Systemic Antioxidants and Lung Function in Asthmatics during High Ozone Season: A Closer Look at Albumin, Glutathione, and Associations with Lung Function

Khatri, Sumita; Peabody, Jeannie; Burwell, Leandrea; Harris, Frank L.; Brown, L. Neville

doi:10.1111/cts.12152

Cited by 14 publications

(12 citation statements)

References 21 publications

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“…Therefore, we hypothesized that albumin is an indicator of inflammatory process, and for this reason it is related with poor pulmonary function 20 . Khatri et al 13 showed that plasma albumin levels directly correlated with FEV 1 % predicted among asthmatic subjects (R=0.378; p=0.010).…”

Section: Discussionmentioning

confidence: 99%

“…In a previous study, Khatri et al 13 observed that albumin was significantly correlated with lung function and asthma quality of life scores. There is only one study that demonstrated albumin as a predictor of lung function in CF subjects 14 …”

Section: Introductionmentioning

confidence: 94%

“…Lungs have multiple layers of defense against persistent oxidant stress, and albumin is an important non-enzymatic antioxidant of interest in this disease. In addition, it is the most abundant multifunctional plasma protein and it has been noted to be a substantial contributor to systemic antioxidant capability, as well as having anti-inflammatory functions 13 …”

Section: Introductionmentioning

confidence: 99%

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Body Mass Index and Albumin Levels Are Associated With Pulmonary Function Parameters in Pediatric Subjects With Cystic Fibrosis

Simon

Forte

Maróstica

2019

Rev. paul. pediatr.

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Objective: To evaluate the association of body mass index (BMI) and albumin with pulmonary function in cystic fibrosis (CF) pediatric subjects.Methods: This is a cross-sectional study with clinically stable CF’s subjects. Clinical (pulmonary function) and nutritional evaluation (body mass index and albumin) were performed. Univariate analysis was performed using simple linear correlations. Regression analysis was performed using an exit level of p<0.05.Results: Seventy-eight CF’s subjects (mean age 12.8±3.8 years) with mean albumin 4.2±0.4 mg/dL, predicted forced expiratory volume in 1 second (FEV1%) 80.8±22.6 and BMI median percentile 51.2 (1.3-97.7). In the multiple regression models, albumin, age and BMI percentile were associated with pulmonary function. Subjects with lower than 25 BMI percentile had 12.2% lower FEV1%. An albumin increase of 0.1 mg was associated with 2.7% increase in predicted FEV1%, and one year increase in age was associated with reduction in 1.2% of predicted FEV1%.Conclusions: BMI percentile, albumin and age were independently associated with predicted FEV1% in a tertiary referral hospital.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Body Mass Index and Albumin Levels Are Associated With Pulmonary Function Parameters in Pediatric Subjects With Cystic Fibrosis

Simon

Forte

Maróstica

2019

Rev. paul. pediatr.

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“…Air pollution has been associated with poor health outcomes and continues to be a risk factor for respiratory health. Epidemiologic, panel, and longitudinal cohort studies in adults and children have demonstrated increased frequency of asthma symptoms, new onset of asthma, worsening of lung function, reduced pace of lung development, and increased airway inflammation, including from oxidant stress [ 1 – 4 ]. During times of poor air quality with higher levels of air pollution, the deleterious effects are evident by acute and chronic symptomatology and development of chronic diseases, such as allergic rhinitis and asthma [ 5 – 13 ].…”

Section: Introductionmentioning

confidence: 99%

Associations of Air Pollution and Pediatric Asthma in Cleveland, Ohio

Khatri

Newman

Hammel

et al. 2021

The Scientific World Journal

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Air pollution has been associated with poor health outcomes and continues to be a risk factor for respiratory health in children. While higher particulate matter (PM) levels are associated with increased frequency of symptoms, lower lung function, and increase airway inflammation from asthma, the precise composition of the particles that are more highly associated with poor health outcomes or healthcare utilization are not fully elucidated. PM is measured quantifiably by current air pollution monitoring systems. To better determine sources of PM and speciation of such sources, a particulate matter (PM) source apportionment study, the Cleveland Multiple Air Pollutant Study (CMAPS), was conducted in Cleveland, Ohio, in 2009–2010, which allowed more refined assessment of associations with health outcomes. This article presents an evaluation of short-term (daily) and long-term associations between motor vehicle and industrial air pollution components and pediatric asthma emergency department (ED) visits by evaluating two sets of air quality data with healthcare utilization for pediatric asthma. Exposure estimates were developed using land use regression models for long-term exposures for nitrogen dioxide (NO2) and coarse (i.e., with aerodynamic diameters between 2.5 and 10 μm) particulate matter (PM) and the US EPA Positive Matrix Factorization receptor model for short-term exposures to fine (<2.5 μm) and coarse PM components. Exposure metrics from these two approaches were used in asthma ED visit prevalence and time series analyses to investigate seasonal-averaged short- and long-term impacts of both motor vehicles and industry emissions. Increased pediatric asthma ED visits were found for LUR coarse PM and NO2 estimates, which were primarily contributed by motor vehicles. Consistent, statistically significant associations with pediatric asthma visits were observed, with short-term exposures to components of fine and coarse iron PM associated with steel production. Our study is the first to combine spatial and time series analysis of ED visits for asthma using the same periods and shows that PM related to motor vehicle emissions and iron/steel production are associated with increased pediatric asthma visits.

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“…Under pathological conditions, the highly expressed VEGF binding to its receptor can cause structural changes in the extravascular matrix and interstitial oedema, cause airway remodelling and aggravate asthma symptoms (Zhao et al, 2018). (Khatri et al (2014). found that albumin significantly correlated with lung function (%FEV(1)) and asthma quality of life scores.…”

mentioning

confidence: 99%

Xuefu Zhuyu decoction improves asthma‐induced asthenozoospermia based on network pharmacology and in vivo experiment

et al. 2021

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Asthma is a heterogeneous disease, composed of different phenotypes, which are driven by different mechanisms and pathways.The global prevalence of asthma ranges from 1% to 18%, and it is estimated that there are about 300 million asthma patients in the world (Eder et al., 2006). In individuals with severe asthma, the activation of apoptotic pathways caused by hypoxia and severe reactions has attracted widespread attention. At the same time, in the world, 8%-12% of couples of childbearing age are affected by infertility (Vander Borght and Wyns, 2018). Among them, male infertility, caused by male factors, accounts for about 50% of cases.Asthenozoospermia is an important cause of male infertility and its aetiology is very complicated. Andrological diseases usually accompany other system diseases (Shahrokhi et al., 2020). Some literature studies have shown that under inflammatory conditions, testicular temperature rises, testicular morphology changes, intercellular spaces increase, seminiferous epithelia thins out,

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Systemic Antioxidants and Lung Function in Asthmatics during High Ozone Season: A Closer Look at Albumin, Glutathione, and Associations with Lung Function

Cited by 14 publications

References 21 publications

Body Mass Index and Albumin Levels Are Associated With Pulmonary Function Parameters in Pediatric Subjects With Cystic Fibrosis

Body Mass Index and Albumin Levels Are Associated With Pulmonary Function Parameters in Pediatric Subjects With Cystic Fibrosis

Associations of Air Pollution and Pediatric Asthma in Cleveland, Ohio

Xuefu Zhuyu decoction improves asthma‐induced asthenozoospermia based on network pharmacology and in vivo experiment

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