Systematic review: Effectiveness of herbal oral care products on ventilator‐associated pneumonia

Mojtahedzadeh, Mojtaba; Saberi, Mehdi; Habtemariam, Solomon; Nabavi, Seyed Mohammad; Najafi, Atabak; Ghahremanian, Amirhosein; Baktash, Mohammad; Aghaabdollahian, Safieh; Sureda, Antoni; Bagheri, Mahdi

doi:10.1002/ptr.7060

Cited by 6 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results are similar to some of the findings in a recent systematic review [53]. However, our study showed that Chamomile extract had a significant advantage over CHX in reducing Colony Number (OR: 0.63, 95% CI: 0.46-0.85), but no significant advantage over CHX in reducing the incidence of VAP (OR: 1.15, 95% CI: 0.5-2.79), which is different from the clinical trial results [23].…”

Section: Plos Onesupporting

confidence: 93%

Herbal oral care products for the prevention of ventilator-associated pneumonia: A systematic review and network meta-analysis of randomised trials

Li,

Huang,

Xie

2024

PLoS ONE

View full text Add to dashboard Cite

Background The recommendation for Chlorhexidine (CHX) as a traditional oral care solution is decreasing, and herbal oral care products are being considered as a potential alternative. This network meta-analysis aims to determine if herbal oral care products for oral care in mechanically ventilated patients are superior to CHX and provide direction for future research by comparing the effectiveness of herbal oral care products currently available. Materials and methods We searched for English-language published and grey literature sources of randomized clinical trials involving herbal oral care solutions in intensive care unit (ICU) oral care (until September 2023). The primary outcome was the incidence of ventilator-associated pneumonia (VAP); the secondary outcome was the oral microbiota quantity. Data were pooled by pairwise meta-analysis and Bayesian network meta-analysis. The risk of bias was assessed using the Cochrane risk of bias tool, and the certainty of evidence was evaluated using the GRADE framework. Results Our network meta-analysis included 29 studies, and the results showed that Chinese herb (OR: 0.39, 95% CI: 0.2–0.75) and Miswak (OR: 0.27, 95% CI: 0.07–0.91) were more effective in reducing VAP incidence than CHX. In terms of reducing bacterial counts, Chinese herb (OR: 0.3, 95% CI: 0.19–0.48) was superior to CHX, and all herbal oral care products, including Persica® (alcoholic extract of S. persica, Achillea millefolium, and Mentha spicata), Matrica® (Chamomile extract), and Listerine® (main components include Menthol, Thymol, and Eucalyptol), were better than saline in all aspects but without significant differences. Conclusion Based on our network meta-analysis, we have observed that Chinese herbal medicine and Miswak are superior to CHX in reducing the incidence of VAP. However, the safety and feasibility of traditional Chinese herbal medicine require further high-quality research for validation. Simultaneously, Matrica® demonstrates a significant reduction in microbial counts but does not exhibit a significant advantage in lowering the incidence of VAP. This observation aligns with the results of clinical double-blind trials. Therefore, we identify Miswak and Matrica® as promising herbal oral care products with the potential to replace CHX. It is essential to emphasize that our study provides guidance for future research rather than conclusive determinations. Registration PROSPERO no. CRD42023398022.

show abstract

Section: Plos Onesupporting

confidence: 93%

Herbal oral care products for the prevention of ventilator-associated pneumonia: A systematic review and network meta-analysis of randomised trials

Li,

Huang,

Xie

2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Nevertheless, all studies focused on healthy participants having gingivitis, and no study intervention used mouthwash containing constituents from A. lakoocha . A systematic review of a herbal oral care product in critically ill patients involved 18 studies with more than 10 major natural products that showed the effects of reduction of the oral microbial flora comparable to CHX 30 .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Moraceae with chlorhexidine mouthwash on the microbial flora of critically ill intubated patients: a randomized controlled pilot study

Siriyanyongwong

Teanpaisan

Pahumunto

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Critically ill intubated patients are routinely provided with chlorhexidine (CHX) for their mouth washing, but CHX mouthwash induces several complications. In this study, we aimed to evaluate the efficacy and safety of Moraceae with CHX mouthwash in the reduction of oral bacterial count in critically ill patients and to compare it with CHX-alone mouthwash. This double-blind, randomized, controlled trial included critically ill patients receiving mechanical ventilation. The patients were randomly divided into two groups based on the Modified Beck oral assessment score. The primary endpoint was a reduction in oral bacterial counts after mouth washing on day 1 and day 4. Thirty patients were included in this study; 15 patients received Moraceae with CHX mouthwash and 15 patients received CHX-alone mouthwash. The oral bacterial counts in the Moraceae with CHX group did not differ from the CHX group after mouth washing on day 1 and day 4 of admission. The patients in the CHX group experienced more intolerable taste than those in the Moraceae group (60% vs. 13.3%, P = 0.008). Moraceae with CHX mouthwash had the same effectiveness as CHX alone on bacterial flora but exhibited less intolerable side effects than CHX alone.Trial registration: TCTR20190530003; 30/05/2019.

show abstract

“…Their medicinal and physical properties make these substances intriguing. Several companies are increasing including herbal compounds in goods as a means of enhancing their medicinal properties (Mojtahedzadeh et al, 2021; Telrandhe et al, 2021). Complementary and alternative medicine (CAM) practitioners and patients are no longer on the fringes of conventional care.…”

Section: Introductionmentioning

confidence: 99%

Potential applications of medicinal herbs and phytochemicals in oral and dental health: Status quo and future perspectives

et al. 2022

View full text Add to dashboard Cite

ObjectiveHerbal therapies are utilized to treat a broad diversity of diseases all over the globe. Although no clinical studies have been conducted to demonstrate the antibacterial, antimicrobial, and antiplaque characteristics of these plants, this does not imply that they are ineffectual as periodontal treatments or anti‐cariogenic drugs. However, there is a scarcity of research confirming their efficacy and worth.SubjectHerbs are utilized in dentistry as antimicrobial, antineoplastic, antiseptic, antioxidant, and analgesics agents as well as for the elimination of bad breath. In addition, the application of herbal agents in tissue engineering improved the regeneration of oral and dental tissues. This study reviews the application of medicinal herbs for the treatment of dental and oral diseases in different aspects.MethodsThis article focuses on current developments in the use of medicinal herbs and phytochemicals in oral and dental health. An extensive literature review was conducted via an Internet database, mostly PubMed. The articles included full‐text publications written in English without any restrictions on a date.ConclusionPlants have been suggested, as an alternate remedy for oral–dental problems, and this vocation needs long‐term dependability. More research on herbal medicine potential as pharmaceutical sources and/or therapies is needed.

show abstract

Systematic review: Effectiveness of herbal oral care products on ventilator‐associated pneumonia

Cited by 6 publications

References 29 publications

Herbal oral care products for the prevention of ventilator-associated pneumonia: A systematic review and network meta-analysis of randomised trials

Herbal oral care products for the prevention of ventilator-associated pneumonia: A systematic review and network meta-analysis of randomised trials

Efficacy of Moraceae with chlorhexidine mouthwash on the microbial flora of critically ill intubated patients: a randomized controlled pilot study

Potential applications of medicinal herbs and phytochemicals in oral and dental health: Status quo and future perspectives

Contact Info

Product

Resources

About