Systematic evaluation of the anti-tumor effect of Phellinus linteus polysaccharide in thyroid carcinoma in vitro

Yu, Kun; Tan, Zhuo; Xin, Ying

doi:10.1007/s11033-021-07090-6

Cited by 7 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, P. linteus is a well-known medicinal mushroom that contains a number of bioactive compounds, including polyphenols, terpenoids, furans and polysaccharides. Previous studies have reported that extracts from fruiting bodies or cultured mycelium can exhibit numerous bioactivities, such as anticancer, anti-inflammation, immunomodulatory, antioxidant and antidiabetic effects (14)(15)(16)(17)(18). Therefore, Smilax corbularia and Phellinus linteus were the plant and fungi of interest in this study.…”

Section: Introductionmentioning

confidence: 99%

In vitro antioxidant and anticancer activities of Smilax corbularia extract combined with Phellinus linteus extract against breast cancer cell lines

Syukriya,

Bankeeree,

Prasongsuk

et al. 2023

Biomed Rep

View full text Add to dashboard Cite

Treatment with extracts from whole herbs has been reported to synergistically enhance the anticancer activities of therapeutic agents in recent studies. The present study evaluated the antioxidant and anticancer activities of Smilax corbularia Kunth ( S. corbularia ) and Phellinus linteus ( P. linteus ) crude extracts individually and in combination. S. corbularia was extracted using ethanol, whereas P. linteus was extracted using hot water. Both crude extracts underwent physiochemical characterization. Subsequently, the possible antioxidant activities of both crude extracts, individually and in combination, were evaluated using 2,2-Diphenyl-1-picrylhydrazyl and 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) assays. Their effects on breast cancer cell cytotoxicity, proliferation and apoptosis were then assessed. The crude S. corbularia extract obtained was found to have a high level of total phenolic content, whilst the crude P. linteus extract had high levels of total polysaccharide content. The total phenolic content and total polysaccharide content results of the combinations depended on the respective ratios of the individual extracts. S. corbularia alone and combination 3 (which contained 75% S. corbularia : 25% P. linteus ) demonstrated the greatest radical scavenging activity, followed by combination 1 (50% S. corbularia : 50% P. linteus ), combination 2 (25% S. corbularia : 75% P. linteus ) and P. linteus . The toxicity results of the extract samples on the cancer cells corresponded with their antioxidant activity. In particular, certain combinations demonstrated clearer inhibitory effects on cell proliferation against three types of breast cancer cells compared with those exerted by the two individual extracts. However, induction of apoptosis was limited, with the degree of apoptosis observed to be #x003C;5%. These findings suggested that treatment with combinations of these two extracts could confer enhanced antioxidant and antiproliferative effects on breast cancer cells. Therefore, the potential of these two extracts in combination as anticancer agents warrants further investigation.

show abstract

Section: Introductionmentioning

confidence: 99%

In vitro antioxidant and anticancer activities of Smilax corbularia extract combined with Phellinus linteus extract against breast cancer cell lines

Syukriya,

Bankeeree,

Prasongsuk

et al. 2023

Biomed Rep

View full text Add to dashboard Cite

show abstract

“…For example, the lettuces polysaccharides could improve the phagocytosis of the RAW264.7 cells, because NO production was increased from 16 to 28 μmol/L [ 50 ]. It was found that the Phellinus linteus polysaccharides could inhibit the growth of thyroid cancer cells, promote cell apoptosis, and suppress cell migration and invasion [ 51 ]. Additionally, the homo-polysaccharide isolated from the dried Cornus pulp could reduce fasting blood glucose levels in streptozotocin-induced diabetic rats [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

The Barrier-Enhancing Function of Soluble Yam (Dioscorea opposita Thunb.) Polysaccharides in Rat Intestinal Epithelial Cells as Affected by the Covalent Se Conjugation

Wang

Zhao

2022

Nutrients

View full text Add to dashboard Cite

The non-starch yam polysaccharides (YP) are the bioactive substances of edible yam, while Se is an essential nutrient for the human body. Whether a covalent conjugation of Se to YP might cause bioactivity change for the resultant selenylated YP in the intestine is still insufficiently studied, including the critical intestinal barrier function. In this study, two selenylated YP products, namely, YPSe-I and YPSe-II, with corresponding Se contents of 795 and 1480 mg/kg, were obtained by the reaction of YP and Na2SeO3 in the presence of HNO3 and then assessed for their bioactivities to a cell model (i.e., rat intestinal epithelial IEC-6 cells). The results showed that YP, YPSe-I, and YPSe-II at 5–80 μg/mL dosages could promote cell growth with treatment times of 12–24 h. The three samples also could improve barrier integrity via increasing cell monolayer resistance and anti-bacterial activity against E. coli or by reducing paracellular permeability and bacterial translocation. Additionally, the three samples enhanced F-actin distribution and promoted the expression of the three tight junction proteins, namely, zonula occluden-1, occludin, and claudin-1. Meanwhile, the expression levels of ROCK and RhoA, two critical proteins in the ROCK/RhoA singling pathway, were down-regulated by these samples. Collectively, YPSe-I and, especially, YPSe-II were more potent than YP in enhancing the assessed bioactivities. It is thus concluded that this chemical selenylation of YP brought about enhanced activity in the cells to promote barrier integrity, while a higher selenylation extent of the selenylated YP induced much activity enhancement. Collectively, the results highlighted the important role of the non-metal nutrient Se in the modified polysaccharides.

show abstract

Recent advances in the bioactive polysaccharides and other key components from Phellinus spp. and their pharmacological effects: A review

Zhang

Jiang

et al. 2022

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Systematic evaluation of the anti-tumor effect of Phellinus linteus polysaccharide in thyroid carcinoma in vitro

Cited by 7 publications

References 37 publications

In vitro antioxidant and anticancer activities of Smilax corbularia extract combined with Phellinus linteus extract against breast cancer cell lines

In vitro antioxidant and anticancer activities of Smilax corbularia extract combined with Phellinus linteus extract against breast cancer cell lines

The Barrier-Enhancing Function of Soluble Yam (Dioscorea opposita Thunb.) Polysaccharides in Rat Intestinal Epithelial Cells as Affected by the Covalent Se Conjugation

Recent advances in the bioactive polysaccharides and other key components from Phellinus spp. and their pharmacological effects: A review

Contact Info

Product

Resources

About