Systematic Lymph Node Dissection May Be Abolished in Patients With Apparent Early-Stage Low-Grade Mucinous and Endometrioid Epithelial Ovarian Cancer

Chen, Jiayu; Yin, Jie; Li, Yan; Gu, Yu; Wang, Wei; Shan, Ying; Wang, Yongxue; Qin, Meng; Cai, Yan; Jin, Ying; Pan, Lingya

doi:10.3389/fonc.2021.705720

Cited by 13 publications

(21 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, there is no significant difference in prognosis between lymph node sampling and dissection. This result differs slightly from other previous studies, which may be due to the limited size and design of the reported studies (10,11,18). Similarly, age and laterality are independent risk factors, and related studies have confirmed these risk factors (18,19).…”

Section: Discussioncontrasting

confidence: 89%

“…Age at diagnosis was classified into three groups, patients under 30 years old, patients between 30 and 50 years old, and patients over 50 years old. Regarding the number of lymph node dissections, all patients were divided into two groups, without lymph node dissection and with lymph node dissection, including lymph node sampling (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) and lymph node dissection ([?] 20), and the study endpoint was OS, survival to time of death from any cause.…”

Section: Study Variablesmentioning

confidence: 99%

“…One study suggests that lymphadenectomy in surgical staging improves disease-free survival and overall survival (8,9). In contrast, some studies report no effect of lymph node dissection on recurrence, disease-free interval, or overall survival in patients with early-stage MOC for whom lymphadenectomy can be discontinued (10)(11)(12). Lymph node dissection has been reported to be closely associated with postoperative complications such as macrovascular injury, excessive bleeding, neurologic involvement, increased operative time, lymphocyte formation, lymphocyte leakage, and leg edema (12).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Outcomes of Lymphadenectomy for Early-Stage Mucinous Ovarian Cancer: A Retrospective Study Based on Surveillance, Epidemiology, and End Results (SEER) Database

Cheng

Zeng

Cui

et al. 2022

Preprint

View full text Add to dashboard Cite

Objective: To evaluate the efficacy of lymphadenectomy for early-stage primary mucinous ovarian cancer (MOC). Design: Retrospective observation study Setting: Surveillance, Epidemiology, and End Results (SEER) database for 2000-2018 Population or sample: The study population comprised 1848 patients with early-stage MOC Methods: MOCs were divided into two groups according to lymphadenectomy. Propensity score matching were performed to correct for deviations. Independent risk factors for overall survival (OS) were determined by multivariate analysis using Cox regression. The role of lymphadenectomy was performed in different populations by stratified analysis applying interaction analysis. OS was calculated by Kaplan-Meier curves and compared by log-rank test. Main outcome measures: Overall survival Results: In the study, almost 65.8% (n = 1214/1848) experienced lymphadenectomy. Lymphadenectomy (HR = 0.692, 95% CI = 0.516-0.927, P = 0.009), age at diagnosis (HR = 3.028, 95% CI = 1.477-6.208, P = 0.002), and laterality (HR = 2.013, 95% CI = 1.145-3.54, P = 0.015) were found to be associated with OS. The role of lymphadenectomy varied by age group and tumor laterality, and the 5-year survival rates of patients with bilateral tumors who had experienced lymphadenectomy with sampling and dissection, or for MOC over age 50 and were higher than that of patients who did not undergo lymphadenectomy. Conclusion: Lymphadenectomy with sampling and dissection has little impact on OS in patients with early MOC. Lymph node therapy can be discontinued in patients younger than 50 years, and lymph node sampling is recommended for patients older than 50 years or with bilateral tumors.

show abstract

Section: Discussioncontrasting

confidence: 89%

Section: Study Variablesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Outcomes of Lymphadenectomy for Early-Stage Mucinous Ovarian Cancer: A Retrospective Study Based on Surveillance, Epidemiology, and End Results (SEER) Database

Cheng

Zeng

Cui

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“… 12 For RWS, Chen et al found that for patients with early-stage MOC, lymphadenectomy had no significant prognostic benefit. 13 For patients with advanced stage EOC, however, Tatsuyuki Chiyoda et al revealed that the lymphadenectomy was associated with improved OS for patients with advanced stage EOC. 14 This indicated that more studies are needed to explore the effect of lymphadenectomy on the prognosis of patients with MOC, especially advanced-stage patients.…”

Section: Introductionmentioning

confidence: 99%

A Nomogram Based on SEER Database for Predicting Prognosis in Patients with Mucinous Ovarian Cancer: A Real-World Study

Zhang¹,

Feng²,

Yu³

et al. 2022

IJWH

View full text Add to dashboard Cite

Mucinous ovarian cancer (MOC) is a rare histological type of EOC. In order to guide the clinical diagnosis and management of MOC patients, we constructed and verified a nomogram for the estimation of overall survival in patients with MOC. Patients and Methods: We collected 494 patients with MOC diagnosed from 2010 to 2015 in SEER database, and the following main inclusion criteria were used: (1) patients whose MOC was confirmed by pathology; (2) patients without a history of primary other cancer. Subsequently, we performed randomized grouping (6:4) and Cox hazard regression analysis in the training group. Subsequently, the nomogram was established. A variety of indicators were used to validate the prognosis value of nomogram, including the C-index, area under the receiver operating characteristic curve, calibration curve, and decision curve analysis (DCA). Moreover, Kaplan-Meier analysis was used to compare the survival results among different risk subgroups. Results: Cox hazard regression analysis revealed that age, grade, FIGO stage and log odds of positive lymph nodes stage were independent risk factors for patients with MOC. In the training group, the C-index of the nomogram was 0.827 (95% CI: 0.791-0.863) and the areas under the curve (AUC) predicting the 1-, 3-and 5-year survival rate were 0.853 (95% CI: 0.791-0.915), 0.886 (95% CI: 0.852-0.920) and 0.815 (95% CI: 0.766-0.864), respectively. The calibration curve revealed that the nomogram of the 1-, 3-and 5-year survival rate was consistent with the actual fact. Patients with high risk had a poorer prognosis than those with low risk (P < 0.001). DCA revealed that the nomogram had the best clinical value than other classical prognostic markers. Similarly, nomogram had excellent prognostic ability in the testing group. Conclusion:The nomogram was constructed to predict overall survival in patients with MOC, which had the significance for clinical evaluation.

show abstract

“…The total number of patients included in the eight studies was 2964, but only 277 patients had early-stage low-grade serous tumors and were considered for the analysis. Seven studies were retrospective series13–19 and one study was a population-based study 20. The accrual time was from 1975 up to 2018.…”

Section: Resultsmentioning

confidence: 99%

Incidence of lymph node metastasis in early-stage low-grade serous ovarian cancer: a systematic review

Viveros‐Carreño

Rodriguez

Pareja

2022

International Journal of Gynecological Cancer

View full text Add to dashboard Cite

ObjectiveThe objective of this systematic review was to assess the incidence of lymph node metastasis in patients with clinically presumed early-stage low-grade serous ovarian cancer that underwent primary surgical treatment.MethodsThis study was registered in PROSPERO (CRD42022308923). A systematic literature review was conducted following the Meta-analyses Of Observational Studies in Epidemiology (MOOSE) checklist. PubMed/MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Ovid, and Scopus databases were searched since inception and up to March 2022. The inclusion criteria were: pathological confirmation of low-grade serous ovarian cancer (clinically presumed FIGO 2014 stages I-IIA at time of surgery) that underwent primary surgical treatment, including pelvic and/or para-aortic lymph node dissection.ResultsThe search identified 3763 articles; 59 were considered potentially eligible after removing duplicates, and eight studies finally met the selection criteria. In total, 35 of 277 (12.6%) patients had lymph node metastasis, and only four studies reported upstaging due to lymph node metastasis in 16 of 153 (10.5%) patients. None of the eight studies included reported the rate of complications or complications specifically for the subgroup of patients with early-stage low-grade tumors.ConclusionIn patients with early-stage low-grade serous ovarian cancer, lymph node assessment should be discussed when counseling for primary surgical staging.

show abstract

Systematic Lymph Node Dissection May Be Abolished in Patients With Apparent Early-Stage Low-Grade Mucinous and Endometrioid Epithelial Ovarian Cancer

Cited by 13 publications

References 32 publications

Outcomes of Lymphadenectomy for Early-Stage Mucinous Ovarian Cancer: A Retrospective Study Based on Surveillance, Epidemiology, and End Results (SEER) Database

Outcomes of Lymphadenectomy for Early-Stage Mucinous Ovarian Cancer: A Retrospective Study Based on Surveillance, Epidemiology, and End Results (SEER) Database

A Nomogram Based on SEER Database for Predicting Prognosis in Patients with Mucinous Ovarian Cancer: A Real-World Study

Incidence of lymph node metastasis in early-stage low-grade serous ovarian cancer: a systematic review

Contact Info

Product

Resources

About