Systematic review and meta-analysis of the adverse health effects of ambient PM2.5 and PM10 pollution in the Chinese population

Lü, Feng; Xu, Dongqun; Cheng, Yibin; Dong, Shoukun; Guo, Chao; Jiang, Xue; Zheng, Xiaoying

doi:10.1016/j.envres.2014.06.029

Cited by 607 publications

(318 citation statements)

References 57 publications

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“…Epidemiological studies have provided convincing evidence that long-term or short-term PM 2.5 exposure is associated with cardiovascular disease (CVD), including arrhythmia, atherosclerosis, myocardial ischemia and even heart failure (HF) exacerbation (Brook et al, 2010;Shah et al, 2013;Su et al, 2015). Lu et al (2015) found that a 10 μg/m 3 increase in PM 2.5 relates to a 0.63% increase due to CVD mortality. Another study also reported that an increase of 10 μg/m 3 in 2-day moving average concentration of PM 2.5 corresponds to 1.22% increase of CVD mortality (Yang et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

The involvement of Nox4 in fine particulate matter exposure-induced cardiac injury in mice

Wu¹,

Zhang²

2018

J. Toxicol. Sci.

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-Epidemiological studies have confirmed that ambient fine particulate matter (PM 2.5 ) exposure is associated with cardiovascular disease (CVD). However, the underlying mechanisms in PM 2.5 exposure-induced heart injury are largely unknown. It has been acknowledged that NADPH oxidase (Nox) 4 plays a critical role in CVD development. To investigate the acute effects of PM 2.5 on the mouse heart and the role of Nox4 in PM 2.5 exposure-induced cardiac injury, C57BL/6J mice were instilled with saline or 1.5, 3.0, 6.0 mg/kg BW PM 2.5 suspension for two weeks (five days per week). The levels of malondialdehyde (MDA), super oxide dismutase (SOD), inducible nitric oxide synthase (iNOS), tumor necrosis factor-α (TNF-α) and interleukin (IL)-1β in heart supernatants were determined using related kits. The expression of Nox4, p67 phox , p47 phox and p22 phox in heart tissue was evaluated by immunofluorescence staining or Western blotting, respectively. Protein levels of p53, Bax, Bcl-2 and Caspase-3 in the heart were examined using immunohistochemical staining and Western blotting. TUNEL assay was used to measure myocardial apoptosis. PM 2.5 exposure leads to obvious cardiac injury. PM 2.5 exposure increases MDA level and iNOS activity, and decreases activity of SOD in heart supernatants of mice. High levels of TNF-α and IL-1β in heart supernatants of mice with PM 2.5 instillation were determined. Nox4 and Noxassociated subunits such as p67 phox , p47 phox and p22 phox expression levels were increased in heart tissue of mice after PM 2.5 exposure. Additionally, PM 2.5 exposure causes myocardial apoptosis in the mouse heart. This study suggested that Nox4 is involved in PM 2.5 exposure-induced cardiac injury in mice.

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Section: Introductionmentioning

confidence: 99%

The involvement of Nox4 in fine particulate matter exposure-induced cardiac injury in mice

Wu¹,

Zhang²

2018

J. Toxicol. Sci.

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“…One of the major air pollutants is PM 2.5 (fine particles with aerodynamic diameters less than or equal to 2.5 µm), which remains a nationwide problem despite considerable efforts for its removal (Lu et al, 2015). Accounting for a large fraction of PM 2.5 mass, sulfate (SO 4 2-), nitrate (NO 3 -), and ammonium (NH 4 + ) are the main secondary inorganic ions in fine particulate matters (He et al, 2001;Wang et al, 2005;Li et al, 2013;Zhang et al, 2013a;.…”

Section: Introductionmentioning

confidence: 99%

Variation of Urban Atmospheric Ammonia Pollution and its Relation with PM2.5 Chemical Property in Winter of Beijing, China

Zhao

Wang

Tan

et al. 2016

Aerosol Air Qual. Res.

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To understand the air pollution problem in megacities such as Beijing, field measurement investigating the variation of NH 3 and its association with PM 2.5 chemical property was conducted from 25 November to 24 December 2013. The results indicated that the daily concentration of wintertime NH 3 tended to be high on the days with relatively high temperatures and low wind speeds. Affected by the synoptic condition, NH 3 concentration showed a bimodal diurnal variation pattern, which tended to peak at around 09:00 and 22:00 of the day. As the sole precursor for NH 4 + , NH 3 exerted a significant impact on the ion chemistry of PM 2.5 through enhancing the nighttime NH 4 Cl formation and promoting both homogeneous and heterogeneous formation of NO 3 -. During heavy pollution episodes with PM 2.5 concentrations over 200 µg m -3 , the NH 3 levels and NH 4 + /NH 3 ratios grew simultaneously with the increase of PM 2.5 levels, indicating that NH 3 is one of the key reasons for heavy pollution events. Revealed by the features of measured ionic species in PM 2.5 , in conjunction with the acidity analysis using thermodynamic model, our results suggested that NH 3 was frequently sufficient in wintertime atmosphere of urban Beijing and the fine particulates were neutralized nearly fully by NH 3 .

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“…In particular, these particles contain toxic metals and exhibit higher possibilities of causing cancer (Dockery et al, 1993). Over the past decade, special attention has been paid to investigate the concentrations, chemical characteristics, sources, and adverse health effects of PM pollution in megacities of China (Chen et al, 2013;Lu et al, 2015;Niu et al, 2015;Hu et al, 2016;Lyu et al, 2016;Ma et al, 2016;Madaniyazi et al, 2016;Chen et al, 2017;Peng et al, 2017), and high concentrations of toxic metals in PM 10 have been reported in many cities (Kan et al, 2012;Lu et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Characteristics, Sources, and Health Risk Assessment of Trace Elements in PM10 at an Urban Site in Chengdu, Southwest China

Cheng

Huang

Shipeng

et al. 2018

Aerosol Air Qual. Res.

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To investigate trace element pollution of PM 10 in urban Chengdu, a Southwest megacity of China, as well as to assess the human health risks caused by exposure to PM 10 , we analyzed ambient PM 10 samples collected at an urban site in Chengdu from November, 2014 to October, 2015. The annual mean concentration of PM 10 in the sampling period was 173.6 ± 77.9 µg m -3 , which is 2.5 times higher than the national recommended standard of 70 µg m -3 . The mean metals content in PM 10 was in the following order:The concentration of As in PM 10 was observed to be 2.9 times higher than the secondary level recommended by the China National Ambient Air Quality Standard (GB3095-2012), whereas the concentrations of other metals were within the limit. Enrichment factor analysis indicated that As, Pb, Zn, Cu, Cd, and Sb mainly originated from anthropogenic sources. Five factors were identified by positive matric factorization (PMF) model. The sources identified were soil dust (48.4%), road dust (19.4%), fossil fuel combustion (14.9%), electroplating industry (13.8%), and metallurgy industry (3.5%). Particle morphology and chemical composition analysis revealed six major particle types, namely aluminosilicate, sulfur-containing, carbon-containing, chlorine-containing, biomass burning, and metal particles. The results of the health risk assessment indicated that Cr can be carcinogenic to both children and adults, and other trace elements were determined to be below the legislation threshold (Environmental Protection Agency limit values), except for As, which was observed to be above the threshold.

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Systematic review and meta-analysis of the adverse health effects of ambient PM2.5 and PM10 pollution in the Chinese population

Cited by 607 publications

References 57 publications

The involvement of Nox4 in fine particulate matter exposure-induced cardiac injury in mice

The involvement of Nox4 in fine particulate matter exposure-induced cardiac injury in mice

Variation of Urban Atmospheric Ammonia Pollution and its Relation with PM2.5 Chemical Property in Winter of Beijing, China

Characteristics, Sources, and Health Risk Assessment of Trace Elements in PM10 at an Urban Site in Chengdu, Southwest China

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