Systematic review of studies exploring reasons for statin non-adherence and of randomised controlled trials of interventions to improve adherence

Logue, Jennifer; AL-Ghibiwi, H.; Alamri, Abdulmajeed; Preiss, David

doi:10.1016/j.atherosclerosis.2015.04.185

Cited by 5 publications

(2 citation statements)

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“…Even though simvastatin has a slightly better lipid-lowering effect when taken in the evening instead of in the morning, other factors such as compliance and non-lipid effects of statins may weaken the recommendation to give statins as evening medication 35 ) . Recent meta-analysis suggested that the main reasons for statin non-adherence included forgetfulness 36 ) . In this aspect, simplifying administration timing might be a very effective strategy to improve statin adherence.…”

Section: Discussionmentioning

confidence: 99%

Medication Adherence Improvement By Using Administration Timing Simplification Protocol (ATSP) in Cardiovascular Disease Patients

Lee

Kim

Park

et al. 2017

J Atheroscler Thromb

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Aims: In chronic diseases, keeping adherence to medication is very difficult. The objective of this study was to evaluate the impact of administration timing simplification protocol (ATSP) on medication adherence and clinical parameters of cardiovascular diseases.Methods: 210 out-patients with cardiovascular disease, who were taking two or more pills of any type of medication per day for more than one year, were enrolled and randomized. The intervention group followed the simplified administration schedule of ATSP with two main strategies: 1) moving medication from “pc” (30 minute after meal) to “stat. pc” (immediately after meal); and 2) moving medication time from “at evening” to “at morning.” In contrast, the control group maintained the same medication schedule. Both patient groups were equally educated about the names and effects of the medication.Results: The intervention group had more pills than the control group with marginal statistical significance (5.1 ± 2.3 vs 4.6 ± 1.8, p = 0.05). The total frequency of administration was significantly higher in the intervention group than that of the control group (2.9 ± 1.0 vs 2.6 ± 0.9, p = 0.03) at the baseline. In the intervention group, the frequency was significantly decreased to 1.5 ± 0.6 times per day after following ATSP application (p < 0.01). In both patient groups, knowledge about the medication was significantly improved by education. However, medication adherence was only improved in the intervention group. Interestingly, total cholesterol was significantly decreased in the intervention group (p < 0.01). The decrease in serum cholesterol concentration was significantly correlated with the improvement in medication adherence evaluated with Morisky Medication Adherence Scale (MMAS)-8 items (r = 0.507, p < 0.01).Conclusion: ATSP was shown to be an effective strategy to improve medication adherence in chronic cardiovascular disease patients.

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Section: Discussionmentioning

confidence: 99%

Medication Adherence Improvement By Using Administration Timing Simplification Protocol (ATSP) in Cardiovascular Disease Patients

Lee

Kim

Park

et al. 2017

J Atheroscler Thromb

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“…Based on the results of clinical tests, these drugs reduce the risk of coronary artery disease and thus reduce the overall mortality rate of heart patients. Available statistics regarding the matter show their desirable effects on the dramatic reduction, by 42%, in deaths from coronary artery diseases in people with high LDL [ 33 , 34 ].…”

Section: Statinsmentioning

confidence: 99%

A Review of the Role of Statins in Heart Failure Treatment

Niazi

Galehdar

Jamshidi

et al. 2020

CCP

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Background: Heart failure is a common medical problem in the world, which has a high prevalence in both developed and developing countries. Today, among the medications used for the heart failure treatment, there are many medications with a positive cardiac contraction effect (positive inotropic such as digital glycosides, adrenergic receptor stimulants, and phosphodiesterase inhibitors), a large number of cardiac diluents (such as Angiotensin-Converting Enzyme (ACE) inhibitor group), and a few other types of drugs whose final effects are still under review. Statins are valuable drugs that are broadly prescribed in hyperlipidemia and cardiovascular patients due to their multiple properties, such as cholesterol reduction, endothelial function improvement, antioxidative, anti-inflammatory, neovascularization, and immunomodulatory activities. Methods: There is evidence that the therapeutic role of statins in HF, due to myocardial hypertrophy, show reduction in cardiomyocyte loss in the apoptosis process, oxidative stress, inflammation, and also the return of neurohormonal imbalance. However, the fact that these drugs have no sideeffects has not been confirmed in all studies, as statins prevent the production of particular beneficial and protective factors, such as coenzyme Q10 (CoQ10), while inhibiting the production of specific proteins involved in pathologic mechanisms. Results: Recently, it has been hypothesized that, despite the positive effects reported, high doses of statins in patients with long-term heart failure lead to progress in heart failure by inhibiting CoQ10 synthesis and intensifying hypertrophy. Conclusion: Thus, it can be stated that the advantage of using statins depends on factors, such as stroke fraction, and the existence of other standard indications such as atherosclerotic diseases or high Low-Density Lipoprotein-C (LDL-C).

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Interventions for improving modifiable risk factor control in the secondary prevention of stroke

Bridgwood

Lager

Mistri

et al. 2018

Cochrane Database of Systematic Reviews

109

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Systematic review of studies exploring reasons for statin non-adherence and of randomised controlled trials of interventions to improve adherence

Cited by 5 publications

References 0 publications

Medication Adherence Improvement By Using Administration Timing Simplification Protocol (ATSP) in Cardiovascular Disease Patients

Medication Adherence Improvement By Using Administration Timing Simplification Protocol (ATSP) in Cardiovascular Disease Patients

A Review of the Role of Statins in Heart Failure Treatment

Interventions for improving modifiable risk factor control in the secondary prevention of stroke

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