Systematic review of appropriate cognitive assessment instruments used in clinical trials of schizophrenia, major depressive disorder and bipolar disorder

Bakkour, Nadia; Samp, Jennifer C.; Akhras, Kasem; Hammi, Emna El; Soussi, I; Zahra, Fatma A. Abu; Duru, Gérard; Kooli, A.; Toumi, Mondher

doi:10.1016/j.psychres.2014.02.014

Cited by 67 publications

(33 citation statements)

References 77 publications

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“…However only two instruments frequently used in BD have been deemed appropriate [11]. In schizophrenia, a consensus clinical battery, The Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) has been developed with the purpose of showing practical utility, good test–retest reliability and especially potential sensitivity to treatments designed to improve cognitive function in the disorder [12].…”

Section: Introductionmentioning

confidence: 99%

Use of the MATRICS consensus cognitive battery (MCCB) to evaluate cognitive deficits in bipolar disorder: A systematic review and meta-analysis

Mao

et al. 2017

PLoS ONE

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BackgroundThe Measurement and Treatment Research to Improve Cognition Schizophrenia Consensus Cognitive Battery (MCCB) has also been proposed for use in clinical trials to assess cognitive deficits in patients with bipolar disorder (BD). The aim of this study was to evaluate cognitive function assessed by the MCCB in BD.MethodsA literature search of the PubMed, Embase, PsycINFO, SCI, Cochrane Library databases and the Cochrane Controlled Trials Register was conducted. Case reports, reviews and meta-analyses were excluded and a systematic review of the remaining studies of cognitive function in BD was carried out. The cognitive outcome measure was the MCCB, including 7 domains and overall cognition. A random-effects model was applied.ResultsEighty eight studies were initially identified. Seven clinical studies comprising a total of 487 patients and 570 healthy controls (HC) were included in the meta-analysis. Patients with BD performed worse than HC in overall cognition and processing speed with a large effect size of >0.8; with a medium effect size (0.5–0.8) in attention, working memory, verbal learning and visual learning; and with a small effect size (0.2–0.5) in reasoning and problem solving and social cognition.ConclusionPatients with BD performed worse than HC in overall cognition and all cognitive domains of the MCCB. Cognitive deficits in domains of processing speed and working memory are prominent in patients with BD. Our findings suggest that MCCB can be usefully applied in BD.

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Section: Introductionmentioning

confidence: 99%

Use of the MATRICS consensus cognitive battery (MCCB) to evaluate cognitive deficits in bipolar disorder: A systematic review and meta-analysis

Mao

et al. 2017

PLoS ONE

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“…Numerous neuropsychological testing batteries have been developed to determine the magnitude of cognitive impairment in patients with schizophrenia 9,10. For example, the well-known Measurement and Treatment Research to Improve Cognition in Schizophrenia is used in clinical trials for assessing cognitive function in patients with schizophrenia 11,12.…”

Section: Introductionmentioning

confidence: 99%

Validation of the Chinese version of Brief Assessment of Cognition in Schizophrenia

Wang¹,

Lin²,

Yu³

et al. 2016

NDT

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ObjectiveA test battery that measures cognitive function impairment in patients with schizophrenia, the Brief Assessment of Cognition in Schizophrenia (BACS), has been translated into various languages and validated. This study aimed to test the reliability and validity of the Chinese version of the BACS in a Chinese-speaking population.MethodsAll participants in this study (66 patients with schizophrenia [mean age: 41.2 years, 57.6% male] and 66 age- and sex-matched healthy controls) were from Taiwan and assessed using the BACS and the University of California, San Diego (UCSD) Performance-Based Skills Assessment, Brief Version (UPSA-B). Thirty-eight of the 66 patients with schizophrenia received a reassessment using the BACS.ResultsThe BACS had good test–retest reliability, and all BACS subtests had statistically insignificant practice effects. Principal components analysis demonstrated that a one-factor solution best fits our dataset (60.9% of the variance). In both patients and controls, the BACS composite scores were positively correlated with all BACS subscales (P<0.001) and UPSA-B scales (P<0.001). Furthermore, all BACS subtests (verbal memory, working memory, motor speed, verbal fluency, attention and processing speed, and executive function) significantly differentiated patients with schizophrenia from healthy controls (P<0.001), and the BACS composite score had the best discriminative validity (P<0.001).ConclusionThe Chinese version of the BACS exhibits satisfactory psychometric properties, including high test–retest reliability, high internal consistency, acceptable concurrent validity, and good discriminant validity. We suggest that the BACS is a reliable and practical tool for assessing cognitive function in patients with schizophrenia.

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“…Besides, it had a relatively higher specificity to distinguish the schizophrenia group from healthy individuals. Although cognitive dysfunctions are accepted as core symptoms for psychiatric disorders (1,2) and there are many tests to measure and assess cognitive functions, no consensus on appropriate and adequate tests that can be used in clinical practice exists (48). Psychiatrist have been reported to have limited use of appropriate testing in clinical practice (49).…”

Section: Discussionmentioning

confidence: 99%

Information processing abnormalities in schizophrenia and bipolar disorder

Balaban¹,

Atagün²,

Özgüven³

2018

Dusunen Adam

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Information processing abnormalities in schizophrenia and bipolar disorderObjective: Patients with bipolar disorder and schizophrenia exhibit abnormalities in attention, memory, working memory, verbal/visual learning and executive functions. However, many of the tests fail to detect slight changes in cognitive performance due to ceiling effect. It was aimed to determine sensitivity and specificity of the tests that measure information processing in schizophrenia and bipolar disorder in this study. Method: Thirty four patients with schizophrenia, 35 patients with bipolar disorder according to DSM-IV and 33 healthy control subjects matched for age, education level and gender were enrolled to the study. For clinical assessments Scale for the Assessment of Positive Symptoms, Scale for the Assessment of Negative Symptoms, Hamilton Depression Rating Scale, Young Mania Rating Scale, Clinical Global Impression Scale and Abnormal Involuntary Movements Scale were used. All participants performed a battery consisting of tests measuring information processing including Adult Memory and Information Processing Battery (AMIPB), Trail Making Test (TMT) Form A and B, Digit Symbol Coding Task (DST) and Auditory and Visual Reaction Time Tests (RTT).Results: The schizophrenia group had significantly lower performance than the healthy control group in all tests and lower performance than the bipolar disorder group in AMIPB-A and B tests, TMT A and B tests. The bipolar disorder group had lower performance than the healthy control group only in DST test. The AMIPB A and B tests were the most sensitive and specific tests in the ROC analysis. Conclusion: Changes in cognitive function might be better monitored by the tests whose sensitivity and specificity are higher. Since psychiatric disorders are highly heterogeneous, measurement tools are important for precise measurements.

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Systematic review of appropriate cognitive assessment instruments used in clinical trials of schizophrenia, major depressive disorder and bipolar disorder

Cited by 67 publications

References 77 publications

Use of the MATRICS consensus cognitive battery (MCCB) to evaluate cognitive deficits in bipolar disorder: A systematic review and meta-analysis

Use of the MATRICS consensus cognitive battery (MCCB) to evaluate cognitive deficits in bipolar disorder: A systematic review and meta-analysis

Validation of the Chinese version of Brief Assessment of Cognition in Schizophrenia

Information processing abnormalities in schizophrenia and bipolar disorder

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