Digital economy has become a new direction with lots of potentials for the world economy as well asVietnam. Digital transformation is the process in which people change the way people live, work, and produce with digital technologies. To do that, it is necessary to make a change in both management methods and practical teaching in universities. That is, universities must apply modern information technology to meet the increasing learning needs of students and faculty, creating a learning environment where everything is connected. This is an ecosystem that combines technology, services and security to bridge the digital divide. That will create collaborative, interactive, and personalized learning experiences. Digital transformation is the transition from a traditional way of living, working to a way of living and working with both digital versions of entities and their connections in digital spaces. The study aims to analyze the need for the formation of a digital economy training field to create high-quality human resources to operate in the digital economy environment. Research uses a combination of qualitative research methods and quantitative research. In particular, qualitative research using in-depth interview method for experts including leaders, managers at universities, business managers. The aim is to explore the influencing aspects of the industrial revolution 4.0 on the human resource training process to respond to businesses in the digital transformation landscape. Next, quantitative studies are carried out to analyze and evaluate the relationship between training process and labor supply for enterprises in order to adapt to the digital transformation context. The article also gives comments and recommendations on solutions to innovate training activities to adapt to the digital transformation trend.