Systematic review and meta-analysis of the effectiveness of antibiotic prophylaxis in prevention of wound infection after mesh repair of abdominal wall hernia

Aufenacker, Theo; Koelemay, M.J.W.; Gouma, Dirk J.; Simons, M. P.

doi:10.1002/bjs.5186

Cited by 98 publications

(59 citation statements)

References 28 publications

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“…Also the percentage of wound infection in the placebo group has a large variation between 0 and 15 %; to correct for this broad baseline percentage of wound infections we propose to enlarge the confidence interval from 95 to 99 % for the overall analysis. The same methods were followed as described in one of the earlier published meta-analyses [48]. The results of the analysis of data from all 12 RCTs demonstrate an incidence of wound infection of 82/1,862 (4.4 %) patients in the placebo group and 48/1,831 (2.6 %) after antibiotic prophylaxis.…”

Section: Antibiotic Prophylaxismentioning

confidence: 99%

Update with level 1 studies of the European Hernia Society guidelines on the treatment of inguinal hernia in adult patients

Miserez

Peeters

Aufenacker

et al. 2014

Hernia

366

226

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Purpose: In 2009, the European Hernia Society published the EHS Guidelines for the Treatment of Inguinal Hernia in Adult Patients. The Guidelines contain recommendations for the treatment of inguinal hernia from diagnosis till aftercare. The guidelines expired January 1, 2012. To keep them updated, a revision of the guidelines was planned including new level 1 evidence. Methods: The original Oxford Centre for Evidence-Based Medicine ranking was used. All relevant level 1A and level 1B literature from May 2008 to June 2010 was searched (Medline and Cochrane) by the Working Group members. All chapters were attributed to the two responsible authors in the initial guidelines document. One new chapter on fixation techniques was added. The quality was assessed by the Working Group members during a 2-day meeting and the data were analysed, especially with respect to any change in the level and/or text of any of the conclusions or recommendations of the initial guidelines. In the end, all relevant references published until January 1, 2013 were included. The final text was approved by all Working Group members. Results: For the following topics, the conclusions and/or recommendations have been changed: indications for treatment, treatment of inguinal hernia, day surgery, antibiotic prophylaxis, training, postoperative pain control and chronic pain. The addendum contains all current level 1 conclusions, Grade A recommendations and new Grade B recommendations based on new level 1 evidence (with the changes in bold). Conclusions: Despite the fact that the Working Group responsible for it tried to represent most kinds of surgeons treating inguinal hernias, such general guidelines inevitably must be fitted to the daily practice of every individual surgeon treating his/her patients. There is no doubt that the future of guideline implementation will strongly depend on the development of easy to use decision support algorithms tailored to the individual patient and on evaluating the effect of guideline implementation on surgical outcome. At the 35th International Congress of the EHS in Gdansk, Poland (May 12-15, 2013), it was decided that the EHS, IEHS and EAES will collaborate from now on with the final goal to publish new joint guidelines, most likely in 2015

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Section: Antibiotic Prophylaxismentioning

confidence: 99%

Update with level 1 studies of the European Hernia Society guidelines on the treatment of inguinal hernia in adult patients

Miserez

Peeters

Aufenacker

et al. 2014

Hernia

366

226

View full text Add to dashboard Cite

show abstract

“…1), since they are of a possibly lower quality because of their methods of randomisation but including or excluding them in the analysis does not influence the overall conclusions. Since a formal presentation of the data used together with a systematic review is beyond the scope of this commentary, I want to point out that the same methods were follow as described in one of the earlier published meta-analysis [8].…”

Section: The Current Evidence Based Verdict On Antibiotic Prophylaxismentioning

confidence: 99%

The danger of performing meta-analysis and the impact of guidelines

Aufenacker

2013

Hernia

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“…A Cochrane meta-analysis on this topic in 2004 concluded that antibiotic prophylaxis in mesh repair of inguinal hernias can neither be recommended nor discarded. 5 Hence, we designed this study to define the role of prophylactic antibiotics in prevention of wound infection in mesh inguinal hernia repair and to analyse the risk factors for wound infection in mesh inguinal hernia repair.…”

Section: Introductionmentioning

confidence: 99%

Role of Antibiotic Prophylaxis in Elective Mesh Inguinal Hernioplasty

Santhi¹,

Robert²,

Rengasamy³

2018

jebmh

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Systematic review and meta-analysis of the effectiveness of antibiotic prophylaxis in prevention of wound infection after mesh repair of abdominal wall hernia

Abstract: Antibiotic prophylaxis did not prevent the occurrence of wound infection after groin hernia surgery. More trials are needed for complete evidence in other areas of abdominal wall hernia.

Cited by 98 publications

References 28 publications

Update with level 1 studies of the European Hernia Society guidelines on the treatment of inguinal hernia in adult patients

Update with level 1 studies of the European Hernia Society guidelines on the treatment of inguinal hernia in adult patients

The danger of performing meta-analysis and the impact of guidelines

Role of Antibiotic Prophylaxis in Elective Mesh Inguinal Hernioplasty

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