Systemic antibiotic therapy in periodontics

Winkelhoff, A.J. van; Rams, Thomas E.; Slots, Jørgen

doi:10.1111/j.1600-0757.1996.tb00068.x

Cited by 323 publications

(318 citation statements)

References 189 publications

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“…Putative pathogens associated with periodontal disease are susceptible to a variety of antiseptics and antibiotics [2,3]. Methods employed to convey antimicrobial agents into periodontal pockets include rinsing, irrigation, systemic administration and local application using sustained and controlled delivery devices.…”

Section: Original Articlementioning

confidence: 99%

Local Drug Delivery with Tetracycline Fiber : An Alternative to Surgical Periodontal Therapy

Panwar

Gupta²

2009

Medical Journal Armed Forces India

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Background: Scaling and root planing is the basic treatment modality for periodontal disease. Mechanical treatment is limited by physical impediments and biochemical considerations. Antimicrobial agents may be used as an adjunct to overcome limitations of mechanical therapy. Methods: A case-control study was carried out on 30 patients suffering from chronic periodontitis. In Group A only scaling and root planing was carried out whereas in Group B tetracycline fibers were used along with scaling and root planing. Result: Tetracycline fibers as an adjunct to scaling and root planing was found to be more effective in reducing inflammation. The number of sites with bleeding on probing were 12 in Group A as compared to four in Group B after 30 days. The mean decrease in probing depth was more in Group B than Group A after 30 and 90 days. General linear model showed that decrease in probing depth was statistically significant with both mechanical therapy as well as adjunctive use of tetracycline fibers. Conclusion: Local drug delivery with tetracycline fiber is an effective and simple non surgical method to improve periodontal health which can be practiced even by a general dental practitioner. MJAFI 2009; 65 : 244-246

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Section: Original Articlementioning

confidence: 99%

Local Drug Delivery with Tetracycline Fiber : An Alternative to Surgical Periodontal Therapy

Panwar

Gupta²

2009

Medical Journal Armed Forces India

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“…Systemic antibiotics therapy for periodontal treatment usually involves monotherapy based on the β-lactams, including amoxicillin with or without clavulanic acid, metronidazole, tetracyclines (tetracycline, doxycycline, minocycline), clindamycin and ciprofloxacin (5).…”

Section: Systemic Antibioticsmentioning

confidence: 99%

Antimicrobials in treatment of periodontal disease -A review

Paddmanabhan¹

2013

IOSR-JDMS

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“…The primary goal of currently applied therapeutics for periodontitis is reducing the subgingival bacterial load via instrumental debridement with surgical or non-surgical approaches (6,7). However, entire removal of the resulting biofilm when bacterially affected root surfaces are embedded in soft tissues or located in anatomically inaccessible areas is almost impossible; antibiotics or antiseptics are often administered as adjuvant treatments (8). Therefore, some periodontitis cases can be unresponsive to a conventional therapy, calling for the development of novel therapeutic regimens for periodontitis.…”

Section: Introductionmentioning

confidence: 99%

Effect of local bone marrow stromal cell administration on ligature-induced periodontitis in mice

et al. 2017

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Bone marrow-derived multipotent stromal cells (BMSCs) have potent antiinflammatory effects. This study aimed to investigate the antiinflammatory potential of BMSCs using a mouse model of ligatureinduced periodontitis. BMSCs were isolated from the femurs and tibiae of mice. Periodontitis was induced by placing a ligature around the right maxillary second molar. After 3 days, the mice were administered BMSC in the gingiva of the mesial interdental papilla around the ligatured molar. The ligatured and non-ligatured mice that were not administered BMSC served as controls. Differences in inflammatory infiltration and bone resorption around the roots of the second molar were assessed and were subsequently quantified using microcomputed tomography (micro-CT), histological analysis, and tartrate-resistant acid phosphatase (TRAP) staining. Micro-CT revealed that alveolar bone loss around the ligatured molars increased in a time-dependent manner; however, the effect was significantly less in BMSC-treated mice compared with ligatured control mice. Tissue histopathology revealed that BMSC administration mitigated inflammatory infiltration in ligatured BMSC mice. In addition, the number of TRAP-positive osteoclasts was markedly elevated in ligatured control mice compared with those in BMSC-treated mice. These findings indicate that local BMSC administration can mitigate inflammation and alveolar bone resorption, suggesting that administering BMSC leads to new therapeutics for periodontitis.

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Systemic antibiotic therapy in periodontics

Cited by 323 publications

References 189 publications

Local Drug Delivery with Tetracycline Fiber : An Alternative to Surgical Periodontal Therapy

Local Drug Delivery with Tetracycline Fiber : An Alternative to Surgical Periodontal Therapy

Antimicrobials in treatment of periodontal disease -A review

Effect of local bone marrow stromal cell administration on ligature-induced periodontitis in mice

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