Systemic Correlates of Angiographic Coronary Artery Disease

Abstract

Coronary angiography allows a direct evaluation of coronary anatomy. The aim of the present investigation was to search for correlations between the magnitude of coronary artery disease, as assessed by angiography, and a number of systemic parameters. A group of 116 patients (80 male, 36 female) with coronary heart disease diagnosed by angiography, aged 62.0±10.5 years, was the subject of an observational study. Correlation and linear regression analysis using coronary artery disease burden (CADB - sum of the percentage of the luminal stenosis encountered in all the lesions of the coronary arterial trees) as dependent variable, and age, sex, plasma calcium, phosphorus, magnesium, glucose, HDL cholesterol, LDL cholesterol, triglycerides, uric acid, estimated glomerular filtration rate and body mass index as independent variables, were carried out. Significant correlation values versus CADB were seen with age (r 0.19, p 0.04), uric acid (r 0.18, p 0.048) and fasting plasma glucose (r 0.33, p<0.001). Linear regression analysis, yielding a global significance level of 0.002, showed a significant value for glucose (p 0.018) and for sex (0.008). In conclusion, among several systemic parameters studied, plasma glucose was found to be correlated to coronary artery atherosclerosis lesions.

Association of Cardiovascular Risk Factors and Coronary Artery Lesion Among Coronary Artery Disease Patients

“…This discrepancy may be due to the limited size of the study population and is mono-centered. However, some studies have shown a strong association of high LDL and low HDL in severity of lesion though, 12,14 normoglycemic individuals had no differences between with CAD and without CAD. 18 Smoking is considered to be one of the major risk factors in CAD 22,23 and the present study has also revealed the significant relation of smoking with coronary stenosis (OR 4.10; CI 1.45 -11.61, p <0.01), which is also supported from previous studies.…”

“…In the present study, the greater number of coronary artery diseases is associated with the advancing age (80% ) and male (60%, OR 2.47; CI 0.94 -6.48, p <0.05) population is found to have higher association. On other hand, as diabetes mellitus, hypertension, dyslipidemia and smoking are considered to be the cardiovascular risk factors, [10][11][12][13] the current study has analyzed those cardiovascular risk factorsto see the association with significant coronary artery stenosis. Our study shows the significant association (OR 3.32, CI 1.12 -9.84, p <0.05) between diabetes mellitus and coronary artery stenosis.…”

“…In agreement with our findings, other studies have also shown that diabetes mellitus is strong predictor of complex and multiple coronary lesions. 11,12,14 In addition, glycemic control plays the pivotal role in the presence and extents of CAD in diabetic and other high CVD risk groups. 15 Hypertension is one of the major risk factors and the prevalence of hypertension is 28.9% among adult population of Dhulikhel.…”

“…10 Diabetes is significantly correlated with multi-vessel, multi-lesion, extensive disease of coronary arteries. 11,12 This study aims to analyze the associations of established cardiovascular risk factors with coronary artery stenosis.…”

Troponin I, but not BNP, is Associated with Phosphorus, Calcium and Vitamin D in Stable Coronary Artery Disease

“…The research protocol (including the informed consent forms) was evaluated and approved by an independent ethics committee (Comissão de Ética do Centro de Saúde São João, Porto, Portugal), as previously reported [11]. All participants provided a written informed consent, a consent procedure approved by the ethics committee.…”