Systematic review: the application of molecular pathogenesis to prevention and treatment of oesophageal adenocarcinoma

Peters, Christopher J.; Fitzgerald, Rebecca C.

doi:10.1111/j.1365-2036.2007.03325.x

Cited by 18 publications

(11 citation statements)

References 141 publications

(271 reference statements)

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“…Several differential proteins involved in immune responses and related to angiogenesis were also detected. These results indicate that the development of ESCC is multi-factor progress; many proteins and pathways are involved in and binding functions are affected greatly by carcinogenesis [6,25,26]. Eight of the differentially expressed proteins corresponding to the following criteria were selected to validate the proteomic results by western blot and immunohistochemistry : (1) not yet or seldom reported in ESCC, (2) commercial antibody provided, (3) up-regulated, and (4) related to tumorigenesis and/or development.…”

Section: Discussionmentioning

confidence: 97%

Identification of the up-regulation of TP-alpha, collagen alpha-1(VI) chain, and S100A9 in esophageal squamous cell carcinoma by a proteomic method

Fan

Gao

Wang

et al. 2012

Journal of Proteomics

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Section: Discussionmentioning

confidence: 97%

Identification of the up-regulation of TP-alpha, collagen alpha-1(VI) chain, and S100A9 in esophageal squamous cell carcinoma by a proteomic method

Fan

Gao

Wang

et al. 2012

Journal of Proteomics

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“…A number of events occur in patients who have EADC or ESCC, at both a mechanical and a cellular level, as the process of carcinogenesis unfolds 45, 46. Although ESCC and EADC differ in their histology and epidemiologic distribution, many of their risk factors and mechanisms of carcinogenesis are the same 47…”

Section: Discussionmentioning

confidence: 99%

The severity of duodeno‐esophageal reflux influences the development of different histological types of esophageal cancer in a rat model

Miyashita

Miwa

Fujimura

et al. 2012

Intl Journal of Cancer

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The mechanism through which each histological type of carcinoma arises from the esophageal mucosa remains unknown. This study was designed to investigate whether there is an association between the severity of duodeno-esophageal reflux and the histological type of esophageal cancer. A series of 120 male Fischer rats, weighing~180 g, were randomized to receive one of the following procedures: duodeno-forestomach reflux (DFR) with reduced exposure to duodenal contents, duodeno-esophageal reflux (DER) with increased exposure to duodenal contents and three control operations (DFR, DER control and sham). The reflux of bile was estimated with 99m Tc-PMT scintigraphy. All animals were fed a standard diet without carcinogen. The esophageal mucosa was assessed 50 weeks after surgery for carcinoma. The median scanned fraction rate of duodeno-esophageal reflux was significantly lower for the rodents in the DFR group than those in the DER group. Five of 28 rodents in the DFR group and 17 of the 22 rodents in the DER group developed esophageal carcinoma. None of the controls developed carcinoma. The five rodents in the DFR group developed SCC. Of 22 esophageal carcinomas for the DER group, nine were SCC, 12 ADC and one was adenosquamous carcinoma. The fraction of esophageal SCC for the DFR group was significantly higher than that for the DER group, while the fraction of esophageal ADC for the DFR group was significantly lower than that for the DER group. These observations suggest that the severity of duodeno-esophageal reflux in rodents is related to the development of different histological types of esophageal carcinoma.Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EADC) are the two main histological types of esophageal cancer. 1 Population based studies in the Western world have shown steady and rapid rise in the incidence of EADC. 1,2 In contrast, the incidence of ESCC, the most common histological type of cancer in the Eastern world, remains stable. 3 The cause of the increased incidence of esophageal cancer remains obscure.A rise in EADC may be related to an increase in the incidence of gastroesophageal reflux disease (GERD) over the past few decades. Population studies have demonstrated a strong and causal relation between GERD and risk of developing EADC. 4 Data from a large multicenter US study identified four major risk factors for EADC: GERD, obesity [as measured by body mass index (BMI)], cigarette smoking and a diet low in fruits and vegetables. 4,5 The progression of GERD to EADC involves the initial development of inflammation induced hyperplasia and metaplasia at the gastro-esophageal junction. This is followed by multifocal dysplasia and ADC. 6 The relationship between ESCC and GERD has not been investigated or reported. Prior studies support the hypothesis that GERD plays a role in laryngopharyngeal carcinogenesis. 7,8 A population-based cohort study of patients who underwent gastrectomy for peptic ulcer disease showed a long-term increased risk of laryngeal and pharyngeal cancer....

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“…Elucidation of these pathways has led to the development of targeted therapies that can potentially inhibit or reverse the progression of invasive disease, and this has presented new opportunities in the design of clinical trials [95,96] . The epidermal growth factor receptor (ErbB1 or EGFR) and the ErbB2 (HER2/neu) receptor represent the two main members of the tyrosine kinase type ErbB-receptor family.…”

Section: Targeted Therapy In Esophageal Cancermentioning

confidence: 99%

Treatment options for esophageal cancer

Murphy

Ravi²,

Reynolds³

2008

Expert Opinion on Pharmacotherapy

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There is considerable controversy over the level of evidence from randomized trials underpinning management decisions for patients presenting with localized cancer of the esophagus and esophago-gastric junction. There is also an optimism that new drugs and new approaches, including response prediction based on sequential 18 FDG-PET scanning following induction chemotherapy, may improve treatments pathways and outcomes. In this review we assess the level of evidence from the major published trials, and discuss new trials and approaches.

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Systematic review: the application of molecular pathogenesis to prevention and treatment of oesophageal adenocarcinoma

Abstract: SUMMARY BackgroundOesophageal adenocarcinoma is an increasingly common cancer with a poor prognosis. It develops in a stepwise progression from Barrett's metaplasia to dysplasia, and then adenocarcinoma followed by metastasis.

Cited by 18 publications

References 141 publications

Identification of the up-regulation of TP-alpha, collagen alpha-1(VI) chain, and S100A9 in esophageal squamous cell carcinoma by a proteomic method

Identification of the up-regulation of TP-alpha, collagen alpha-1(VI) chain, and S100A9 in esophageal squamous cell carcinoma by a proteomic method

The severity of duodeno‐esophageal reflux influences the development of different histological types of esophageal cancer in a rat model

Treatment options for esophageal cancer

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