Systematic Review and Meta‐Analysis: <i>Helicobacter pylori</i> Eradication Therapy After Simple Closure of Perforated Duodenal Ulcer

Tomtitchong, Prakitpunthu; Siribumrungwong, Boonying; Vilaichone, Ratha-Korn; Kasetsuwan, Petch; Matsukura, Norio; Chaiyakunapruk, Nathorn

doi:10.1111/j.1523-5378.2011.00928.x

Cited by 23 publications

(18 citation statements)

References 17 publications

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“…Comment: Almost all reports are in concordance for eradication after gastric preserving surgery [152]. There is no agreement about eradication after distal gastrectomy.…”

Section: Surgical Treatmentmentioning

confidence: 86%

Evidence-based clinical practice guidelines for peptic ulcer disease 2015

et al. 2016

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The Japanese Society of Gastroenterology (JSGE) revised the evidence-based clinical practice guidelines for peptic ulcer disease in 2014 and has created an English version. The revised guidelines consist of seven items: bleeding gastric and duodenal ulcers, Helicobacter pylori (H. pylori) eradication therapy, non-eradication therapy, drug-induced ulcer, non-H. pylori, non-nonsteroidal anti-inflammatory drug (NSAID) ulcer, surgical treatment, and conservative therapy for perforation and stenosis. Ninety clinical questions (CQs) were developed, and a literature search was performed for the CQs using the Medline, Cochrane, and Igaku Chuo Zasshi databases between 1983 and June 2012. The guideline was developed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Therapy is initially provided for ulcer complications. Perforation or stenosis is treated with surgery or conservatively. Ulcer bleeding is first treated by endoscopic hemostasis. If it fails, surgery or interventional radiology is chosen. Second, medical therapy is provided. In cases of NSAID-related ulcers, use of NSAIDs is stopped, and anti-ulcer therapy is provided. If NSAID use must continue, the ulcer is treated with a proton pump inhibitor (PPI) or prostaglandin analog. In cases with no NSAID use, H. pylori-positive patients receive eradication and anti-ulcer therapy. If first-line eradication therapy fails, second-line therapy is given. In cases of non-H. pylori, non-NSAID ulcers or H. pyloripositive patients with no indication for eradication therapy, non-eradication therapy is provided. The first choice is PPI therapy, and the second choice is histamine 2-receptor antagonist therapy. After initial therapy, maintenance therapy is provided to prevent ulcer relapse.

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“…Comment: Almost all reports are in concordance for eradication after gastric preserving surgery [152]. There is no agreement about eradication after distal gastrectomy.…”

Section: Surgical Treatmentmentioning

confidence: 86%

Evidence-based clinical practice guidelines for peptic ulcer disease 2015

et al. 2016

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“…Indeed, evidence from a systematic review and meta-analysis of this approach has suggested empirical treatment with H. pylori eradication therapy is superior to antisecretory treatment alone 10. Other risk factors such as hypersecretory states should also be sought and treated.…”

Section: Discussionmentioning

confidence: 99%

Atypical presentation of perforated peptic ulcer disease in a 12-year-old boy

Mbarushimana¹,

Morris‐Stiff

Thomas

2014

BMJ Case Reports

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A 12-year-old boy was referred to the surgical unit with 4 h history of severe lower abdominal pain and bilious vomiting. No other symptoms were reported and there was no significant medical or family history. Examination revealed tenderness in the lower abdomen, in particular the left iliac fossa. His white cell count was elevated at 19.6×10(9)/L, with a predominant neutrophilia of 15.8×10(9)/L and a C reactive protein of <0.3 mg/L. An abdominal X-ray revealed intraperitoneal gas and a chest X-ray identified free air under both hemidiaphragms. Subsequent diagnostic laparoscopy identified a perforated duodenal ulcer that was repaired by means of an omental patch. The case illustrates that although uncommon, alternate diagnoses must be borne in mind in children presenting with lower abdominal pain and diagnostic laparoscopy is a useful tool in children with visceral perforation as it avoids treatment delays and exposure to excess radiation.

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“…Laparoscopic simple closure operations for peptic ulcer perforation are now widely accepted worldwide, favoring the less-invasive simple closure technique with postoperative H. pylori eradication. A systematic review and meta-analysis of patients with duodenal ulcer perforation compared the simple closure method plus postoperative H. pylori eradication therapy to simple closure and antisecretory noneradication therapy, showing that H. pylori eradication after simple closure of duodenal ulcer perforation provided better results than the operation plus antisecretory noneradication therapy for preventing ulcer recurrence [8]. The Maastricht III and the newest Maastricht IV Consensus Report guidelines recommended bacterial eradication in infected patients presenting with ulcer complications [9,10].…”

Section: Peptic Ulcer Diseasementioning

confidence: 99%

Helicobacter pylori and Nonmalignant Diseases

et al. 2012

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The incidence of peptic ulcer disease has declined over the last few decades, particularly in Western populations, most likely as a result of the decrease in Helicobacter pylori infection and the widespread use of proton-pump inhibitors (PPI) in patients with dyspepsia. The hospital admission rate for uncomplicated duodenal and gastric ulcers has significantly decreased worldwide. In contrast, admissions for complicated ulcer disease, such as bleeding peptic ulcers and perforation, remained relatively stable. Prophylactic H. pylori eradication was found to be associated with a reduced risk of both gastric and duodenal ulcers and their complications, including bleeding in chronic users of nonsteroidal anti-inflammatory drugs. The recent Helicobacter Eradication Relief of Dyspeptic Symptoms trial presented important data relating to symptoms and quality of life of H. pylori-positive patients with functional dyspepsia (FD) and also demonstrated significant benefits from eradication compared with the control group. The new Asian consensus report on FD recommended that dyspepsia accompanied by H. pylori infection should be considered a separate disease entity from FD and that H. pylori infection should be eradicated before diagnosing FD. The association of H. pylori with gastroesophageal reflux disease (GERD) is still controversial. Treatment for H. pylori does not seem to increase GERD symptoms or reflux esophagitis. However, documented eradication of H. pylori appears to significantly improve GERD symptoms. Additional long-term intervention studies are needed to provide more information on which to base clinical decisions.

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Systematic Review and Meta‐Analysis: Helicobacter pylori Eradication Therapy After Simple Closure of Perforated Duodenal Ulcer

Cited by 23 publications

References 17 publications

Evidence-based clinical practice guidelines for peptic ulcer disease 2015

Evidence-based clinical practice guidelines for peptic ulcer disease 2015

Atypical presentation of perforated peptic ulcer disease in a 12-year-old boy

Helicobacter pylori and Nonmalignant Diseases

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