Systemic diseases and oral health

Ramesh, Shilpa; Neelakantan, Prasanna

doi:10.1016/j.injms.2015.02.003

Cited by 3 publications

(3 citation statements)

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“…Epigenetics is the study of mitotically and meiotically heritable changes in gene expression that are not dependent on DNA sequence, and the epigenome is the overall epigenetic state of an organism [ 28 , 29 ]. Epigenetics is on a continual rise for explaining the particular workings through which certain environmental factors were acting intermediately, having an effect on the gene expression without any alterations on the underlying genetic sequences [ 30 ].…”

Section: Epigeneticsmentioning

confidence: 99%

“…Epigenetics is on a continual rise for explaining the particular workings through which certain environmental factors were acting intermediately, having an effect on the gene expression without any alterations on the underlying genetic sequences [ 30 ]. Epigenetics, a term contrived by Conrad H. Waddington in 1942, was meant to bridge the gaps between genetics, growth, and differentiation, encompassing the “causal mechanisms” through which genes resulted in many and differing phenotypes [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. Epigenetic mechanisms and modifications, defined as apparent DNA alterations that are heritable, entail environmental factors’ effect on modifying the gene expression without any change on the underlying DNA sequence [ 33 ].…”

Section: Epigeneticsmentioning

confidence: 99%

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Emerging Role of Epigenetics in Explaining Relationship of Periodontitis and Cardiovascular Diseases

et al. 2021

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Cardiovascular diseases such as ischemic heart diseases or stroke are among the leading cause of deaths globally, and evidence suggests that these diseases are modulated by a multifactorial and complex interplay of genetic, environmental, and lifestyle factors. Genetic predisposition and chronic exposure to modifiable risk factors have been explored to be involved in the pathophysiology of CVD. Environmental factors contribute to an individual’s propensity to develop major cardiovascular risk factors through epigenetic modifications of DNA and histones via miRNA regulation of protein translation that are types of epigenetic mechanisms and participate in disease development. Periodontal disease (PD) is one of the most common oral diseases in humans that is characterized by low-grade inflammation and has been shown to increase the risk of CVDs. Risk factors involved in PD and CVD are determined both genetically and behaviorally. Periodontal diseases such as chronic inflammation promote DNA methylation. Epigenetic modifications involved in the initiation and progression of atherosclerosis play an essential role in plaque development and vulnerability. Epigenetics has opened a new world to understand and manage human diseases, including CVDs and periodontal diseases. Genetic medicine has started a new era of epigenetics to overcome human diseases with various new methodology. Epigenetic profiling may aid in better diagnosis and stratification of patients showing potential predisposed states for disease. A better understanding of the exact regulatory mechanisms of epigenetic pathways driving inflammation is slowly emerging and will aid in developing novel tools for the treatment of disease.

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Section: Epigeneticsmentioning

confidence: 99%

Section: Epigeneticsmentioning

confidence: 99%

Emerging Role of Epigenetics in Explaining Relationship of Periodontitis and Cardiovascular Diseases

et al. 2021

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“…These oral manifestations can be an early indicator for the disease. Moreover, uncontrolled systemic condition can compromise oral health and quality of life 1‐4 …”

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confidence: 99%

Awareness of systemic diseases effect on oral health among Egyptian dentists: A briefing report

Moussa

Zahran

Moneim

et al. 2020

Special Care in Dentistry

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To the Editor, Knowledge about systemic diseases is important to dentists in many aspects. One of these aspects is oral manifestations caused by systemic diseases. These oral manifestations can be an early indicator for the disease. Moreover, uncontrolled systemic condition can compromise oral health and quality of life. 1-4 Assessing awareness, knowledge, and behavior of dentists regularly is crucial to recognize their level of efficiency. Previous studies in Europe, the United States, and some Arabic countries have assessed knowledge and behavior of dental health care providers regarding oralsystemic health connections. 5-9 Nevertheless, we noticed scarcity in literature concerning assessment of the knowledge and behavior in relevance to oral manifestations of systemic diseases. As far as we know, no previous study has assessed Egyptian dentists' knowledge or behavior concerning oral-systemic health relationship. The current survey is the first to investigate the awareness of the effect of systemic diseases on oral health among a cohort of Egyptian dentists.

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Functional biomedical materials derived from proteins in the acquired salivary pellicle

et al. 2021

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Systemic diseases and oral health

Cited by 3 publications

References 50 publications

Emerging Role of Epigenetics in Explaining Relationship of Periodontitis and Cardiovascular Diseases

Emerging Role of Epigenetics in Explaining Relationship of Periodontitis and Cardiovascular Diseases

Awareness of systemic diseases effect on oral health among Egyptian dentists: A briefing report

Functional biomedical materials derived from proteins in the acquired salivary pellicle

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