Systemic Inflammation and Lung Function Impairment in Morbidly Obese Subjects with the Metabolic Syndrome

Huisstede, Astrid van; Cabezas, Manuel Castro; Birnie, Erwin; Geijn, Gert‐Jan M. van de; Rudolphus, Arjan; Mannaerts, G. H. H.; Njo, Tjin L.; Hiemstra, Pieter S.; Braunstahl, Gert‐Jan

doi:10.1155/2013/131349

Cited by 47 publications

(51 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Abdominal obesity is often correlated with reduced FVC and FEV (7,23). In the present study, obese adolescents had increased concentrations of abdominal fat, a fact observed during the measurement of waist circumference which was decreased significantly after exercise intervention.…”

Section: Discussionsupporting

confidence: 54%

The Effects of Selected Aerobic Exercises on Pulmonary Functions of High School Obese Girls

Irandoust

2015

Int J School Health

View full text Add to dashboard Cite

Background: Aerobic exercise is an important component of pulmonary functions for obese adolescents. There are few studies on aerobic exercise and pulmonary function in obese adolescence. Objectives: The purpose of this study was to investigate the effect of selected aerobic exercise training on some pulmonary function of Iranian obese girls. Patients and Methods: Forty-five, apparently obese adolescence, aged 14 -15 years were randomly divided into three groups (15 subjects in each group) including rope skipping; jogging and control groups. Experimental groups participated in a twelve-week program (3 sessions a week, each session for 45 minutes) while control group had no plan of exercise. A spirometry test was taken 24 hours before and after the training protocol. Statistical analysis using the one-way analysis of variance was used (P < 0.05). Results:The results suggested that all anthropometric characteristics of both experimental groups including weight, body mass index (BMI), percent body fat (PBF), waist-hip ratio (WHR) were significantly improved after exercise protocol, furthermore, ventilation capacity (VC), forced vital capacity (FVC), forced expiratory volume in the first second (FEV1) were significantly improved in experimental groups compared to control group (P < 0.001), while no significant difference was found between two experimental groups in ventilation functions (P > 0.001). Conclusions: We conclude that appropriate aerobic exercise can improve lung function in obese adolescence.

show abstract

Section: Discussionsupporting

confidence: 54%

The Effects of Selected Aerobic Exercises on Pulmonary Functions of High School Obese Girls

Irandoust

2015

Int J School Health

View full text Add to dashboard Cite

show abstract

“…However, that study did not include subjects with asthma, and the observed association was likely mediated by peripheral blood eosinophilia(47). We did not find that one particular component of the metabolic syndrome explained our results; however, WC was most consistently associated with the outcomes of interest.…”

Section: Discussionmentioning

confidence: 99%

Insulin resistance, metabolic syndrome, and lung function in US adolescents with and without asthma

Forno

Han

Muzumdar

et al. 2015

Journal of Allergy and Clinical Immunology

149

107

View full text Add to dashboard Cite

Background Obesity increases the risk of asthma and asthma severity and is a well-known risk factor for insulin resistance and the metabolic syndrome (MS) in children and adolescents. Objective We aim to examine the association among obesity, insulin sensitivity, metabolic syndrome, and lung function in U.S. adolescents with and without asthma. Methods Cross-sectional study 1,429 adolescents aged 12–17 years in the 2007–2010 National Health and Nutrition Examination Survey. Adjusted regression was used to assess the relationships among obesity, insulin sensitivity/resistance, metabolic syndrome, and lung function in children with and without asthma. Results Insulin resistance was negatively associated with FEV1 and FVC in adolescents with and without asthma, while MS was associated with lower FEV1/FVC, with a more pronounced decrease among asthmatics; these associations were driven by overweight/obese adolescents. Higher BMI was associated with a decrease in FEV1/FVC among adolescents with insulin resistance. Compared to healthy participants, adolescents with MS had a ~2% decrease in FEV1/FVC; adolescents with asthma had a ~6% decrease; and those with MS and asthma had ~10% decreased FEV1/FVC (p<0.05). Conclusion Insulin resistance and MS are associated with worsened lung function in overweight/obese adolescents. Asthma and MS synergistically decrease lung function, as do obesity and insulin resistance. These factors may contribute to the pathogenesis of asthma severity in obese patients and warrant further investigation.

show abstract

“…There is also growing evidence that the metabolic syndrome (abdominal obesity, insulin resistance, hypertension and dyslipidaemia) is a strong risk factor for asthma, even stronger than obesity [29]. A study by VAN HUISSTEDE et al [30] showed a correlation between eosinophilia, lung function and metabolic syndrome, while no correlation was observed for BMI. The possible causal connections between endometriosis and asthma, and the metabolic syndrome and asthma could be some of the explanatory factors behind the impaired fertility of asthma patients, as both diseases are known to reduce fertility [31,32].…”

Section: Discussionmentioning

confidence: 99%

Asthma affects time to pregnancy and fertility: a register-based twin study

Gade

Thomsen

Lindenberg³

et al. 2013

Eur Respir J

View full text Add to dashboard Cite

Coexistence of infertility and asthma has been observed clinically. Therefore, we investigated the association between asthma and delayed pregnancy in a nationwide population-based cohort of twins.A cohort of 15 250 twins living in Denmark (aged 12-41 years) participated in a questionnaire study including questions about the presence of asthma and fertility. Differences in time to pregnancy and pregnancy outcome were analysed in subjects with asthma, allergy and in healthy individuals using multiple regression analysis.Asthma was associated with an increased time to pregnancy, the percentage of asthmatics with a time to pregnancy .1 year was 27% versus 21.6% for non-asthmatics (OR (95% CI) 1.31 (1.1-1.6); p50.009). The association remained significant after adjustment for age, age at menarche, body mass index and socioeconomic status (OR (95% CI) 1.25 (1.0-1.6); p50.05), and was more pronounced in those .30 years of age (32.2% versus 24.9%, OR (95% CI) 1.44 (1.1-1.9); p50.04). Untreated asthmatics had a significant increased risk of prolonged time to pregnancy compared to healthy individuals (OR (95% CI) 1.79 (1.20-2.66); p50.004), while asthmatics receiving any kind of treatment for asthma tended to have a shorter time to pregnancy than untreated asthmatics (OR 1.40; p50.134).Asthma prolongs time to pregnancy. The negative effect of asthma on fertility increases with age and with disease intensity, indicating that a systemic disease characterised by systemic inflammation also can involve reproductive processes. @ERSpublications Asthma prolongs time to pregnancy: the negative effect of asthma on fertility increases with age and disease intensity

show abstract

Systemic Inflammation and Lung Function Impairment in Morbidly Obese Subjects with the Metabolic Syndrome

Cited by 47 publications

References 37 publications

The Effects of Selected Aerobic Exercises on Pulmonary Functions of High School Obese Girls

The Effects of Selected Aerobic Exercises on Pulmonary Functions of High School Obese Girls

Insulin resistance, metabolic syndrome, and lung function in US adolescents with and without asthma

Asthma affects time to pregnancy and fertility: a register-based twin study

Contact Info

Product

Resources

About