Systematic review: Impact of resveratrol exposure during pregnancy on maternal and fetal outcomes in animal models of human pregnancy complications—Are we ready for the clinic?

Darby, Jack R. T.; Dollah, Murni H.B. Mohd; Regnault, Timothy R. H.; Williams, Marie; Morrison, Janna L.

doi:10.1016/j.phrs.2019.04.020

Cited by 33 publications

(49 citation statements)

References 99 publications

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“…A recent systematic review assessed the effects of RESV supplementation during pregnancy on maternal and offspring health outcomes in 31 studies of complicated pregnancies in animal models (Darby et al . ). Among these studies, four studies examined the effects of RESV in GDM, of which three studies used a streptozotocin‐induced diabetes model (Singh et al .…”

Section: Discussionmentioning

confidence: 97%

“…Moreover, previous studies administered RESV prior to pregnancy, as well as early in pregnancy or throughout gestation and lactation (Darby et al . ). The presrnt study is the first to supplement maternal diets with RESV at the beginning of the third trimester (i.e.…”

Section: Discussionmentioning

confidence: 97%

“…A limitation of our findings is that we did not measure parent or glucoronidated RESV levels in the maternal or fetal circulation in the present study, although this is a limitation of most previous studies of RESV administration during pregnancy (Darby et al . ). However, this is technically challenging and semiquantitative at best because samples need to be pooled to reach the level of detection (Bourque et al .…”

Section: Discussionmentioning

confidence: 97%

“…Several studies reported that maternal RESV supplementation throughout pregnancy reduced obesity, reduced hepatic triglycerides and improved insulin sensitivity in the adult offspring (Darby et al . ). However, maternal RESV altered islet architecture in the fetus, suggesting possible negative effects on insulin secretion (Roberts et al .…”

Section: Introductionmentioning

confidence: 97%

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Maternal resveratrol administration protects against gestational diabetes‐induced glucose intolerance and islet dysfunction in the rat offspring

Brawerman

Kereliuk

Brar

et al. 2019

The Journal of Physiology

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Key points Maternal resveratrol (RESV) administration in gestational diabetes (GDM) restored normoglycaemia and insulin secretion. GDM‐induced obesity was prevented in male GDM+RESV offspring but not in females. GDM+RESV offspring exhibited improved glucose tolerance and insulin sensitivity. GDM+RESV restored hepatic glucose homeostasis in offspring. Glucose‐stimulated insulin secretion was enhanced in GDM+RESV offspring. Abstract Gestational diabetes (GDM), the most common complication of pregnancy, is associated with adverse metabolic health outcomes in offspring. Using a rat model of diet‐induced GDM, we investigated whether maternal resveratrol (RESV) supplementation (147 mg kg–1 day–1) in the third week of pregnancy could improve maternal glycaemia and protect the offspring from developing metabolic dysfunction. Female Sprague–Dawley rats consumed a high‐fat and sucrose (HFS) diet to induce GDM. Lean controls consumed a low‐fat (LF) diet. In the third trimester, when maternal hyperglycaemia was observed, the HFS diet was supplemented with RESV. At weaning, offspring were randomly assigned a LF or HFS diet until 15 weeks of age. In pregnant dams, RESV restored glucose tolerance, normoglycaemia and improved insulin secretion. At 15 weeks of age, GDM+RESV‐HFS male offspring were less obese than the GDM‐HFS offspring. By contrast, the female GDM+RESV‐HFS offspring were similarly as obese as the GDM‐HFS group. Hepatic steatosis, insulin resistance, glucose intolerance and dysregulated gluconeogenesis were observed in the male GDM offspring and were attenuated in the offspring of GDM+RESV dams. The dysregulation of several metabolic genes (e.g. ppara, lpl, pepck and g6p) in the livers of GDM offspring was attenuated in the GDM+RESV offspring group. Glucose stimulated insulin secretion was also improved in the islets from offspring of GDM+RESV dams. Thus, maternal RESV supplementation during the third trimester of pregnancy and lactation induced several beneficial metabolic health outcomes for both mothers and offspring. Therefore, RESV could be an alternative to current GDM treatments.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Maternal resveratrol administration protects against gestational diabetes‐induced glucose intolerance and islet dysfunction in the rat offspring

Brawerman

Kereliuk

Brar

et al. 2019

The Journal of Physiology

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“…; Darby et al . ). Given that RSV also crosses the placenta and enters the fetal circulation in both rats (Bourque et al .…”

Section: Introductionmentioning

confidence: 97%

Subcutaneous maternal resveratrol treatment increases uterine artery blood flow in the pregnant ewe and increases fetal but not cardiac growth

Darby

Saini

Soo

et al. 2019

The Journal of Physiology

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Key points Substrate restriction during critical developmental windows of gestation programmes offspring for a predisposition towards cardiovascular disease in adult life. This study aimed to determine the effect of maternal resveratrol (RSV) treatment in an animal model in which chronic fetal catheterisation is possible and the timing of organ maturation reflects that of the human. Maternal RSV treatment increased uterine artery blood flow, fetal oxygenation and fetal weight. RSV was not detectable in the fetal circulation, indicating that it may not cross the sheep placenta. This study highlights RSV as a possible intervention to restore fetal substrate supply in pregnancies affected by placental insufficiency. Abstract Suboptimal in utero environments with reduced substrate supply during critical developmental windows of gestation predispose offspring to non‐communicable diseases such as cardiovascular disease (CVD). Improving fetal substrate supply in these pregnancies may ameliorate the predisposition these offspring have toward adult‐onset CVD. This study aimed to determine the effect of maternal resveratrol (RSV) supplementation on uterine artery blood flow and the direct effects of RSV on the fetal heart in a chronically catheterised sheep model of human pregnancy. Maternal RSV treatment significantly increased uterine artery blood flow as measured by phase contrast magnetic resonance imaging, mean gestational fetal PnormalaO2 and SnormalaO2 as well as fetal weight. RSV was not detectable in the fetal circulation, and mRNA and protein expression of the histone/protein deacetylase SIRT1 did not differ between treatment groups. No effect of maternal RSV supplementation on AKT/mTOR or CAMKII signalling in the fetal left ventricle was observed. Maternal RSV supplementation is capable of increasing fetal oxygenation and growth in an animal model in which cardiac development parallels that of the human.

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Dietary supplements and vascular function in hypertensive disorders of pregnancy

Man

Zhou

Xia

et al. 2023

Pflugers Arch - Eur J Physiol

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Hypertensive disorders of pregnancy are complications that can lead to maternal and infant mortality and morbidity. Hypertensive disorders of pregnancy are generally defined as hypertension and may be accompanied by other end organ damages including proteinuria, maternal organ disturbances including renal insufficiency, neurological complications, thrombocytopenia, impaired liver function, or uteroplacental dysfunction such as fetal growth restriction and stillbirth. Although the causes of these hypertensive disorders of pregnancy are multifactorial and elusive, they seem to share some common vascular-related mechanisms, including diseased spiral arteries, placental ischemia, and endothelial dysfunction. Recently, preeclampsia is being considered as a vascular disorder. Unfortunately, due to the complex etiology of preeclampsia and safety concerns on drug usage during pregnancy, there is still no effective pharmacological treatments available for preeclampsia yet. An emerging area of interest in this research field is the potential beneficial effects of dietary intervention on reducing the risk of preeclampsia. Recent studies have been focused on the association between deficiencies or excesses of some nutrients and complications during pregnancy, fetal growth and development, and later risk of cardiovascular and metabolic diseases in the offspring. In this review, we discuss the involvement of placental vascular dysfunction in preeclampsia. We summarize the current understanding of the association between abnormal placentation and preeclampsia in a vascular perspective. Finally, we evaluate several studied dietary supplementations to prevent and reduce the risk of preeclampsia, targeting placental vascular development and function, leading to improved pregnancy and postnatal outcomes.

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Systematic review: Impact of resveratrol exposure during pregnancy on maternal and fetal outcomes in animal models of human pregnancy complications—Are we ready for the clinic?

Cited by 33 publications

References 99 publications

Maternal resveratrol administration protects against gestational diabetes‐induced glucose intolerance and islet dysfunction in the rat offspring

Maternal resveratrol administration protects against gestational diabetes‐induced glucose intolerance and islet dysfunction in the rat offspring

Subcutaneous maternal resveratrol treatment increases uterine artery blood flow in the pregnant ewe and increases fetal but not cardiac growth

Dietary supplements and vascular function in hypertensive disorders of pregnancy

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