Xuefu Zhuyu decoction improves asthma‐induced asthenozoospermia based on network pharmacology and in vivo experiment

Deng, Sheng; Gong, Xuefeng; Long, Zhongwen; Bao, Binghao; Meng, Fanchao; Feng, Junlong; Kuang, Hao; Li, Haisong; Wang, Bin; Wang, Jisheng

doi:10.1111/and.14198

Cited by 3 publications

(4 citation statements)

References 42 publications

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“…In recent years, there has been an increasing number of clinical studies on TCM , 76 , 77 , 78 and randomized controlled trials 79 , 80 , 81 have also been carried out one after another, which achieved certain effects and were increasingly recognized by Western Medicine. Therefore, the TCM decoction plays an important role in improving the number of sperm.…”

Section: Resultsmentioning

confidence: 99%

Treatment progress of cryptozoospermia with Western Medicine and traditional Chinese medicine: A literature review

Liu

Luo²,

Chen

et al. 2022

Health Science Reports

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Background and Aims Cryptozoospermia is an extreme oligozoospermia with an unsatisfactory treatment effect, with an incidence rate of approximately 8.73% in male infertility, whose effective solution has become the call of the times. Western Medicine has achieved certain effects through drugs, surgery, and assisted reproductive therapy, but this is still not ideal. Traditional Chinese medicine ( TCM ) has made many achievements in other disciplines; however, there is still a lack of evidence‐based medical evidence to improve sperm production. Methods The relevant literatures from the China National Knowledge Internet ( CNKI ) and PubMed in the past 10 years were collected in this article, of which the mechanisms, advantages, or current controversies of various treatment methods of Western Medicine and TCM were analyzed, to find new treatment methods and research directions. Results With the development of modern science and technology, medical treatments for cryptozoospermia have become increasingly abundant; however, there is still no universally recognized unified and effective guiding plan. Although TCM has not been fully verified by evidence‐based medicine, most TCM combined with Western Medicine can achieve unexpected results. Conclusion The combination of TCM and Western Medicine may become a bane for cryptozoospermia and bring good news to infertile men worldwide.

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Section: Resultsmentioning

confidence: 99%

Treatment progress of cryptozoospermia with Western Medicine and traditional Chinese medicine: A literature review

Liu

Luo²,

Chen

et al. 2022

Health Science Reports

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“…Our finding on the association between asthma and abnormal spermatozoa risk is consistent with previous studies. Recently, Multiple mouse model studies consistently indicate an association between asthma and spermatozoa quality, primarily characterized by significantly lower spermatozoa concentration and motility in the asthma mouse group compared to the control group ( Xu et al, 2016 ; Deng et al, 2021 ; Wang et al, 2021 ; Feng et al, 2022 ). Xu et al (2016) propose that asthma could activate the mitochondrial apoptosis signaling pathway in the mouse testis, thereby impacting spermatozoa quality.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, Feng et al (2022) argue that asthma can modulate the HIF-1 signaling pathway, resulting in increased expression of IL6, Stat3, HIF-1α protein, and mRNA, ultimately leading to spermatozoa apoptosis. Additionally, Deng et al (2021) suggest that asthma can induce the production of abnormal spermatozoa by upregulating the expression of IL-6, vascular endothelial growth factor A, and mRNA while inhibiting albumin expression levels. In addition, only one cross-sectional study in humans found a potential association between self-reported asthma patients and reduced testicular function, primarily manifested by decreased spermatozoa concentration and total spermatozoa count.…”

Section: Discussionmentioning

confidence: 99%

“…It is characterized by a range of respiratory symptoms and airflow limitation to varied degrees, which can be generated by a range of airway inflammation and bronchospasm ( Papi et al, 2018 ). As illustrated in animal models, male mice with asthma were related to abnormal spermatozoa and testicular structure ( Xu et al, 2016 ; Deng et al, 2021 ; Wang et al, 2021 ; Feng et al, 2022 ). Moreover, a cross-sectional study in humans showed that men with asthma had lower spermatozoa concentration and total spermatozoa count compared with non-asthmatic men ( Pedersen et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

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Genetically predicted asthma and the risk of abnormal spermatozoa

Li,

Teng,

Han

et al. 2024

Front. Genet.

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BackgroundSeveral previous animal and human studies have found a strong association between asthma and spermatozoa quality, but whether these associations are causal or due to bias remains to be elucidated.MethodsWe performed a two-sample Mendelian randomization (MR) analysis to assess the causal effect of genetically predicted asthma on the risk of abnormal spermatozoa. Asthma, childhood-onset asthma (COA), and adult-onset asthma (AOA) (sample sizes ranging from 327,670 to 408,442) were included as the exposures. Genetic information for abnormal spermatozoa was obtained from a genome-wide association study (GWAS) comprising 209,921 participants. In univariable MR (UVMR) analysis, the inverse variance weighted (IVW) method was conducted as the primary method, with the MR Egger and weighted median used as supplementary methods for causal inference. Sensitivity analyses, including the Cochran Q test, Egger intercept test, MR-PRESSO, and leave-one-out analysis, were performed to verify the robustness of the MR results. Multivariable MR (MVMR) was conducted to evaluate the direct causal effects of asthma on abnormal spermatozoa risk.ResultsUVMR detected causal associations between genetically predicted asthma and an increased risk of abnormal spermatozoa (OR: 1.270, 95% CI: 1.045–1.545, p = 0.017). Moreover, we found that AOA (OR: 1.46, 95% CI: 1.051, 2.018, p = 0.024) has positive causal effects on the risk of abnormal spermatozoa rather than COA (p = 0.558). Sensitivity analysis found little evidence of bias in the current study (p > 0.05). MVMR further confirmed that asthma directly affected the risk of abnormal spermatozoa.ConclusionOur MR study suggested that genetically predicted asthma could be associated with an increased risk of abnormal spermatozoa, and similar results were obtained in AOA. Further studies are warranted to explain the underlying mechanisms of this association and may provide new avenues for prevention and treatment.

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Study on the Mechanism of Dachaihu Decoction in the Treatment of Acute Pancreatitis Based on Artificial Intelligence Combined with in vivo Experiments

Zhang

et al. 2023

CCHTS

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Background and Aim: To explore the possible mechanism of Dachaihu Decoction (DCHD) in the treatment of AP, and use in vivo experiments to verify. background: none Methods: The targets and active ingredients of DCHD in the treatment of AP were obtained through network pharmacology, and the preliminary verification was carried out by molecular docking. Caerulein was used to develop the AP rat model. H&E staining was performed to observe variations in pancreatic tissue. Western blot and RT-qPCR were conducted to evaluate the associated proteins and mRNA. objective: none Results: The network pharmacology and molecular docking results showed that the key targets (EGFR, TNF, SRC, VEGFA and CTNNB1) and key active components (beta-sitosterol, stigmasterol, baicalein, quercetin, and kaempferol) of DCHD in the treatment of AP had good binding. H&E staining revealed that rat pancreatic tissues considerably damaged post caerulein intervention, and it has also been suggested that DCHD ameliorates damage to pancreatic tissue. Simultaneously, EGFR, TNF, SRC, VEGFA protein, and mRNA expression levels were increased in the model group compared to the blank group (P < 0.01), whereas CTNNB1 expression was found to be decreased in the model group (P < 0.01). Compared with the model group, the protein expression levels of EGFR, TNF, SRC, and VEGFA in the treatment group were down-regulated (P < 0.01), and CTNNB1 was up-regulated (P < 0.05). Conclusion: DCHD protects pancreatic tissues and improves symptoms in AP rats by upregulating CTNNB1 protein and mRNA while inhibiting EGFR, TNF, SRC, and VEGFA protein and mRNA expression. conclusion: DCHD protects pancreatic tissues and improves symptoms in AP rats by upregulating CTNNB1 protein and mRNA while inhibiting EGFR, TNF, SRC, and VEGFA protein and mRNA expression. other: none

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Xuefu Zhuyu decoction improves asthma‐induced asthenozoospermia based on network pharmacology and in vivo experiment

Cited by 3 publications

References 42 publications

Treatment progress of cryptozoospermia with Western Medicine and traditional Chinese medicine: A literature review

Treatment progress of cryptozoospermia with Western Medicine and traditional Chinese medicine: A literature review

Genetically predicted asthma and the risk of abnormal spermatozoa

Study on the Mechanism of Dachaihu Decoction in the Treatment of Acute Pancreatitis Based on Artificial Intelligence Combined with in vivo Experiments

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