System Dynamic Model Simulates the Growth Trend of Diabetes Mellitus in Chinese Population: Implications for Future Urban Public Health Governance

Li, Hao; Chang, Guo-Ying; Jiang, Yihong; Xu, Li; Shen, Long; Z, Gu; Lin, Hou‐Wen; Shi, Fang-Hong

doi:10.3389/ijph.2022.1605064

Cited by 13 publications

(11 citation statements)

References 47 publications

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“…NPTN-IT1 is a recently identified lncRNA, located on chromosome 15q24.1, which has a low expression level in tumor tissues and can inhibit the growth and metastasis of hepatocellular carcinoma, lung adenocarcinoma (Yang et al, 2013;Liu et al, 2016), nasopharyngeal carcinoma and cervical cancer (Jiang et al, 2015;Sun et al, 2015). LINC02362 is associated with better prognosis of HCC patients, and inhibits the survival, migration and invasion of HCC cells and epithelial interstitial transformation (EMT) (Li et al, 2022b). Although there is no relevant study on the above lncRNANs in diabetes, it is well known that hypoxia is an important feature of tumor microenvironment, and the above lncRNAN regulates tumor growth through hypoxia related pathways, and may also affect glucose metabolism through hypoxia related pathways.…”

Section: Discussionmentioning

confidence: 99%

Identification and analysis of hub genes of hypoxia-immunity in type 2 diabetes mellitus

Yan

et al. 2023

Front. Genet.

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The chronic metabolic disease named type 2 diabetes (T2D) accounts for over 90% of diabetes mellitus. An increasing number of evidences have revealed that hypoxia has a significantly suppressive effect on cell-mediated immunity, as well as the utilization of glucose in diabetics. Therefore, we aimed to screen and identify hypoxia-immune-related hub genes in T2D through bioinformatic analysis. The Gene Expression Omnibus (GEO) database was used to get T2D gene expression profile data in the peripheral blood samples (GSE184050), and hypoxia-related genes were acquired from Molecular Signatures Database (MSigDB). Differentially expressed mRNAs (DEGs) and lncRNAs (DELs) between T2D and normal samples were identified by DeSeq2 package. The clusterProfiler package was used to perform enrichment analyses for the overlapped genes of DEGs and hypoxia-related genes. Further, Hypoxia-related hub genes were discovered using two machine learning algorithms. Next, the compositional patterns of immune and stromal cells in T2D and healthy groups were estimated by using xCell algorithm. Moreover, we used the weighted correlation network analysis (WGCNA) to examine the connection between genes and immune cells to screen immune-related genes. Gene Set Enrichment Analysis (GSEA) was used to investigate the functions of the hypoxia-immune-related hub genes. Finally, two peripheral blood cohorts of T2D (GSE184050 and GSE95849) as well as the quantitative real-time PCR (qRT-PCR) experiments for clicinal peripheral blood samples with T2D were used for verification analyses of hub genes. And meanwhile, a lncRNA-TF-mRNA network was constructed. Following the differentially expressed analysis, 38 out of 3822 DEGs were screened as hypoxia-related DEGs, and 493 DELs were found. These hypoxia-related DEGs were mainly enriched in the GO terms of pyruvate metabolic process, cytoplasmic vesicle lumen and monosaccharide binding, and the KEGG pathways of glycolysis/gluconeogenesis, pentose phosphate pathway and biosynthesis of nucleotide sugars. Moreover, 7 out of hypoxia-related DEGs were identified as hub genes. There were six differentially expressed immune cell types between T2D and healthy samples, which were further used as the clinical traits for WGCNA to identify AMPD3 and IER3 as the hypoxia-immune-related hub genes. The results of the KEGG pathways of genes in high-expression groups of AMPD3 and IER3 were mainly concentrated in glycosaminoglycan degradation and vasopressin-regulated water reabsorption, while the low-expression groups of AMPD3 and IER3 were mainly associated with RNA degradation and nucleotide excision repair. Finally, when compared to normal samples, both the AMPD3 and IER3 were highly expressed in the T2D groups in the GSE184050 and GSE95849 datasets. The result of lncRNA-TF-mRNA regulatory network showed that lncRNAs such as BACH1-IT1 and SNHG15 might induce the expression of the corresponding TFs such as TFAM and THAP12 and upregulate the expression of AMPD3. This study identified AMPD3 and IER3 as hypoxia-immune-related hub genes and potential regulatory mechanism for T2D, which provided a new perspective for elucidating the upstream molecular regulatory mechanism of diabetes mellitus.

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Section: Discussionmentioning

confidence: 99%

Identification and analysis of hub genes of hypoxia-immunity in type 2 diabetes mellitus

Yan

et al. 2023

Front. Genet.

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“…Implementing appropriate interventions has the potential to effectively delay this progression. [6] Sodium glucose cotransporter type 2 (SGLT2) inhibitors represent a new class of antidiabetic medications for the treatment of diabetes, and act inhibits renal glucose reabsorption, thereby increasing urinary glucose excretion and lowering the glucose burden on the organism. [7][8][9] Since SGLT2 inhibitors have been extensively studied and demonstrated to significantly reduce cardiovascular events such as HF and myocardial infarction.…”

Section: Introductionmentioning

confidence: 99%

Effect of dapagliflozin on left ventricular structure and function in patients with non-ischemic dilated cardiomyopathy: An observational study

Hong,

Huang,

Jin

et al. 2024

Medicine

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Non-ischemic dilated cardiomyopathy (NIDCM) is characterized by left ventricular dilatation and contractile dysfunction with severe morbidity and mortality. Sodium glucose cotransporter type 2 (SGLT2) inhibitors significantly reduce cardiovascular events for heart failure patients. We performed to investigate the impact of combined administration of SGLT2 inhibitors on cardiac structure and function in NIDCM patients undergoing conventional therapy. A total of 50 newly diagnosed NIDCM patients received conventional medical therapy, with 23 receiving dapagliflozin 10mg/day in addition (SGLT2i group) and the remaining 27 only receiving conventional therapy (non-SGLT2i group). After 12 months outpatient follow-up, NIDCM patients treated with conventional therapy alone showed a significant reduction of left ventricular end-diastolic dimensions (LVEDd), left ventricular end-systolic dimensions (LVESd), left ventricular end-diastolic volumes (LVEDV), left ventricular end-systolic volumes (LVESV), left ventricular end-diastolic volume index (LVEDVi) and left ventricular end-systolic volume index (LVESVi), while an increase in fractional shortening (FS) and left ventricular ejection fraction (LVEF). Patients receiving dapagliflozin combined with conventional treatment also demonstrated a significant reduction in left ventricular dimensions and volumes, and a marked increase in cardiac function. In non-SGLT2i groups, the % change in LVEDd, LVESd, LVEDV, LVESV, LVEDVi, LVESVi, FS and LVEF was −2.8%, −4.6%, −6.2%, −10.1%, −6.1%, −10.1%, +9.7%, +11%. A greater absolute % fall in left ventricular volume in SGLT2i groups compared to non-SGLT2i groups resulted in a significant improvement in cardiac function. The results showed that SGLT2i combined with conventional therapy has a better beneficial effect on left ventricular volumes and cardiac function in NIDCM patients.

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“…It has been reported that the diabetes prevalence among Chinese adults has already exceeded 10%, and it is still on the rise, with an estimated increase to 202.84 million patients by 2050. [4] Existing treatment methods mainly include medication, laser therapy, and surgical intervention. However, these treatments have their limitations.…”

Section: Introductionmentioning

confidence: 99%

Influence of continuous 4C nursing on quality of life and self-care ability of patients with diabetes retinopathy: An observational study

Wufuer,

Ma,

Ainiwa

et al. 2024

Medicine

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This study aims to investigate the impact of continuous 4C nursing on patients with diabetes retinopathy (DR) and its influence on self-care ability. A total of 100 DR patients admitted to our hospital from October 2020 to October 2022 were randomly divided into a control group and an observation group, with 50 cases in each group. The control group received routine care, while the observation group received continuous 4C care. The nursing effects of both groups were compared. After nursing, the observation group showed a lower self-rating anxiety scale score and a higher self-care ability scale score compared to the control group (P < .05). The SQQL-VI scores for all social activities were also higher in the observation group (P < .05). Additionally, the observation group had lower levels of fasting blood glucose, 2-hour postprandial blood glucose, and glycated hemoglobin than the control group (P < .05). Moreover, the observation group had higher visual acuity and lower intraocular pressure than the control group (P < .05). The visual impairment rate was lower and the overall compliance rate was higher in the observation group compared to the control group (P < .05). After nursing, both groups showed improvements in symptoms, visual function, physical function, psychological and social activity scores, visual acuity, and patient satisfaction scores. The observation group showed greater improvements compared to the control group (P < .05). The application of continuous 4C nursing in DR patients has shown positive effects, including improved patient compliance and satisfaction, enhanced patient quality of life and visual acuity. These findings suggest that continuous 4C nursing should be widely promoted and applied in clinical practice.

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System Dynamic Model Simulates the Growth Trend of Diabetes Mellitus in Chinese Population: Implications for Future Urban Public Health Governance

Cited by 13 publications

References 47 publications

Identification and analysis of hub genes of hypoxia-immunity in type 2 diabetes mellitus

Identification and analysis of hub genes of hypoxia-immunity in type 2 diabetes mellitus

Effect of dapagliflozin on left ventricular structure and function in patients with non-ischemic dilated cardiomyopathy: An observational study

Influence of continuous 4C nursing on quality of life and self-care ability of patients with diabetes retinopathy: An observational study

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