Distributed and collaborative computer-aided design (CAD) environments include building information modeling (BIM) and geographical information systems (GISs) in civil engineering and architecture, or product data management/ product life cycle management (PDM/PLM) in mechanical engineering. It is essential to keep the data integrity in these computer applications as it contributes to building users' confidence in CAD/BIM/PDM data. Blockchain technology, the core foundation of cryptocurrencies, is increasingly being used for other purposes and could solve the data integrity issue in collaborative CAD environments. However, it has some disadvantages such as the transparency of data and the slowness of storing data in the blockchain due to distributed consensus. Increasing demand by the Industry 4.0, IoT, Smart Cities, and other initiatives could foster the best what blockchain has to offer: data integrity, reliability, and traceability. This chapter explains how blockchain works, how can it be utilized in distributed CAD environments, what are the major challenges for implementation, and how CAD vendors could use it to increase CAD data integrity.