Systemic inflammation in peripheral arterial disease with or without coexistent chronic obstructive pulmonary disease: analysis of selected markers

Woźniak, Krzysztof; Śleszycka, Justyna; Safianowska, Aleksandra; Wiechno, W; Domagała‐Kulawik, Joanna

doi:10.5114/aoms.2012.29525

Cited by 10 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Acute lung injury is characterized by the excess production of inflammatory factors in the lung, and is a leading and increasing cause of high morbidity and mortality worldwide [15,27]. Acute lung injury, which is accompanied by leukocyte influx [24], can be triggered by both infectious and noninfectious stimuli, including influenza virus (e.g., pandemic H1N1 2009 influenza A virus, H1N1) and endotoxin (e.g., lipopolysaccharide, LPS).…”

Section: Introductionmentioning

confidence: 99%

Apios americana Medik Extract Alleviates Lung Inflammation in Influenza Virus H1N1- and Endotoxin-Induced Acute Lung Injury

Sohn¹,

Lee²,

Cui³

et al. 2015

Journal of Microbiology and Biotechnology

View full text Add to dashboard Cite

Apios americana Medik (hereinafter Apios) has been reported to treat diseases, including cancer, hypertension, obesity, and diabetes. The therapeutic effect of Apios is likely to be associated with its anti-inflammatory activity. This study was conducted to evaluate the protective effects of Apios in animal models of acute lung injury induced by lipopolysaccharide (LPS) or pandemic H1N1 2009 influenza A virus (H1N1). Mice were exposed to LPS or H1N1 for 2-4 days to induce acute lung injury. The treatment groups were administered Apios extracts via oral injection for 8 weeks before LPS treatment or H1N1 infection. To investigate the effects of Apios, we assessed the mice for in vivo effects of Apios on immune cell infiltration and the level of pro-inflammatory cytokines in the bronchoalveolar lavage (BAL) fluid, and histopathological changes in the lung. After induction of acute lung injury, the numbers of neutrophils and total cells were lower in the Apios-treated groups than in the non-Apios-treated LPS and H1N1 groups. The Apios groups tended to have lower levels of tumor necrosis factor-a and interleukin-6 in BAL fluid. In addition, the histopathological changes in the lungs were markedly reduced in the Apios-treated groups. These data suggest that Apios treatment reduces LPS- and H1N1-induced lung inflammation. These protective effects of Apios suggest that it may have therapeutic potential in acute lung injury.

show abstract

Section: Introductionmentioning

confidence: 99%

Apios americana Medik Extract Alleviates Lung Inflammation in Influenza Virus H1N1- and Endotoxin-Induced Acute Lung Injury

Sohn¹,

Lee²,

Cui³

et al. 2015

Journal of Microbiology and Biotechnology

View full text Add to dashboard Cite

show abstract

“…Study of Wozniak et al demonstrated that serum concentrations of infl ammatory biomarkers are similar to that observed in the chronic obstructive pulmonary disease (COPD). Thus the patients with PAD exert similar infl ammatory status that can be seen in COPD (23). Unfortunately despite many studies no single biomarker has been identifi ed to be a strong predictor of atherosclerosis and PAD as well.…”

Section: Discussionmentioning

confidence: 92%

“…Besides CRP, IL-6, TNF-alpha some other markers have been found to be associated with PAD, namely VCAM-1, ICAM, selectins, IL-8, fi brinogen, natriuretic peptides etc. (23,24). Study of Wozniak et al demonstrated that serum concentrations of infl ammatory biomarkers are similar to that observed in the chronic obstructive pulmonary disease (COPD).…”

Section: Discussionmentioning

confidence: 99%

Humoral predictors of ankle-brachial index in patients with peripheral arterial disease and controls

Valkova¹,

Lazúrová²,

Petrášová³

et al. 2018

BLL

View full text Add to dashboard Cite

INTRODUCTION: Peripheral arterial disease (PAD) is a common condition due to atherosclerosis with high prevalence in population over 55 years. Although its pathophysiology is well recognized, the role of infl ammatory markers is still not fully known. OBJECTIVES: The aim of the study was to assess the relation of C-reactive protein (CRP), tumor necrosis factors-alpha (TNF-alpha) and interleukin-6 (IL-6) to ankle-brachial index (ABI) and metabolic variables in patients with PAD. The second aim was to fi nd the most signifi cant humoral predictor of ABI. PATIENTS AND METHODS: The study groups consisted of 55 patients (36 men and 19 women) diagnosed with PAD (age 63.65 ± 6.11 years) and 34 control subjects (7 men, 27 women) of average age 59.88 ± 6.10 years with ABI > 0.9. Blood samples were analyzed for glycaemia, lipid profi le and infl ammatory markers (CRP, TNF-alpha and IL-6). RESULTS: A signifi cantly higher serum total cholesterol (p = 0.04), triglycerides (p = 0.005) and lower HDL cholesterol (p < 0.0001) were found in the PAD group as compared to controls. Patients with PAD had significantly higher serum glucose (p = 0.008), CRP (p = 0.0044), IL-6 (p < 0.0001) and TNF-α (p < 0.0001) in comparison to controls. In a multiple linear regression analysis among variables log IL-6 and log HDL cholesterol were most signifi cantly related to ABI (LW 4.75 for log IL-6, LW 4.016 for log HDL cholesterol, respectively, p < 0.01) in all subjects. CONCLUSIONS: We conclude that among traditional and humoral risk factors IL-6 is the strongest predictor of ABI. HDL cholesterol is also signifi cant and strong predictor of decreased ABI and could be a potential biomarker of PAD in patients using lipid lowering drugs (Tab. 1, Ref. 31).

show abstract

“…It is characterized by excess production of inammatory factors in lung tissue followed by severe hypoxemia and pulmonary edema, which even can cause acute respiratory distress syndrome (ARDS). 1,2 ALI has gradually become a global public health problem due to its high incidence, morbidity and mortality. Despite extensive studies about the relevant pathogenesis having been reported to date, no effective therapeutic agents are available for ALI.…”

Section: Introductionmentioning

confidence: 99%

Tissue metabolomic profiling to reveal the therapeutic mechanism of reduning injection on LPS-induced acute lung injury rats

et al. 2018

View full text Add to dashboard Cite

show abstract

Systemic inflammation in peripheral arterial disease with or without coexistent chronic obstructive pulmonary disease: analysis of selected markers

Cited by 10 publications

References 23 publications

Apios americana Medik Extract Alleviates Lung Inflammation in Influenza Virus H1N1- and Endotoxin-Induced Acute Lung Injury

Apios americana Medik Extract Alleviates Lung Inflammation in Influenza Virus H1N1- and Endotoxin-Induced Acute Lung Injury

Humoral predictors of ankle-brachial index in patients with peripheral arterial disease and controls

Tissue metabolomic profiling to reveal the therapeutic mechanism of reduning injection on LPS-induced acute lung injury rats

Contact Info

Product

Resources

About