Systemic contact dermatitis

Abstract

Systemic contact dermatitis is an inflammatory skin disease that may occur in persons with contact allergy when they are exposed to the hapten orally, transcutaneously, per rectum, intravesically, intravenously, or by inhalation. The most common causes of systemic contact dermatitis are drugs used both topically and systemically. Other causes are ubiquitously occurring haptens, such as the metals nickel, cobalt, gold, and chromate, and aromatic substances such as spices. Avoidance of the offending hapten is the most obvious treatment. For some haptens, such as nickel, diet treatment may be effective. Chelation therapy with disulfiram is another therapeutic option in nickel-allergic patients with systemic contact dermatitis. Hyposensitization therapy has been attempted with some success in systemic contact dermatitis caused by nickel and Parthenium hysterophorus.

Systemic allergic dermatitis caused by diltiazem

“…In this particular case, the patient had been exposed to diltiazem in a gel used to treat anal fissures, highlighting the high degree of absorption in this area. The patient developed a generalized maculopapular rash, which is one of many clinical manifestations of a systemic allergic reaction (5).…”

Experimental inhalation of fragrance allergens in predisposed subjects: effects on skin and airways

“…Three routes of systemic availability can be considered: dermal exposure and permeation, oral ingestion and inhalation. 3 Certainly it is difficult to prove a causal role for inhalation in the presence of aerogenic dermal exposure. 4 We therefore took an experimental approach to study whether inhalation of allergenic fragrances, while excluding dermal exposure, would provoke systemic (haematogenic) contact dermatitis in sensitized patients.…”

Asteraceae species as potential environmental factors of allergy

“…Systemic contact (allergic) dermatitis (SCD) is an inflammatory skin disease and occurs in sensitized person after oral, inhalation, intravesical, intravenous, or transcutaneous exposure to the haptens (Nicolas et al 2008; Veien 2011). Systemic reactions are induced by both humoral and cell-mediated mechanism including T cells and cytokine secretion (Paulsen 2017).…”