Systematic review of atraumatic splenic rupture (<i>Br J Surg</i> 2009; 96: 1114–1121)

Khan, Rehan; Jindal, V.

doi:10.1002/bjs.7052

Cited by 8 publications

(7 citation statements)

References 1 publication

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“…According to the literature reviewed, approximately 200 cases have been reported; chronic myeloid leukemia appears to be one of the main causes (15.8 %) along with Hodgkin lymphoma (36.2 %). Other causes are myeloproliferative disorders (15.8 %), acute myeloid leukemia (13.8 %), acute lymphoblastic leukemia (7.9 %), and myelodysplastic disorders (7.9 %) [5].…”

Section: Discussionmentioning

confidence: 99%

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Spontaneous splenic rupture in a patient with chronic myeloid leukemia: A case report

Rueda‐Esteban

Muñoz

Díaz

et al. 2020

International Journal of Surgery Case Reports

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HighlightsSSR is mainly caused by one of three conditions: hematological malignancies, infectious diseases, and other inflammatory or neoplastic disorders.CML is one of the main causes of SSR along with Hodgkin lymphoma.Three mechanisms are believed to cause SSR: parenchymal congestion and concomitant coagulopathy, leadingto splenic hemorrhage and infarction.In only 19 % of reported cases, SSR was diagnosed correctly; most common differential diagnoses include hepatic and biliary pathologies.Timely diagnosis and treatment improves survival rate and reduces complications.

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Section: Discussionmentioning

confidence: 99%

“…Spontaneous splenic rupture (SSR) was described for the first time in 1924 [4]. SSR secondary to hematologic malignancy is rare, but among this subset of patients, chronic myeloid leukemia (CML) is one of the main causes [5]. This is a case report of a spontaneous splenic rupture secondary to severe splenomegaly in a patient with CML.…”

Section: Introductionmentioning

confidence: 99%

Spontaneous splenic rupture in a patient with chronic myeloid leukemia: A case report

Rueda‐Esteban

Muñoz

Díaz

et al. 2020

International Journal of Surgery Case Reports

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“…Spontaneous splenic rupture is rare, and accounts for 3% to 4% of the total splenic ruptures. [ 14 ] It has varied pathogenesis and etiologies, such as infectious diseases, splenic occupying diseases, hematological diseases, drug-induced events, and splenic artery aneurysm. [ 14 – 16 ] Our case was the first with pathologically-proven splenic TMA induced by MHT and based on the direct pathological characteristics of the spleen, such as hyaline degeneration in the small artery wall, focal fibrous necrosis, thrombosis, and partial small vessel occlusion.…”

Section: Discussionmentioning

confidence: 99%

“…[ 14 ] It has varied pathogenesis and etiologies, such as infectious diseases, splenic occupying diseases, hematological diseases, drug-induced events, and splenic artery aneurysm. [ 14 – 16 ] Our case was the first with pathologically-proven splenic TMA induced by MHT and based on the direct pathological characteristics of the spleen, such as hyaline degeneration in the small artery wall, focal fibrous necrosis, thrombosis, and partial small vessel occlusion. In theory, MHT could damage the micro-endothelial cells of viscera such as spleen by elevated shear stress, inflammation, over-activation of complement, aberrant coagulation “storm” and so on, besides the more often targeted organs like kidney, brain and heart.…”

Section: Discussionmentioning

confidence: 99%

A rare case of malignant hypertension with splenic rupture and thrombotic microangiopathy

Ding

2020

Medicine

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Introduction: Thrombotic microangiopathy (TMA) is characterized by endothelial injury followed by formation of multiple microthrombi in the target organs due to various causes, including malignant hypertension (MHT). Here, we reported a rare case of MHT with splenic TMA changes. Case concerns: A 27-year-old Chinese Han male with a history of hypertension and proteinuria, admitted to our hospital because of renal failure with MHT and thrombocytopenia. Diagnosis: This case diagnosed with TMA based on the patient's MHT and thrombocytopenia. The patient final diagnosis was confirmed by the spleen pathological findings, other differential diagnoses were ruled out. Interventions: The patient was treated with hemodialysis and intravenous antihypertensive agents, and his condition gradually improved. However, he suddenly complained of abdominal pain and went into hemorrhagic shock, which was due to spontaneous spleen rupture on the third day of hospitalization. The pathological evidence after splenectomy showed splenic TMA. Outcomes: Hemodialysis was continued and the blood pressure was under control until his discharge from our hospital. Conclusion: Spontaneous splenic rupture could be a rare and critical complication associated with MHT-induced TMA, and it requires careful clinical attention.

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“…Novel oral anticoagulants (NOACs) are more preferred today. Non-traumatic, spontaneous splenic rupture is very rare and especially life-threatening if not immediately recognized 1,2 . Although organ-specific bleeding is much rare with NOACs compared to warfarin use, there is still a risk of intracranial bleeding and gastrointestinal (GI) bleeding 3 .…”

Section: Introductionmentioning

confidence: 99%

Spontaneous Spleen Rupture and Apixaban

Yildirim

Acar

Demir

et al. 2020

Journal of Emergency Medicine Case Reports

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Novel oral anticoagulants (NOACs) are now widely used. Spontaneous splenic rupture (SLR) is a rare condition. It is life-threatening, especially if not immediately recognized. Previous studies have shown an association between NOAC use and SLR. We report a case of 53-year-old female patient who responded to cardiopulmonary resuscitation (CPR) after SLR. The patient, who had an external cardiac device for heart failure 13 months ago was admitted to our emergency department. She was unconscious, pale, hypotensive and had tachycardia. Free fluid was detected in the peritoneum by bedside ultrasonography. The patient was resuscitated for 20 minutes after arrest during the follow-up period. She was stabilized and computed tomography showed a large subcapsular splenic hematoma with active extravasation around the spleen, but persistent low urine output developed with hypotension despite resuscitation. She was taken to the operating room for splenectomy and abdominal washing. She was then recovered and discharged 17 days later. We wanted to draw attention to a patient with SLR due to NOACs. Rapid diagnosis and aggressive early resuscitation are critical in the management of NOAC associated SLR.

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Systematic review of atraumatic splenic rupture (Br J Surg 2009; 96: 1114–1121)

Cited by 8 publications

References 1 publication

Spontaneous splenic rupture in a patient with chronic myeloid leukemia: A case report

Spontaneous splenic rupture in a patient with chronic myeloid leukemia: A case report

A rare case of malignant hypertension with splenic rupture and thrombotic microangiopathy

Spontaneous Spleen Rupture and Apixaban

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