Systematic review and meta-analysis on the relationship between prenatal stress and metabolic syndrome intermediate phenotypes

Burgueño, Adriana Laura; Juárez, Yamila Raquel; Genaro, Ana Marı́a; Tellechea, Mariana Lorena

doi:10.1038/s41366-019-0423-z

Cited by 23 publications

(11 citation statements)

References 68 publications

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“…We have previously performed a meta-analysis in rodents showing that birth weight is significantly decreased in prenatally stressed animals. 22 At weaning, PS-offspring of both sexes showed increased body weight in comparison to unstressed controls, supporting recent findings indicating that prenatal environment may influence the likelihood of developing overweight and obesity. 49 Restraint stress would modify maternal behavior contributing to the long-term effects observed in offspring.…”

Section: Discussionsupporting

confidence: 80%

“…A recent meta-analysis conducted by our group showed that, in humans, PS was associated with increased body mass index in exposed offspring. 22 It has been proposed that when the postnatal environment matches the prenatal one, adaptations of the phenotype of the offspring are beneficial; however, when both environments do not match, these adaptations may lead to the development of different pathologies. 23 In this regard, in a recent meta-analysis of rodent studies, we found that birth weight was decreased in offspring exposed to PS, but then in the absence of a challenging environment, catch-up growth is prevented.…”

Section: Introductionmentioning

confidence: 99%

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Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice

Juárez

Quiroga

Prochnik

et al. 2020

J Dev Orig Health Dis

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Prenatal insults during fetal development result in increased likelihood of developing chronic disease. Obesity, the biggest risk factor for the development of metabolic disease, is affected by several genetic and environmental factors. High-fat diet (HFD) consumption is usually linked with the development of obesity. The main goal of this study was to analyze the impact of the exposure to a HFD in prenatally stressed animals. For this purpose, we subjected pregnant BALB/c mice to restraint stress for 2 h a day between gestational day (GD) 14 and GD 21. Prenatally stressed and control offspring of both sexes were postnatally exposed to a HFD for 24 weeks. We found that prenatal stress (PS) per se produced disturbances in males such as increased total blood cholesterol and triglycerides, with a decrease in mRNA expression of sirtuin-1. When these animals were fed a HFD, we observed a rise in glucose and insulin levels and an increase in visceral adipose tissue gene expression of leptin, resistin, and interleukin-1 beta. Although females proved to be more resilient to PS consequences, when they were fed a HFD, they showed significant metabolic impairment. In addition to the changes observed in males, females also presented an increase in body weight and adiposity and a rise in cholesterol levels.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice

Juárez

Quiroga

Prochnik

et al. 2020

J Dev Orig Health Dis

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“…actions, promoting depression, metabolic syndrome, type 2 diabetes, and heart disease (Mastorci et al, 2009;Anisman et al, 2018;Burgueño et al, 2020). By the same token, some behavioral coping strategies (e.g., avoidant coping) might be effective in the short term but could potentially undermine the adoption of strategies (e.g., obtaining help) that are needed to contend effectively with the stressor in the longer term.…”

Section: Resiliencementioning

confidence: 99%

Resilience: Safety in the Aftermath of Traumatic Stressor Experiences

Matheson

Asokumar

Anisman

2020

Front. Behav. Neurosci.

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The relationship between adverse experiences and the emergence of pathology has often focused on characteristics of the stressor or of the individual (stressor appraisals, coping strategies). These features are thought to influence multiple biological processes that favor the development of mental and physical illnesses. Less often has attention focused on the aftermath of traumatic experiences, and the importance of safety and reassurance that is necessary for longer-term well-being. In some cases (e.g., post-traumatic stress disorder) this may be reflected by a failure of fear extinction, whereas in other instances (e.g., historical trauma), the uncertainty about the future might foster continued anxiety. In essence, the question becomes one of how individuals attain feelings of safety when it is fully understood that the world is not necessarily a safe place, uncertainties abound, and feelings of agency are often illusory. We consider how individuals acquire resilience in the aftermath of traumatic and chronic stressors. In this respect, we review characteristics of stressors that may trigger particular biological and behavioral coping responses, as well as factors that undermine their efficacy. To this end, we explore stressor dynamics and social processes that foster resilience in response to specific traumatic, chronic, and uncontrollable stressor contexts (intimate partner abuse; refugee migration; collective historical trauma). We point to resilience factors that may comprise neurobiological changes, such as those related to various stressor-provoked hormones, neurotrophins, inflammatory immune, microbial, and epigenetic processes. These behavioral and biological stress responses may influence, and be influenced by, feelings of safety that come about through relationships with others, spiritual and place-based connections.

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“…Littleton et al (2010) meta-analysis evaluating the relationship between psychosocial stress in pregnancy and negative perinatal outcomes found that MS affects both neonatal weight and the risk for LBW (Littleton et al, 2010). MS during intrauterine life has also been shown to affect a range of long-term outcomes (Burgueño et al, 2019). A study has found evidence to suggest that exposure to stressful conditions during preconception and the prenatal period may increase the risk for developing Type 2 Diabetes Mellitus in childhood and young adulthood.…”

Section: Translational Potentialmentioning

confidence: 99%

Prenatal stress and later metabolic consequences: Systematic review and meta-analysis in rodents

Burgueño

Juárez

Genaro

et al. 2020

Psychoneuroendocrinology

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Background: Numerous rodent studies have evaluated the effects of maternal stress (MS) on later in life susceptibility to Metabolic Syndrome (MetS) intermediate phenotypes with varying results. The aim of this study was to quantitatively synthesize the available data on the effects of MS on offspring obesity, estimated indirectly by body mass (BM), body fat (BF) and plasma leptin; systolic blood pressure (SBP); plasma glucose (and insulin) and blood lipid concentrations. Methods: Literature was screened and summary estimates of the effect of MS outcomes were calculated by using random-effects models. Data on the effects of exogenous corticosteroid administration (or inhibition of 11β-HSD2) during pregnancy in rodents was analysed separately to characterize the direct phenotypic effects of prenatal corticosteroid excess (PCE). Results: We conducted 14 separate meta-analyses and synthesized relevant data on outcomes scarcely reported in literature. Both MS and PCE were associated with low birth weight without rapid catch-up growth resulting in decreased body mass later in life. Our analysis also revealed significant and contradictory effects on offspring adiposity. Little evidence was found for effects on glucose metabolism and blood lipids. We identified increased SBP in offspring exposed to PCE; however, there is not enough data to draw any conclusion about effects of MS on SBP. Conclusions: Neonatal weight proved to be decreased in offspring prenatally exposed to stress or corticosteroids, but laboratory rodents in the absence of a challenging environment did not show catch-up growth. The available evidence is inconclusive regarding the effect on adiposity revealing clear methodological and knowledge gaps. This meta-analysis also confirmed a significant positive association between PCE and SBP. Nevertheless, additional studies should address the association with MS.

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Systematic review and meta-analysis on the relationship between prenatal stress and metabolic syndrome intermediate phenotypes

Cited by 23 publications

References 68 publications

Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice

Influence of prenatal stress on metabolic abnormalities induced by postnatal intake of a high-fat diet in BALB/c mice

Resilience: Safety in the Aftermath of Traumatic Stressor Experiences

Prenatal stress and later metabolic consequences: Systematic review and meta-analysis in rodents

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