Systematic review of studies on drug-delivery systems for management of temporomandibular-joint osteoarthritis

Barry, Florent; Chai, Feng; Chijcheapaza-Flores, Henry; Garcia-Fernandez, Maria José; Blanchemain, Nicolas; Nicot, Romain

doi:10.1016/j.jormas.2021.08.003

Cited by 11 publications

(14 citation statements)

References 21 publications

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“…Such persistent pain is a necessary criterion for validation of a model in studies of sustained-release DDSs. In this context, MIA and Col-2 met this criterion [ 21 , 32 ]. Our results for MIA injection are in accordance with those in recent studies of an MIA-induced model of TMJOA [ 37 ], but our results for the creation of a Col-2-induced model of TMJOA are novel.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, MIA maintained a constant action on pain behavior in the TMJOA model. This is an important feature to consider in the choice of agent to create a model for testing a DDS, because the model must be as stable as possible over time to ensure that pain relief is from the prolonged action of the drug and not from a decrease in OA [ 21 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…To overcome these problems, researchers are seeking to develop delivery systems that release drugs over a prolonged period after intra-articular injection [ 20 – 22 ]. Our latest systematic review of the literature on this subject [ 21 ] revealed that numerous types of drug-delivery system (DDS) have been investigated, such as poly(lactic- co -glycolic acid)-based biomaterials [ 23 – 25 ], hydrogels [ 26 ], microneedle patches [ 27 ], nanostructured lipid carriers [ 28 , 29 ], and poloxamer micelles [ 30 ] as carrier molecules, as well as NSAIDs, HA, and analgesic agents as bioactive molecules. There is a growing interest in the development of such therapeutic methods, and they are being tested in vitro and in vivo [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems

et al. 2023

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Objective To compare two agents that can induce a rat model of temporomandibular joint osteoarthritis (TMJOA) by chemical induction: monosodium iodoacetate (MIA) and collagenase type 2 (Col-2). We wished to ascertain the best agent for assessing drug-delivery systems (DDSs). Method Male Wistar rats underwent intra-articular injection with MIA or Col-2. They were manipulated for 30 days. The head withdrawal threshold (HWT), immunohistological assessment, and positron emission tomography (PET) were used to evaluate the relevance of our models. Results For both the MIA and Col-2 groups, pain persisted for 30 days after injection. Change in the HWT showed that Col-2 elicited a strong action initially that decreased progressively. MIA had a constant action upon pain behavior. Histology of TMJ tissue from both groups showed progressive degradation of TMJ components. Conclusions MIA and Col-2 induced orofacial pain by their local chemical action on TMJs. However, based on a prolonged and greater sustained effect on the pain threshold, persistent histological changes, and imaging results, MIA appeared to be more suitable for creation of a rat model of TMJOA for the study of DDSs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems

et al. 2023

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“…To enhance the beneficial properties of the NSAIDs, naproxen is incorporated in nanostructured lipid carriers (NLC) for intra-articular injection for the reduction of inflammation in TMJ disorders [ 28 ]. Naproxen and a nanostructured lipid carrier were used in combination where naproxen was the active molecule in the carrier system with successful results obtained from rats [ 28 ]. Naproxen mainly targets cyclooxygenase-1 and 2 (COX) which causes the production of PGE2 which then further leads to inflammatory reactions.…”

Section: Temporomandibular Joint Disordersmentioning

confidence: 99%

Nano Drug Delivery Platforms for Dental Application: Infection Control and TMJ Management—A Review

et al. 2021

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The oral cavity is an intricate environment subjected to various chemical, physical, and thermal injuries. The effectiveness of the local and systemically administered drugs is limited mainly due to their toxicities and poor oral bioavailability that leads to the limited effectiveness of the drugs in the target tissues. To address these issues, nanoparticle drug delivery systems based on metals, liposomes, polymeric particles, and core shells have been developed in recent years. Nano drug delivery systems have applications in the treatment of patients suffering from temporomandibular joint disorders such as preventing degeneration of cartilage in patients suffering from rheumatoid arthritis and osteoarthritis and alleviating the pain along with it. The antibacterial dental applications of nano-drug delivery systems such as silver and copper-based nanoparticles include these agents used to arrest dental caries, multiple steps in root canal treatment, and patients suffering from periodontitis. Nanoparticles have been used in adjunct with antifungals to treat oral fungal infections such as candida albicans in denture wearers. Acyclovir being the most commonly used antiviral has been used in combination with nanoparticles against an array of viral infections such as the herpes simplex virus. Nanoparticles based combination agents offer more favorable drug release in a controlled manner along with efficient delivery at the site of action. This review presents an updated overview of the recently developed nanoparticles delivery systems for the management of temporomandibular joint disorders along with the treatment of different oral infections.

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“…After a new episode of TMD, 27% of people persist with significant pain one year later [ 5 , 6 , 7 ], and recurrence is common [ 8 ]. Its related pain and disability bring direct (e.g., use of medication to alleviate symptoms) and indirect (e.g., productivity loss) costs [ 9 , 10 , 11 , 12 , 13 ]; therefore, effective management of the condition is important.…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Manual Therapy Approaches on Pain, Maximum Mouth Opening and Disability in Temporomandibular Disorders: A Systematic Review of Randomised Controlled Trials

Vieira

Pestana

Miranda

et al. 2023

Life

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Temporomandibular disorder (TMD) is a common condition disabling people and bringing up costs. The aim of this study was to investigate the effects of manual therapy on pain intensity, maximum mouth opening (MMO) and disability. Searches were conducted in six databases for randomised controlled trials (RCTs). Selection of trials, data extraction and methodological quality assessment were conducted by two reviewers with discrepancies resolved by a third reviewer. Estimates were presented as mean differences (MDs) or standardized mean differences (SMDs) with 95% confidence intervals (CIs). Quality of the evidence was assessed using the GRADE approach. Twenty trials met the eligibility criteria and were included. For pain intensity, high and moderate quality evidence demonstrated the additional effects of manual therapy at short- (95% CI −2.12 to −0.82 points) and long-term (95% CI −2.17 to −0.40 points) on the 0–10 points scale. For MMO, moderate to high quality evidence was found in favour of manual therapy alone (95% CI 0.01 to 7.30 mm) and its additional effects (95% CI 1.58 to 3.58 mm) at short- and long-term (95% CI 1.22 to 8.40 mm). Moderate quality evidence demonstrated an additional effect of manual therapy for disability (95% CI = −0.87 to −0.14). Evidence supports manual therapy as effective for TMD.

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Systematic review of studies on drug-delivery systems for management of temporomandibular-joint osteoarthritis

Cited by 11 publications

References 21 publications

Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems

Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems

Nano Drug Delivery Platforms for Dental Application: Infection Control and TMJ Management—A Review

The Efficacy of Manual Therapy Approaches on Pain, Maximum Mouth Opening and Disability in Temporomandibular Disorders: A Systematic Review of Randomised Controlled Trials

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