive clinicopathological findings, causing then to be easily confused with carcinomas. However, SA can be distinguished by its unique histological appearance resembling sweat duct, or syringomatous, tumors and locally infiltrating growth, which is probably responsible for its misleading clinical findings and higher rate of recurrence. Surgeons should be aware of the possibility of diagnosing this extremely rare tumor, and the appropriate treatment.

Rare benign tumours of the nipple

“…The references of the papers were reviewed and all relevant articles were also examined (total 43). Different entities that were described included: neurofibroma, 5-7 leiomyoma, [8][9][10][11][12][13][14][15][16][17][18] milium, 19,20 florid papillomatosis, 9,[21][22][23][24][25][26][27] syringomatous adenoma, [28][29][30][31][32] nevoid hyperkeratosis, [33][34][35][36][37][38][39][40][41] fibroma, 42,43 pseudolymphoma and [44][45][46][47] hemangioma. 9 Table 1 summarizes the papers for each entity.…”

Syringomatous adenoma of the nipple occurring within a supernumerary breast: a case report

“…These tumors are usually amenable to local excision, and they can persist or recur if incompletely excised. Relative few cases have been reported in the world literature (about 30), and no reports exist, to our knowledge, of any of these lesions occurring in a supernumerary breast 10,14–23 …”

Syringomatous Adenoma of the Nipple-Treatment by Central Mound Resection and Oncoplastic Reconstruction

“…MAC was first described in 1982; it is a slow‐growing, locally infiltrative cutaneous neoplasm with a predilection to the face. Histologically, it consists primarily of nests and cysts of cytologically uniform squamous cells, but some have a ductal component (6). In SA, the ducts are relatively uniform, but in MAC they often have a papillary appearance or a complex tubuloalveolar component (6).…”

“…They generally arise in the nipple and subsequently involve the underlying breast parenchyma (2). There have been a total of 31 cases reported in the English literature (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). All but one case occurred in females with an age range of 11-76 years.…”