2001
DOI: 10.1089/088922201316912790
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Systemic and Intestinal Immune Responses to HIV-2287Infection inMacaca nemestrina

Abstract: Nonhuman primate models of human AIDS have been used successfully to evaluate candidate vaccines and infection intervention therapies. Successes of pathogenicity studies in primate models have been limited because of the varied infection outcomes and characteristic low number of study animals. The acutely pathogenic HIV-2(287)--Macaca nemestrina model has shown promise both in antiviral drug evaluation and in pathogenicity studies. Here we describe virus replication, spread, and host responses during the first… Show more

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Cited by 3 publications
(3 citation statements)
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“…This finding was consistent with an early report by Rosenberg et al, who found that SIV PBj-14 -infected pig-tailed macaques were more susceptible to death resulting from gastrointestinal distress than their rhesus counterparts [ 26 ]. Similarly, other studies have documented persistent infection, CD4 + T cell depletion, and/or development of AIDS-like diseases in pig-tails, but not rhesus, infected with HIV-2 primary isolates [ 27 - 29 ]. Thus, based on their increased susceptibility to HIV infection and to lentivirus-induced disease, compared to rhesus, pig-tailed macaques may be a useful animal model for addressing the diverse responses to HIV-1 infection in humans.…”
Section: Introductionmentioning
confidence: 83%
“…This finding was consistent with an early report by Rosenberg et al, who found that SIV PBj-14 -infected pig-tailed macaques were more susceptible to death resulting from gastrointestinal distress than their rhesus counterparts [ 26 ]. Similarly, other studies have documented persistent infection, CD4 + T cell depletion, and/or development of AIDS-like diseases in pig-tails, but not rhesus, infected with HIV-2 primary isolates [ 27 - 29 ]. Thus, based on their increased susceptibility to HIV infection and to lentivirus-induced disease, compared to rhesus, pig-tailed macaques may be a useful animal model for addressing the diverse responses to HIV-1 infection in humans.…”
Section: Introductionmentioning
confidence: 83%
“…The immunologic and viral characteristics of these three progression groups have been extensively documented. 6,8,17,18 Rapidly progressing animals exhibit a high, sustained viral load, fail to seroconvert to the virus, and usually die within 9 months of infection. 1,7 Animals in the typical progression group exhibit moderate levels of viral load, develop moderate to strong immunity to the virus, and lose up to 50% of CD4 1 T cells early in infection.…”
Section: Characteristics Of the Study Animals With Differential Ratesmentioning
confidence: 99%
“…The 3-week time point was reflective of events including seroconversion and peak viremia. 18,19 The 7-week time point represents the postseroconversion viral set point, at which time characteristics of viral load have been shown to be prognostic of disease course. 7 Over the course of our study, while the viral load levels clearly distinguished the three progression groups, the total lymphocyte populations in the three groups were identical and unchanged.…”
Section: Characteristics Of the Study Animals With Differential Ratesmentioning
confidence: 99%