Systematic and Model-Assisted Evaluation of Solvent Based- or Pressurized Hot Water Extraction for the Extraction of Artemisinin from Artemisia annua L.

Abstract

Abstract:In this study, the solvent based extraction of artemisinin from Artemisia annua L. using acetone in percolation mode is compared to the method of pressurized hot water extraction. Both techniques are simulated by a physico-chemical process model. The model as well as the model parameter determination, including the thermal degradation of artemisinin are shown and discussed. For the conventional extraction, a solvent screening is performed considering various organic solvents. A temperature screening is presented for the systematic design of the pressurized hot water extraction. The best temperature with regards to thermal decomposition and high productivity was found to be 80 • C. Both, conventional percolation and Pressurized Hot Water Extraction (PHWE) are suitable for the extraction of artemisinin. The extraction curves show a high conformity with the simulation results.

A review on the latest advances in extraction and analysis of artemisinin

“…Artemisinin ( 1 ) extraction from A. annua based on systematic and model‐assisted process design, which was established from laboratory‐scale experiments and miniplant‐scale pilot, were reported . Artemisinin ( 1 ) was extracted from A. annua by conventional percolation using acetone, and pressurised hot water extraction was performed at 80°C to extract artemisinin ( 1 ) . In both cases, a systematic and model‐assisted process design was used aiming at defining resource‐efficient and economic processes.…”

“…ultrasoundassisted extraction, utilising various computational tools and mathematical modelling, has been observed in recent years. During the period from 2017 to present, several protocols of ultrasound-assisted extraction and SFE of artemisinin (1) have been reported (Table 1), [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] which will be discussed briefly in the following subsections.…”

“…8 Artemisinin (1) was extracted from A. annua by percolation using acetone. 9 Pressurised hot water extraction was performed at 80°C to extract artemisinin (1) from A. annua. 9 Extraction using Hansen solubility parameters in practice approach Isopropanol was used for artemisinin (1) extraction from A. annua with the yield of 65%.…”

“…9 Pressurised hot water extraction was performed at 80°C to extract artemisinin (1) from A. annua. 9 Extraction using Hansen solubility parameters in practice approach Isopropanol was used for artemisinin (1) extraction from A. annua with the yield of 65%. 10 Mechanochemical extraction using deep eutectic solvents A high-throughput analytical method employing deep eutectic solvents for mechanochemical extraction combined with direct analysis in real time mass spectrometry (DART-MS) was developed to quantify thermolabile artemisinin (1) and related components of A. annua.…”

“…Artemisinin (1) (1) was extracted from A. annua by conventional percolation using acetone, and pressurised hot water extraction was performed at 80°C to extract artemisinin (1). 9 In both cases, a systematic and model-assisted Laboukhi-Khorsi et al 10 reported the extraction method using…”