Systemic Abnormalities in Migraine

Marmura, Michael J.

doi:10.1097/nrl.0b013e31817781e0

Cited by 3 publications

(2 citation statements)

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“…Migraine is associated with many comorbid central and peripheral disorders, such as ischemic stroke, Raynaud phenomenon, epilepsy, depression, anxiety, obesity, and possibly metabolic syndrome (Guldiken et al, 2009; Buse et al, 2010). The interplay and causality of migraine and its comorbid disorders is not well understood (Marmura, 2009), particularly in regard to migraine’s association with obesity and metabolic syndrome.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Syndrome and Migraine

Sachdev¹,

Marmura²

2012

Front. Neur.

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Migraine and metabolic syndrome are highly prevalent and costly conditions. The two conditions coexist, but it is unclear what relationship may exist between the two processes. Metabolic syndrome involves a number of findings, including insulin resistance, systemic hypertension, obesity, a proinflammatory state, and a prothrombotic state. Only one study addresses migraine in metabolic syndrome, finding significant differences in the presentation of metabolic syndrome in migraineurs. However, controversy exists regarding the contribution of each individual risk factor to migraine pathogenesis and prevalence. It is unclear what treatment implications, if any, exist as a result of the concomitant diagnosis of migraine and metabolic syndrome. The cornerstone of migraine and metabolic syndrome treatments is prevention, relying heavily on diet modification, sleep hygiene, medication use, and exercise.

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Section: Introductionmentioning

confidence: 99%

Metabolic Syndrome and Migraine

Sachdev¹,

Marmura²

2012

Front. Neur.

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“…The interactions and associations between migraine and its comorbid disorders are not completely understood (5). The vasculature associated with migraine is probably not limited to the meningeal arteries, and it may share the same etiologic pathway with other cardiovascular diseases (6).…”

Section: Introductionmentioning

confidence: 99%

Serum Lipid Profiles, Relationship Between Paraoxonase/Arylesterase Activity and High-density Lipoprotein Levels in Patients with Migraine

Eren¹,

Dirik²,

Neşeli̇oğlu³

et al. 2017

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Objective: Paraoxonase 1 (PON1) is associated with high-density lipoprotein (HDL) and inhibits low-density lipoprotein (LDL) oxidation. The antioxidant and antiatherogenic characteristics of HDL are attributed to this feature. The mechanisms defined in the vascular atherosclerotic process, such as inflammation, oxidative stress, and endothelial dysfunction, are also present in migraine pathophysiology. The association between hyperlipidemia and migraine has been described in various studies; however, different results have been reported. We aimed to evaluate the general lipid profiles and the relationship between PON1, arylesterase (ARE) activity, and HDL levels in patients with migraine. Materials and Methods:The study group comprised 150 patients with migraine. The control group included 71 age-and sex-matched healthy subjects. None of the subjects in either group had any vascular risk factors. PON1 and ARE activities were evaluated using a method developed by Erel. Serum lipid levels were measured using an autoanalyzer (Roche Hitachi Cobas c501).Results: Serum lipid profiles, PON1/ARE activity and HDL levels were similar to those of the control group. No statistical correlation was found between lipid parameters and PON1 or ARE levels in the patient and control groups.Conclusion: According to our results, investigating PON1 and ARE activities may be meaningless whenever migraineurs have no vascular risk factors. On the other hand, studies of longer duration will be required to evaluate the longitudinal relationship between PON1 and ARE activity in the etiopathogenesis of migraine.Keywords: Paraoxonase, arylesterase, high-density lipoprotein, migraine Amaç: Paraoksonaz 1 (PON1) yüksek yoğunluklu lipoprotein (HDL) ile ilişkilidir ve düşük yoğunluklu lipoproteinin (LDL) oksidasyonunu inhibe eder. HDL'nin antioksidan ve antiaterojenik özelliği bu duruma bağlanmaktadır. Vasküler aterosklerotik süreçte tanımlanan enflamasyon, oksidatif stres ve endotelyal disfonksiyon gibi mekanizmalar migren patofizyolojisinde yer almaktadır. Çeşitli çalışmalarda hiperlipidemi migren ilişkisi tanımlanmıştır ancak farklı sonuçlar bildirilmiştir. Biz bu çalışmada migren hastalarında genel lipid profili ve PON1, ARE aktivitesi ile HDL düzeyleri arasındaki ilişkiyi incelemeyi amaçladık. Gereç ve Yöntem:Çalışma grubuna 150 migren hastası alındı. Kontrol grubu yaş ve cinsiyet uyumlu 71 sağlıklı bireyden oluşmaktadır. Her iki gruptaki bireylerde herhangi bir vasküler risk faktörü yoktu. PON1, arilesteraz (ARE) aktiviteleri Erel tarafından geliştirilen yöntem kullanılarak değerlendirilmiştir. Serum lipid düzeyleri otoanalizör (Roche Hitachi Cobas c501) kullanılarak ölçüldü. Abstract Öz 117Original Article / Özgün Araştırma DO I:10.4274/tnd.09216 Turk J Neurol 2017;23:117-121

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The association between migraine, metabolic syndrome, insulin resistance, and obesity in women: Case-control study

Özcan¹,

Özmen

2018

Sisli Etfal

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M igraine headache is a complicated, repetitive headache disorder that is a very pervasive complaint in neurology. The overall prevalence is 5% to 15%, [1, 2] and it is more frequent among females than males. [3] Migraines are thought to be related to various comorbid disorders, such as epilepsy, depression, anxiety, ischemic stroke, Raynaud's phenomenon, iron deficiency anemia, obesity, insulin resistance (IR), and metabolic syndrome. [4-6] However, the relationship between migraines and these comorbid disorders is not yet clear, [7] particularly any association with obesity, IR, or metabolic syndrome. Some researchers have found an association between metabolic syndrome and migraine; [4, 8] however other studies have had different results. [9] Guldiken et al. [4] found that Objectives: The aim of this study was to examine the relationship between migraines and obesity, insulin resistance (IR), and metabolic syndrome in female migraineurs. Methods: A total of 141 female patients who experience migraines and a control group of 141 sex-and age-matched individuals who do not were enrolled in this case-control study. The migraine group was composed of patients from the Gebze Fatih Community Hospital (Kocaeli, Turkey) neurology outpatient service and the control group included hospital staff and friends who volunteered to participate. Descriptive statistics and multivariate logistic regression analyses were performed. Migraine was designated as a dependent variable. Family history of migraine, stroke, metabolic syndrome, cardiac disease, hypertension, hyperlipidemia, and diabetes mellitus; cigarette use; alcohol consumption; and the presence of hypertension, IR, hypertriglyceridemia, low level of high-density lipoprotein (HDL), central obesity, metabolic syndrome; as well as homeostasis model assessment and quantitative insulin sensitivity check index results were selected as independent variables. Results: The mean waist circumference, mean height, mean weight, and central obesity were greater in the control group (p=0.009, 0.004, 0.036, and 0.015, respectively). A multivariate logistic regression model of migraine presence showed that a family history of migraine (odds ratio [OR]: 1.542, 95% confidence interval [CI]: 2.451-8.905; p<0.0001), family history of stroke (OR: 1.043, 95% CI: 1.214-6.633; p=0.016), and no central obesity (OR:-0.705, 95% CI:-0.290-0.843; p=0.010) were statistically significant variables in our study. Conclusion: The results of our study indicated that IR and metabolic syndrome were not associated with migraine in women. There was an inverse relationship between central obesity and migraine. Additional research with larger participant groups should be performed to further explore the complex relationship between migraine, obesity, IR, and metabolic syndrome.

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Systemic Abnormalities in Migraine

Cited by 3 publications

References 21 publications

Metabolic Syndrome and Migraine

Metabolic Syndrome and Migraine

Serum Lipid Profiles, Relationship Between Paraoxonase/Arylesterase Activity and High-density Lipoprotein Levels in Patients with Migraine

The association between migraine, metabolic syndrome, insulin resistance, and obesity in women: Case-control study

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