Systemic and local antibody responses to gastric Campylobacter pyloridis in non-ulcer dyspepsia.

Abstract

SUMMARY Antibody titres to Campylobacter pyloridis in serum and gastric juice were estimated by an enzyme linked immunosorbent assay (ELISA) to whole organisms obtained from bacterial culture in 39 patients with non-ulcer dyspepsia. Whereas 20 of the 21 patients with chronic gastritis had gastric C pyloridis, 17 patients with no C pyloridis had normal histology in the gastric antrum and body. Significantly raised serum IgG and IgA antibody titres to C pyloridis were found in colonised patients with gastritis. Patients with raised IgG antibody to C pyloridis were also shown to have significantly raised titres to other Campylobacter species, suggesting antigenic cross reactivity. Gastric juice antibodies were also studied and IgA titres to C pyloridis were detected in a proportion of patients with gastritis, together with low levels of IgM, but no IgG.

Increased Mucosal Production of Monomeric IgA1 but No IgA1 Protease Activity in Helicobacter pylori Gastritis

“…1 H. pylori-specific IgA and IgG can regularly be detected both systemically [2][3][4] and at the gastric mucosal level 3,4 in infected patients, whereas only some patients with chronic gastritis have IgA antibodies (and low levels of IgM antibodies) in their gastric juice. 3,4 Importantly, despite induction of local immune responses, subsequently treated patients appear to be unprotected against reinfection. 5 Nevertheless, a role for secretory immunity in early H. pylori colonization has been suggested because sucklings are temporarily protected by specific IgA antibodies present in breast milk.…”

Avances en la búsqueda de la vacuna contra Helicobacter pylori

“…[17][18][19] . Al infectar la mucosa gástrica se produce un aumento local en la síntesis y secreción de citoquinas proinflamatorias como las IL (Interleucinas) 1B, 6, 8, 12, 18 y 23, INF-ƴ (Interferón-ƴ) y TNF-α (Factor de Necrosis Tumoral-α) por parte de varias células, como las células dendríticas, células T, monocitos y neutrófilos, entre otras, en respuesta a moléculas y sustancias secretadas por la bacteria y a la interacción directa con ella [20][21][22][23][24][25] .…”

Mucosal IgA & IL-1β in Helicobacter pylori Infection

“…Both local and systemic antibody responses to the Helicobacter infection have been demonstrated that include IgA, IgM, and IgG istotypes [3,5,6]. H. pylori bacteria reside in the mucus layer covering the gastric epithelium.…”