Systemic Administration with Bacteria-Inspired Nanosystems for Targeted Oncolytic Therapy and Antitumor Immunomodulation

Shen, Cheng; Li, Yachao; Zeng, Zenan; Liu, Yiming; Xu, Yini; Deng, Kefurong; Guo, Beiling; Zou, Dongzhe; Liu, Liguo; Liang, Xiaoyu; Xu, Xianghui

doi:10.1021/acsnano.3c10302

ACS Nano

2023

DOI: 10.1021/acsnano.3c10302

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Systemic Administration with Bacteria-Inspired Nanosystems for Targeted Oncolytic Therapy and Antitumor Immunomodulation

Cheng Shen,

Yachao Li,

Zenan Zeng

et al.

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Cited by 5 publications

References 51 publications

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Inherent Tumor Microenvironment‐Reversing Hydrogels: Potentiating Molecular Therapy Efficacy Against Drug‐Resistant Tumors

Liang,

Li,

Guo

et al. 2024

Adv Funct Materials

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The tumor microenvironment is a pivotal driver of tumor progression, highlighting the potential of microenvironment reversal as a promising breakthrough in cancer therapy. However, the current tumor microenvironment reversing capacity through targeted drug delivery remains limited, posing a significant challenge in the biomedical field. In this study, a materials science strategy to achieve an inherently efficient reversal of the solid tumor microenvironment while potentiating molecular therapy efficacy against drug‐resistant tumors is proposed. To construct bioactive hydrogel materials, biocompatible and acid‐reversible nanoclays are utilized as building blocks, and peptide polydendrons are designed as supramolecular cross‐linkers. To drive hydrogel network formation, bioactive hydrogels are capable of reversing tumor acidotic microenvironment, integrating superior mechanical properties, injectability, self‐healing capability, and drug‐loading capacity. Through a drug‐resistant cell line in vitro and a tumor‐bearing mouse model in vivo, the hydrogel materials successfully modulate acidic accumulation resulting from tumor metabolic abnormalities and reverse the acidic microenvironment within the tumor tissue. Remarkably, the tumor microenvironment‐reversing hydrogels effectively suppress tumor cell proliferation, migration, and invasion, while significantly amplifying the antitumor drug efficacy. The bioactive hydrogel materials offer an innovative avenue for reversing the tumor microenvironment, displaying promising prospects for clinical translation and applications.

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Inherent Tumor Microenvironment‐Reversing Hydrogels: Potentiating Molecular Therapy Efficacy Against Drug‐Resistant Tumors

Liang,

Li,

Guo

et al. 2024

Adv Funct Materials

Self Cite

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Physicochemical Cues Steering Spiky Mn/MoOx Nanocarriers to Mimic Oncolytic Virus for Potentiating Cancer Immunotherapy

Zhao,

Zhang

et al. 2024

Adv Funct Materials

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The approval of oncolytic viruses as antigen‐agnostic cancer vaccines provides a paradigm shift for immunotherapy. However, a delicate balance between safety and immunogenicity whether native or engineered oncolytic viruses remains elusive and further compounded by oncolysis‐induced immunosuppression. To address these dilemmas, the de novo design and synthesis of oncolytic viruses‐inspired nanoplatform are proposed by emulating desirable nanostructure and bioactivity for effective cancer immunotherapy. Initially, the influence of MoOx nanoparticles with varying physical morphologies on siRNA transfection are explored, wherein the virus‐inspired MoOx nanoparticles with spiky surfaces (Spi‐MoOx) are well positioned to serve as siRNA vectors to present the highest transfection efficacy. Given the preexisting immune suppression, defect engineering is incorporated into Spi‐MoOx through Mn dopants (Spi‐Mn/MoOx), in an effort to participate in tumor adaptation to hypoxia and maximize the oncolytic potency, while retaining favorable safety profiles. More importantly, the engineered oncolytic viruses hold considerable promise to function as a universal platform that enables any gene to be modulated precisely, allowing the selective activation of various pathways. Collectively, the study offers insights into the biomimetic synthesis and bioactivity of biological system through manipulating the physicochemical cues, while carrying significant implications to propel artificial oncolytic agents from the laboratory to clinical settings.

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Tumor microenvironment-activated polypeptide nanoparticles for oncolytic immunotherapy

Guo,

Huang,

et al. 2025

Biomaterials

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Systemic Administration with Bacteria-Inspired Nanosystems for Targeted Oncolytic Therapy and Antitumor Immunomodulation

Cited by 5 publications

References 51 publications

Inherent Tumor Microenvironment‐Reversing Hydrogels: Potentiating Molecular Therapy Efficacy Against Drug‐Resistant Tumors

Inherent Tumor Microenvironment‐Reversing Hydrogels: Potentiating Molecular Therapy Efficacy Against Drug‐Resistant Tumors

Physicochemical Cues Steering Spiky Mn/MoOx Nanocarriers to Mimic Oncolytic Virus for Potentiating Cancer Immunotherapy

Tumor microenvironment-activated polypeptide nanoparticles for oncolytic immunotherapy

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