Systemic immune-inflammation index and incident cardiovascular diseases among middle-aged and elderly Chinese adults: The Dongfeng-Tongji cohort study

Xu, Man; Chen, Ruoling; Liu, Li; Liu, Xuezhen; Hou, Jian; Liao, Jiaqiang; Zhang, Ping; Huang, Jiao; Li, Lu; Chen, Long; Fan, Mengran; Chen, Xiuyi; Zhu, Xiaofan; Liu, Bing; Hu, Ping

doi:10.1016/j.atherosclerosis.2021.02.012

Cited by 114 publications

(97 citation statements)

References 52 publications

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“…First, optimal cut-off values for defining high SII scores in isolated TV surgery have not yet been established. In our study, the cut-off value for the high SII was arbitrarily determined using ROC, in accordance with previous studies [ 16 , 17 ]. Therefore, it is possible that other SII cut-off values may be more suitable for defining high SII scores.…”

Section: Discussionmentioning

confidence: 91%

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Systemic Immune-Inflammation Index Predicted Short-Term Outcomes in Patients Undergoing Isolated Tricuspid Valve Surgery

Yoon

Jung

Ahn

et al. 2021

JCM

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Systemic immune-inflammation index (SII, platelet × neutrophil/lymphocyte ratio) has recently been identified as an inflammatory marker. We aimed to evaluate the prognostic implications of preoperative SII in patients undergoing isolated tricuspid valve (TV) surgery. In total, 213 patients who underwent isolated TV surgery between January 2000 and December 2018 were enrolled. They were divided into two groups, as follows: low SII (<455.6 × 109/L), and high SII (≥455.6 × 109/L). The correlation between SII and clinical outcomes was analyzed via the Cox regression and the Kaplan–Meier analyses. The primary outcomes considered were all-cause mortality and major postoperative complications within a 30-day period after isolated TV surgery, including major adverse cardiovascular or cerebrovascular events, pulmonary and renal complications, stroke, sepsis, multi-organ failure, wound, and gastrointestinal complications. In total, 82 (38.5%) patients experienced postoperative complications. Multivariable analyses revealed that high preoperative SII values were independently associated with the major 30-day postoperative complications (hazard ratio 3.58, 95% confidence interval 1.62–7.95, p = 0.001). Additionally, Kaplan–Meier analysis revealed that the probability of undergoing major 30-day postoperative complications was significantly elevated in patients with high versus low SII values (p < 0.001). These results indicate that SII, a readily available parameter, is significantly associated with poor outcomes in patients undergoing isolated TV surgery.

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Section: Discussionmentioning

confidence: 91%

“…The SII cut-off value (455.6 × 109/L) was defined by analyzing receiver operating characteristic (ROC) curves of patients using the Youden index method with and without an endpoint of major 30-day postoperative complications. The method used to determine this cut-off was based on previous reports [ 16 , 17 ].…”

Section: Methodsmentioning

confidence: 99%

Systemic Immune-Inflammation Index Predicted Short-Term Outcomes in Patients Undergoing Isolated Tricuspid Valve Surgery

Yoon

Jung

Ahn

et al. 2021

JCM

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“…A number of studies have shown that SII is associated with poor clinical outcomes of various cardiovascular diseases, including acute coronary syndrome, ST segment elevation and non-ST segment elevation myocardial infarction. Studies have shown that a higher SII is independently associated with future risk of cardiac death, non-fatal myocardial infarction, non-fatal stroke or hospitalization due to HF in patients with coronary artery disease (CAD), and it has a better predictive effect on major cardiovascular events after percutaneous coronary intervention ( 9 , 10 ). SII can also predict the severity of coronary artery stenosis ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

“…SII has been proven to be a powerful prognostic indicator of many types of cancer, and it is a useful prognostic index ( 8 ). In several studies, SII was found to be a prognostic marker of coronary heart disease ( 9 , 10 ). However, the prognostic value of SII in PPCM patients has not been proposed before.…”

Section: Introductionmentioning

confidence: 99%

Value of the Systemic Immune-Inflammatory Index (SII) in Predicting the Prognosis of Patients With Peripartum Cardiomyopathy

Zhang

Liu

et al. 2022

Front. Cardiovasc. Med.

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BackgroundPeripartum cardiomyopathy (PPCM) is a potentially life-threatening complication of pregnancy. The identification of early prognostic markers in patients diagnosed with PPCM is very important. The systemic immune-inflammation index (SII) is a new inflammatory biomarker, and the aim of this study was to evaluate the prognostic value of SII in patients with PPCM.MethodsA total of 61 patients with PPCM who were admitted in our hospital from 2015 to 2020 were retrospectively analyzed in this study. The follow-up period of all patients was at least 6 months after diagnosis. Recovery of left ventricular (LV) systolic function was defined as the presence of left ventricular ejection fraction > 45%. The second endpoint was defined as composite adverse cardiac events, including cardiac death or hospitalization due to worsening heart failure. Univariate and multivariate logistic regression analysis were used to determine the independent predictors of non-recovery of LV systolic function. The receiver operating characteristic (ROC) curve analysis was used to establish a cut-off level of SII value to predict persistent LV systolic dysfunction.ResultsThe follow-up duration was 40.5 ± 16.3 months. Among the 61 patients, 43 patients showed left ventricular recovery and 18 patients did not at the last follow-up visit. The baseline SII levels were significantly higher in the non-recovery group (P < 0.05). Multivariate logistic regression showed that the SII and left ventricular end-diastolic dimension (LVEDD) were independent predictors of persistent LV systolic dysfunction (OR: 1.177, 95% CI: 1.038–1.335, P = 0.011 and OR: 1.148, 95% CI: 1.011–1.304, P = 0.033, respectively). A SII value of 876 was the best cut-off value (the area under the curve was 0.791, 95% CI: 0.667–0.915, P < 0.05), and the sensitivity and specificity were 73 and 71%, respectively.ConclusionsThe SII and LVEDD are independent prognostic factors for persistent LV systolic dysfunction in patients with PPCM. The SII may be a useful tool for identifying high-risk PPCM patients.

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“…With the improvement of human living standards, great changes have taken place in diets, which have brought about many adverse effects on human health. Cardiovascular and cerebrovascular diseases continue to threaten the lives of humans, especially those of middle-aged adults and the elderly (1). Most cardiovascular and cerebrovascular diseases show no obvious symptoms before onset, and their onset is usually sudden and serious.…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus plantarum HFY05 Attenuates Carrageenan-Induced Thrombosis in Mice by Regulating NF-κB Pathway-Associated Inflammatory Responses

Zeng

Tan

et al. 2022

Front. Nutr.

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In this study, a carrageenan-induced thrombus model was established in mice to observe the ability of Lactobacillus plantarum KFY05 (LP-KFY05) to inhibit thrombosis through an NF-κB-associated pathway. Biochemical analysis, microscopical observations, quantitative polymerase chain reactions (qPCR) and western blot analysis were used to examine relevant serum and tissue indexes, and the composition of intestinal microorganisms was determined by examining the abundance of microorganisms in feces. The results showed that LP-KFY05 could markedly reduce the degree of black tail in thrombotic mice; increase the activated partial thromboplastin time (APTT); and decrease the thrombin time (TT), fibrinogen (FIB) level, and prothrombin time (PT). LP-KFY05 could also reduce tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β) levels in sera and renal tissues of thrombotic mice. Hematoxylin and eosin staining showed that LP-KFY05 could alleviate renal tissue lesions and tail vein thrombosis. qPCR results showed that LP-KFY05 could down-regulate nuclear factor kappa-B (NF-κB) p65, IL-6, TNF-α, and interferon γ (IFN-γ) mRNA expression in renal tissues, as well as NF-κB p65, intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin mRNA expression in tail vein vascular tissues of thrombotic mice. Western blot analysis showed that LP-KFY05 also down-regulated NF-κB protein expression in renal and tail vein vascular tissues of thrombotic mice. Lastly, LP-KFY05 increased the abundances of Bacteroidetes, Lactobacillus, and Bifidobacterium, as well as decreased the abundance of Firmicutes. These results show that LP-KFY05 can reduce inflammation and inhibit thrombosis in thrombotic mice, and the effects of high concentrations of LP-KFY05 were most pronounced, which were similar to the effects of dipyridamole.

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Systemic immune-inflammation index and incident cardiovascular diseases among middle-aged and elderly Chinese adults: The Dongfeng-Tongji cohort study

Cited by 114 publications

References 52 publications

Systemic Immune-Inflammation Index Predicted Short-Term Outcomes in Patients Undergoing Isolated Tricuspid Valve Surgery

Systemic Immune-Inflammation Index Predicted Short-Term Outcomes in Patients Undergoing Isolated Tricuspid Valve Surgery

Value of the Systemic Immune-Inflammatory Index (SII) in Predicting the Prognosis of Patients With Peripartum Cardiomyopathy

Lactobacillus plantarum HFY05 Attenuates Carrageenan-Induced Thrombosis in Mice by Regulating NF-κB Pathway-Associated Inflammatory Responses

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