Computational Fluid Dynamics codes are increasingly used to simulate containment conditions after various transient accident scenarios. This paper presents validation experiments, conducted in the frame of the OECD/SETH-2 project. These experiments address the combined effects of mass sources and heat sinks related to gas mixing and hydrogen transport within containment compartments. A wall jet interacts with an operating containment cooler located in the middle (M-configuration) and the top (T-configuration) of the containment vessel. The experiments are characterized by a 3-phase injection scenario. In Phase I, pure steam is injected, while in Phase II, a helium-steam mixture is injected. Finally, in Phase III, pure steam is injected again. Results for the M-configuration show helium stratification build up during Phase II. During Phase III, a positively buoyant plume emerging from the cooler housing becomes negatively buoyant once it reaches the helium-steam layer and continuously erodes the layer. For the M-configuration, a strong degradation of the cooler performance was observed during the injection of the helium/steam mixture (Phase II). For the T-configuration, we observe a mainly downwards acting cooler resulting in a combination of forced and natural convection flow patterns. The cooler performance degradation was much weaker compared with the M-configuration and a good mixing was ensured by the operation of the cooler.