In this meta-analysis of 12 studies smokers had a significantly increased risk of schizophrenia compared to non-smokers. Exposure to prenatal tobacco smoke also increased the risk of schizophrenia by 29% compared to those with no exposure to prenatal tobacco smoke. Our findings suggest that smoking, and prenatal tobacco smoke exposure, may be independent risk factors for schizophrenia. These results may have important public health implications for decreasing the incidence of schizophrenia. The possibility of a causal link between smoking and schizophrenia warrants further investigation.