Systematic Molecular Phenotyping: A Path Toward Precision Emergency Medicine?

Monte, Andrew A.; Kabrhel, Christopher; Puskarich, Michael A.; Heitsch, Laura; Tsalik, Ephraim L.; Shapiro, Nathan I.

doi:10.1111/acem.13027

Cited by 17 publications

(8 citation statements)

References 36 publications

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“…Precision medicine aims to customize treatment strategies based on individual patient variability . Population‐level data allow researchers to characterize the phenotypic differences within conditions and specifically identify patients who do not respond to standards of care . Omics techniques (genomics, metabolomics, proteomics, etc.)…”

mentioning

confidence: 99%

The Emergency Medicine Specimen Bank: An Innovative Approach To Biobanking In Acute Care

Saben

Shelton

Hopkinson

et al. 2018

Academic Emergency Medicine

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The Emergency Medicine Specimen Bank (EMSB) was developed to facilitate precision medicine in acute care. The EMSB is a biorepository of clinical health data and biospecimens collected from all adult English-or Spanish-speaking individuals who are able and willing to provide consent and are treated at the UCHealth-University of Colorado Hospital Emergency Department. The EMSB is the first acute care biobank that seeks to enroll all patients, with all conditions who present to the ED. Acute care biobanking presents many challenges investigator-initiated research. AAM owns stock in Illumina, the company that makes the MEGA chip genotyping platform utilized at the University of Colorado. There were no financial inducements or services donated by Illumina for this work. Illumina had no role in designing this project, had no access to data, and had no involvement in the preparation of this manuscript. Author Contributions: JLS-protocol concept, design, and implementation; regulatory management and daily oversight; training personnel on protocol; and drafting of the manuscript. SKS-protocol concept and design, training personnel on protocol, and daily project management. AJHprotocol concept and design, training personnel on protocol, and daily project management. BJS-protocol concept and design, training personnel on protocol, and daily project management. EBM-protocol concept and design, training personnel on protocol, and daily project management; MWel and MWes-daily project implementation; RZ-protocol design and implementation and critical revision of the manuscript for important intellectual content. AAG-protocol concept, design, and implementation and critical revision of the manuscript for important intellectual content; KB-protocol design and implementation and critical revision of the manuscript for important intellectual content. JO-protocol design and implementation. MC-protocol design and implementation. MD-critical revision of the manuscript for important intellectual content. AL-protocol concept and design, regulatory oversight, and critical revision of the manuscript for important intellectual content. JH-protocol concept and design, regulatory oversight, and critical revision of the manuscript for important intellectual content. LBR-protocol design and implementation and critical revision of the manuscript for important intellectual content. ERR-daily project management. MT-protocol concept and design and critical revision of the manuscript for important intellectual content. MJA-critical revision of the manuscript for important intellectual content. KCprotocol concept and design and critical revision of the manuscript for important intellectual content. SJW-protocol concept and design and critical revision of the manuscript for important intellectual content. KCB-protocol concept and design, critical revision of the manuscript for important intellectual content, and acquisition of funding. AAM-protocol concept and design, critical revision of the manuscript for important intellectual content, and acquis...

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mentioning

confidence: 99%

The Emergency Medicine Specimen Bank: An Innovative Approach To Biobanking In Acute Care

Saben

Shelton

Hopkinson

et al. 2018

Academic Emergency Medicine

Self Cite

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“…The most common form of this is pharmacogenomics. Any of these approaches can produce thousands of data points on a patient from a single biological specimen, such as a peripheral blood sample [ 45 ]. Accordingly, ML and AI approaches can be an ideal method for determining which of these data points are associated with disease states of interest.…”

Section: Reviewmentioning

confidence: 99%

Machine Learning and Precision Medicine in Emergency Medicine: The Basics

Lee

Lam

Rocha

et al. 2021

Cureus

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As machine learning (ML) and precision medicine become more readily available and used in practice, emergency physicians must understand the potential advantages and limitations of the technology. This narrative review focuses on the key components of machine learning, artificial intelligence, and precision medicine in emergency medicine (EM). Based on the content expertise, we identified articles from EM literature. The authors provided a narrative summary of each piece of literature. Next, the authors provided an introduction of the concepts of ML, artificial intelligence as an extension of ML, and precision medicine. This was followed by concrete examples of their applications in practice and research. Subsequently, we shared our thoughts on how to consume the existing research in these subjects and conduct high-quality research for academic emergency medicine. We foresee that the EM community will continue to adapt machine learning, artificial intelligence, and precision medicine in research and practice. We described several key components using our expertise.

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“…A harmonization of technical and bioinformatic approaches will continue to occupy future generations studying IS pathogenesis based on human studies. The aim is to decipher and interpret clinical results to ascertain the significance of miRNAs that are beneficial for human therapeutic applications [ 21 , 179 , 180 , 181 ].…”

Section: Mirna Profiling and Ischemic Strokementioning

confidence: 99%

Can miRNAs Be Considered as Diagnostic and Therapeutic Molecules in Ischemic Stroke Pathogenesis?—Current Status

Bulygin

Beeraka

Saitgareeva

et al. 2020

IJMS

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Ischemic stroke is one of the leading causes of death worldwide. Clinical manifestations of stroke are long-lasting and causing economic burden on the patients and society. Current therapeutic modalities to treat ischemic stroke (IS) are unsatisfactory due to the intricate pathophysiology and poor functional recovery of brain cellular compartment. MicroRNAs (miRNA) are endogenously expressed small non-coding RNA molecules, which can act as translation inhibitors and play a pivotal role in the pathophysiology associated with IS. Moreover, miRNAs may be used as potential diagnostic and therapeutic tools in clinical practice; yet, the complete role of miRNAs is enigmatic during IS. In this review, we explored the role of miRNAs in the regulation of stroke risk factors viz., arterial hypertension, metabolic disorders, and atherosclerosis. Furthermore, the role of miRNAs were reviewed during IS pathogenesis accompanied by excitotoxicity, oxidative stress, inflammation, apoptosis, angiogenesis, neurogenesis, and Alzheimer’s disease. The functional role of miRNAs is a double-edged sword effect in cerebral ischemia as they could modulate pathological mechanisms associated with risk factors of IS. miRNAs pertaining to IS pathogenesis could be potential biomarkers for stroke; they could help researchers to identify a particular stroke type and enable medical professionals to evaluate the severity of brain injury. Thus, ascertaining the role of miRNAs may be useful in deciphering their diagnostic role consequently it is plausible to envisage a suitable therapeutic modality against IS.

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Systematic Molecular Phenotyping: A Path Toward Precision Emergency Medicine?

Cited by 17 publications

References 36 publications

The Emergency Medicine Specimen Bank: An Innovative Approach To Biobanking In Acute Care

The Emergency Medicine Specimen Bank: An Innovative Approach To Biobanking In Acute Care

Machine Learning and Precision Medicine in Emergency Medicine: The Basics

Can miRNAs Be Considered as Diagnostic and Therapeutic Molecules in Ischemic Stroke Pathogenesis?—Current Status

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