Systemic immune-inflammation index is associated with diabetic kidney disease in Type 2 diabetes mellitus patients: Evidence from NHANES 2011-2018

Guo, Wenbo; Song, Yancheng; Sun, Yan; Du, Huasheng; Cai, Yan; You, Qingqing; Fu, Hongbo; Shao, Leping

doi:10.3389/fendo.2022.1071465

Cited by 125 publications

(88 citation statements)

References 59 publications

(68 reference statements)

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“…Increased SII was associated with poor survival in ASCVD patients. Guo et al [ 32 ] found that SII levels in T2DM patients were associated with the development of diabetic kidney disease (DKD). SII may be a cost-effective and simple method to detect DKD.…”

Section: Discussionmentioning

confidence: 99%

The association between systemic immune-inflammation index and rheumatoid arthritis: evidence from NHANES 1999–2018

et al. 2023

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Purpose We aimed to explore the relationship between the systemic immune-inflammation index (SII) and rheumatoid arthritis (RA) using NHANES from 1999 to 2018. Methods We collected data from the NHANES database from 1999 to 2018. The SII is calculated from the counts of lymphocytes (LC), neutrophils (NC), and platelets (PC). The RA patients were derived from questionnaire data. We used weighted multivariate regression analysis and subgroup analysis to explore the relationship between SII and RA. Furthermore, the restricted cubic splines were used to explore the non-linear relationships. Result Our study included a total of 37,604 patients, of which 2642 (7.03%) had rheumatoid arthritis. After adjusting for all covariates, the multivariate logistic regression analysis showed that high SII (In-transform) levels were associated with an increased likelihood of rheumatoid arthritis (OR=1.167, 95% CI=1.025–1.328, P=0.020). The interaction test revealed no significant effect on this connection. In the restricted cubic spline regression model, the relationship between ln-SII and RA was non-linear. The cutoff value of SII for RA was 578.25. The risk of rheumatoid arthritis increases rapidly when SII exceeds the cutoff value. Conclusion In general, there is a positive correlation between SII and rheumatoid arthritis. Our study shows that SII is a novel, valuable, and convenient inflammatory marker that can be used to predict the risk of rheumatoid arthritis in US adults.

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Section: Discussionmentioning

confidence: 99%

The association between systemic immune-inflammation index and rheumatoid arthritis: evidence from NHANES 1999–2018

et al. 2023

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“…A cross-sectional study found that ln-SII at baseline was associated with all causes of death from any cause in the United States ASCVD population in the NHANES group [22]. Increased SII in ASCVD individuals is related to poor survival [23].In addition, higher levels of SII are related to an increased risk of hepatic steatosis[8], peripheral arterial disease [9], isolated coronary artery ectasia [10], urinary albuminuria excretion [5], diabetic kidney disease [11], and diabetic depression [12]. Likewise, T2DM patients were more likely to have elevated SII in our subgroup analysis compared with those who did not have T2DM, Indicating that in ammation may be signi cantly involved in developing T2DM.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, in ammatory markers, like SII, can also be used in the treatment of complications of T2DM. Guo et al found that T2DM patients had an increased SII in association with diabetic kidney disease [11].…”

Section: Discussionmentioning

confidence: 99%

“…SII, as a strong predictive factor, has been reported to be superior to conventional risk factors in the prediction of major cardiovascular events for CHD patients after coronary intervention [6].In addition, a statistically signi cant relationship between SII and higher BMI has been shown in earlier cross-sectional studies [7]. Furthermore, higher SII is correlated with an increased risk of liver steatosis [8], peripheral arterial disease [9], isolated coronary artery ectasia [10], urinary albuminuria excretion [5], diabetic kidney disease [11], diabetic depression [12].…”

Section: Introductionmentioning

confidence: 99%

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The systemic immune-inflammation index is associated with Type 2 diabetes mellitus patients: Evidence from NHANES 2011-2018

Liu

Shang

Luo

et al. 2023

Preprint

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Backgrounds The Systemic Immune-Inflammation Index (SII), as a novel inflammatory biomarker, has not been researched for type 2 diabetes mellitus (T2DM). This study was designed to investigate the potential association between SII and T2DM. Methods This cross-sectional study focused on adults enrolled in 2011 and 2018 by National Health and Nutrition Examination Survey (NHANES). Univariate, as well as multivariate logistic regression analyses, subgroup analyses, and sensitivity analyses, were performed to determine the independent association between SII and T2DM. The relationship between ln-SII and T2DM was described by the fitted smoothing curve. Results A total of 10,321 subjects were enrolled in the study; of which 2,078 (20.1%) were diagnosed with T2DM. After full adjustment, multivariate logistic regression demonstrated that higher SII was an independent risk factor for increased T2DM (OR = 1.30; 95% CI, 1.08–1.56, p < 0.0001). There was no relevant association of age, race, physical activity, high blood pressure, and smoking status(all p < 0.05), as demonstrated by the subgroup analysis and the interaction study. In addition, the relationship between SII and T2DM is non-linear; as ln-SII increases, the potential for T2DM gradually increases. Conclusions Elevated SII levels were linked to a higher probability of developing T2DM. More large and prospective studies will be required to confirm the results of this study.

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“…Recent studies have found that the ratios of different blood cell components are new in ammatory and immunoreactive markers, such as neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), platelet-lymphocytes ratio (PLR), and systemic immune-in ammation index (SII, calculated by platelet count × neutrophil count/lymphocyte count), which have good predictive value in the outcome of cancer, chronic kidney disease, cardiovascular disease, rheumatic disease, type 2 diabetes, metabolic syndrome, and so on [10][11][12][13][14][15][16][17] . To our knowledge, limited studies have focused on evaluating the involvement of these markers in PMN, as well as their predictive value for treatment and progression in PMN.…”

Section: Introductionmentioning

confidence: 99%

The value of peripheral blood cell ratios in primary membranous nephropathy

Zhang

Dai

Zhang

et al. 2023

Preprint

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Background Primary membranous nephropathy (PMN) is a common cause of nephrotic syndrome in adults. Forty percent of the patients still continue to progress and worsen and eventually develop into chronic renal failure. Although phospholipase A2 receptor (PLA2R) is the major antigen of PMN in adults, the clinical features don’t often parallel with the antibody titers. Therefore, it is significant to find relative credible markers to predict the treatment response in patients with PMN. Methods In this study, 118 patients with PMN were recruited. The response to treatment was defined as ALB≥30g/L at 6 months and complete remission (CR) or not at the end of the follow-up visit. Renal outcome endpoint was defined as 50% or more Cr increase at the end. Results The patients with poor treatment effects had numerically higher platelet-lymphocytes ratio (PLR). Especially for patients with CR or not, the difference was near to statistic significant (P=0.095). It is noteworthy that when analyzing CR or not, the fitting of the binary logistic regression model including both PLA2R Ab titer and PLR (Hosmer-Lemeshow test: χ2=8.328, P=0.402; OR (PLA2R Ab titer) =1.002 (95% CI 1.000-1.004, P=0.042); OR (PLR) =1.006 (95% CI 0.999-1.013, P=0.098) was markedly better than that with only PLA2R Ab titer (Hosmer-Lemeshow test: χ2=13.885, P=0.016). The patients with renal function deterioration showed significantly higher monocyte-lymphocyte ratio (MLR) (0.26 (0.22-0.31) vs 0.18 (0.13-0.22), P=0.012). Conclusion PMN patients with poor treatment response tended to have higher PLR at the time of renal biopsy, and a higher MLR was associated with poor renal outcomes. Our findings suggested that PLR and MLR might be used to predict treatment efficacy and prognosis for PMN patients, respectively.

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Systemic immune-inflammation index is associated with diabetic kidney disease in Type 2 diabetes mellitus patients: Evidence from NHANES 2011-2018

Cited by 125 publications

References 59 publications

The association between systemic immune-inflammation index and rheumatoid arthritis: evidence from NHANES 1999–2018

The association between systemic immune-inflammation index and rheumatoid arthritis: evidence from NHANES 1999–2018

The systemic immune-inflammation index is associated with Type 2 diabetes mellitus patients: Evidence from NHANES 2011-2018

The value of peripheral blood cell ratios in primary membranous nephropathy

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