Systematic Review of the Long-Term Effects of Transgender Hormone Therapy on Bone Markers and Bone Mineral Density and Their Potential Effects in Implant Therapy

Delgado-Ruíz, Rafael Arcesio; Swanson, Patricia; Romanos, Georgios E.

doi:10.3390/jcm8060784

Cited by 25 publications

(17 citation statements)

References 72 publications

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“…Today, three-dimensional porous scaffolds can be produced that possess shape memory effects for bone tissue engineering. Both in vitro and in vivo studies revealed a significant influence of scaffold order and symmetry onto cell differentiation and proliferation [223][224][225][226][227]. Although, the systemic effect of the immune system can reject the biomaterial and that could lead to failure in vivo, this effect is not further considered and discussed.…”

Section: Scaffolds Used In Osteoporosis Treatmentmentioning

confidence: 99%

Therapeutic Treatments for Osteoporosis—Which Combination of Pills Is the Best among the Bad?

Tonk

Shoushrah

Babczyk

et al. 2022

IJMS

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Osteoporosis is a chronical, systemic skeletal disorder characterized by an increase in bone resorption, which leads to reduced bone density. The reduction in bone mineral density and therefore low bone mass results in an increased risk of fractures. Osteoporosis is caused by an imbalance in the normally strictly regulated bone homeostasis. This imbalance is caused by overactive bone-resorbing osteoclasts, while bone-synthesizing osteoblasts do not compensate for this. In this review, the mechanism is presented, underlined by in vitro and animal models to investigate this imbalance as well as the current status of clinical trials. Furthermore, new therapeutic strategies for osteoporosis are presented, such as anabolic treatments and catabolic treatments and treatments using biomaterials and biomolecules. Another focus is on new combination therapies with multiple drugs which are currently considered more beneficial for the treatment of osteoporosis than monotherapies. Taken together, this review starts with an overview and ends with the newest approaches for osteoporosis therapies and a future perspective not presented so far.

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Section: Scaffolds Used In Osteoporosis Treatmentmentioning

confidence: 99%

Therapeutic Treatments for Osteoporosis—Which Combination of Pills Is the Best among the Bad?

Tonk

Shoushrah

Babczyk

et al. 2022

IJMS

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“…Questions related to bone health are also discussed, as in the study by Delgado-Ruiz et al (2019). They analyzed the long-term effects of drug therapy on bone health parameters and bone mineral density in transgender patients.…”

Section: Scientific Evidence Involving Health and Gender Identitymentioning

confidence: 99%

Gender identity: Deconstructions and reconstructions for approaches in health / Identidade de gênero: Desconstruções e reconstruções para abordagens na saúde

Cardoso¹,

Monteiro²,

Mezzavilla³

et al. 2022

BJDV

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Objective: to elucidate publications and indicate reflections that describe and discuss the "state of the art", involving trans people and important agendas of the transsexualization process in health. Method: narrative review, with literature published in books and scientific evidence, as well as information on bills, resolutions and decrees, with reflections on the main historical perspectives, epistemological and contemporary aspects involving transgender people. Development: gender identity contemplates the essentialist, constructivist and post-structuralist perspective. In the post-structuralist perspective, gender would be a mechanism through which the notions of masculine and feminine are built, to be a woman is to become a woman insofar as the body is forced to correspond to a historical model of woman, materializing itself even within certain conditions, limits and possibilities delimited by culture. Over the decades, some rights have been achieved with the emergence of new forms of recognition of different gender identities. In the United States, in the National Transgender Discrimination Survey, one of the “Gender Not Listed Here” questions is already being considered. In Germany, the option "diverse" as a gender category, in certificates and other documents, is already part of the routine, including highlighting that binary designations would be discriminatory and violate guarantees of individual freedom. In Austria, for example, there is the option to register as a non-binary person since 2018, through the European Convention on Human Rights. In Japan, the gender considered X refers to a non-binary identity, known as an alternative to man and to woman. In Australia, the option of gender, in the passport, has already made possible some alternatives since 2003. In Brazil, some advances in ensuring respect for the gender identity of trans people can be highlighted. In 2018, a decision of the Federal Supreme Court authorized the change of the civil registry name and biological sex, without the need for surgery or a psychiatric report, dispensing with the opening of legal proceedings, and the procedure can be carried out directly at the notary's office. Science-based health is also a relevant issue and over the past 10 years, health research involving gender identity has increased significantly. This is inevitably reflected in care protocols, materials provided by the SUS, consensus and clinical guidelines. There are important data on the cardiometabolic vulnerability of the trans population, dermatoses, bone susceptibility, among other demands, due to hormone. In addition, health professionals, in most cases, are not trained with this type of content and the situation follows a vicious cycle. Final considerations: it is interesting to note how access to healthcare technologies, such as transgenitalization surgery or hormone, influence transgender identities, research about the construction of political identities, movements, highlighting the influence of social indicators of class and generation in the conflicts related to the identities of the transsexual woman and the non-binary trans. The text brings fundamental reflections and allows health professionals to acquire and update their knowledge on this topic in a short period of time.

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“…Esta população tende a ter alterações bucais, de etiologia multifatorial podendo se derivar desde o uso terapia hormonal utilizada por pacientes com disforia de gênero 12 , até o abuso de substâncias, transtornos alimentares, transtornos depressivos e/ou ansiosos e infecções sexualmente transmissíveis. O cirurgião-dentista deve estar apto a diagnosticar e tratar tais patologias, a fim de promover a cura de seus pacientes e orientá-los quanto aos fatores de risco para prevenir recidivas das lesões orais 13 .…”

Section: Introductionunclassified

População LGBTQIA+

et al. 2022

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A população LGBTQIA+ ainda hoje sofre com o preconceito e estigma, o que pode dificultar o acesso aos serviços de saúde, aumentando a presença de morbidades neste grupo. O objetivo deste estudo foi realizar uma revisão de literatura com dois enfoques: o acesso aos serviços de saúde e odontológicos por pacientes LGBTQIA+ e quais as medidas educacionais que estão sendo implementadas com alunos dos cursos de Odontologia para diminuir o estigma sobre essa população e universalizar o acesso ao tratamento odontológico. Foi realizada uma revisão de literatura de estudos publicados entre 1995 e 2020 nas bases de dados PubMed, SciELO e Google Scholar. Foram selecionados 19 artigos, relatando principalmente aspectos das experiências de acesso à saúde bucal por pacientes LGBTQIA+; a experiência dos alunos de graduação em Odontologia com essa população; a inserção de atividades focadas na desmistificação desta população em cursos de graduação e o suporte fornecido pelas instituições de ensino aos alunos que se identificam como LGBTQIA+. Apenas dois estudos foram conduzidos no Brasil. Existem evidências provenientes principalmente de estudos internacionais para afirmar que a população LGBTQIA+ possui menor acesso aos serviços de saúde e há uma falta de preparo formal dos alunos de graduação para o atendimento destas pessoas.

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Systematic Review of the Long-Term Effects of Transgender Hormone Therapy on Bone Markers and Bone Mineral Density and Their Potential Effects in Implant Therapy

Cited by 25 publications

References 72 publications

Therapeutic Treatments for Osteoporosis—Which Combination of Pills Is the Best among the Bad?

Therapeutic Treatments for Osteoporosis—Which Combination of Pills Is the Best among the Bad?

Gender identity: Deconstructions and reconstructions for approaches in health / Identidade de gênero: Desconstruções e reconstruções para abordagens na saúde

População LGBTQIA+

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