Systematic review of severe fever with thrombocytopenia syndrome:virology, epidemiology, and clinical characteristics

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) was firstly discovered in China in 2010, followed by several reports from many other countries worldwide. SFTS virus (SFTSV) has been identified as the causative agent of the disease and has been recognized as a public health threat. This novel Bunyavirus belongs to the Phlebovirus genus in the family Bunyaviridae. This review also describes the different aspects of virology, pathogenesis, epidemiology, and clinical symptoms on the basis of the published article surveillance data and phylogenetic analyses of viral sequences of large, medium, and small segments retrieved from database using mega 5.05, simplot 3.5.1, network 4.611, and epi information system 3.5.3 software. SFTS presents with fever, thrombocytopenia, leukocytopenia, and considerable changes in several serum biomarkers. The disease has 10 ∼ 15% mortality rate, commonly because of multiorgan dysfunction. SFTSV is mainly reported in the rural areas of Central and North-Eastern China, with seasonal occurrence from May to September, mainly targeting those of ≥50 years of age. A wide range of domesticated animals, including sheep, goats, cattle, pigs, dogs, and chickens have been proven seropositive for SFTSV. Ticks, especially Haemaphysalis longicornis, are suspected to be the potential vector, which have a broad animal host range in the world. More studies are needed to elucidate the vector–animal–human ecological cycle, the pathogenic mechanisms in high level animal models and vaccine development. © 2013 The Authors. Reviews in Medical Virology published by John Wiley & Sons, Ltd.

Presence of Antibodies against Severe Fever with Thrombocytopenia Syndrome Virus in Non-Endemic Areas of China

“…Our study showed that the seropositivity rate of SFTSV-IgG antibodies among participants in Yixian country was 6.3%, which was higher than the reported rate of 4.66% in endemic areas of Anhui Province (21). This discrepancy may be related to the number involved, age, sex, geographic location, and types of antibodies tested (total antibodies or IgG antibodies against SFTSV) (22).…”

Fatal Severe Fever with Thrombocytopenia Syndrome: An Autopsy Case Report

“…It has a seasonal occurrence from May to September and mainly targets those of ! 50 years of age (2). Cases of SFTS in Japanese patients with a higher fatality rate (55%) are very similar to the severe cases reported in Chinese patients (3), however, there have been only three published autopsy cases reporting pathological analyses for the disease progression to death of SFTS (3,4).…”

Clinical profile of patients with thrombocytopenia at tertiary health care centre

“…dengue (30%), malaria (20.83%), enteric fever (5%) HIV (4.16%) followed by megaloblastic anemia (21.66%). Similar findings were also noted in systematic review by Liu Shelan et al 7 In our study, 25 patients (20.83%) received blood transfusion out of that 14 patients had platelet count less than 10000/mm 3 and 11 patients had platelet count more than 10000/mm 3 . In our study we had noted highest and lowest platelet count in male and female patient but there was no significant difference between sex and platelet count.…”