Systemic administration of racemic baclofen reduces both acquisition and maintenance of alcohol consumption in male and female mice

Bauer, Meredith R.; Hernández, Maribel; Kasten, Chelsea R.; Boehm, Stephen L.

doi:10.1016/j.alcohol.2022.06.003

Cited by 5 publications

(2 citation statements)

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“…Previous research comparing high alcohol preferring lines with other high alcohol consuming mice within experiment have found both similarities and discrepancies between genetic mouse models. For example, systemic administration of NBQX, the same AMPAR antagonist used in this project, reduced binge drinking in C57BL/6J mice but not in selectively bred high alcohol preferring (HAP) mice (Bauer, Garcy, & Boehm, 2020), systemic baclofen reduced binge drinking in both C57BL/6J and HAP mice, but in different ways (Bauer, Hernández, Kasten, & Boehm, 2022), and McCane et al, 2018 found that systemic administration of a catechol-O-methyl transferase inhibitor reduced alcohol drinking in selectively bred alcohol preferring rats (P-rats) but not Wistar rats, even though both rat genotypes consume alcohol. This limitation should be considered when interpreting the findings in this paper.…”

Section: Discussionmentioning

confidence: 97%

“…AUD may be associated with alterations in the balance in behavioral flexibility controlled by the dorsomedial and dorsolateral striatum (DLS). Further, the DLS is necessary for driving binge alcohol drinking in C57BL/6J mice (Bauer, McVey, & Boehm, 2022; Bauer et al, 2022; Haggerty et al, 2022). However, it is unknown whether selectively bred crossed high alcohol preferring mice also rely on the DLS for binge drinking or whether the balance in behavioral control between dorsal striatal subregions has shifted in the mouse model of a family history of AUD.…”

Section: Introductionmentioning

confidence: 99%

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Dorsomedial Striatal Glutamatergic Transmission Inhibits Binge Drinking in Selectively Bred Crossed High Alcohol Preferring Mice

Bauer,

McVey,

Zhang

et al. 2024

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Crossed high alcohol preferring (cHAP) mice have been selectively bred to consume considerable amounts of alcohol resulting in binge drinking. The dorsal striatum (DS) is a brain region involved in action selection where the dorsomedial striatum (DMS) is involved in goal-directed action selection and dorsolateral striatum (DLS) is involved in habitual action selection. Alcohol use disorder (AUD) may involve a disruption in the balance between the DMS and DLS. While the DLS is involved in binge drinking, the reliance on the DMS and DLS in binge drinking has not been investigated in cHAP mice. We have previously demonstrated that glutamatergic activity in the DLS is necessary for binge-like alcohol drinking in C57BL/6J mice, another high drinking mouse. Because of this, we hypothesized that DLS glutamatergic activity would gate binge-like alcohol drinking in cHAP mice. cHAP mice underwent bilateral cannulation into the DMS or DLS and were allowed free-access to 20% alcohol for two-hours each day for 11 days. Mice were microinjected with the AMPA receptor (AMPAR) antagonist, NBQX, into the DMS or DLS immediately prior to alcohol access. AMPAR protein expression was also assessed in a separate group of animals in DS subregions following an 11-day drinking history. We found that intra-DMS (but not intra-DLS) NBQX, alters binge alcohol drinking, with intra-DMS NBQX increasing alcohol consumption. We also found that the ratio of GluA1 to GluA2 differs across DS subregions. Together, these findings suggest that glutamatergic activity in the DMS may serve to limit binge drinking in cHAP mice.

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Section: Discussionmentioning

confidence: 97%