2009
DOI: 10.1097/shk.0b013e3181a2bcd6
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Systemic Inflammation Increases Intestinal Permeability During Experimental Human Endotoxemia

Abstract: Although the gut is often considered the motor of sepsis, the relation between systemic inflammation and intestinal permeability in humans is not clear. We analyzed intestinal permeability during experimental endotoxemia in humans. Before and during experimental endotoxemia (Escherichia coli LPS, 2 ng/kg), using polyethylene glycol (PEG) as a permeability marker, intestinal permeability was analyzed in 14 healthy subjects. Enterocyte damage was determined by intestinal fatty acid binding protein. Endotoxemia i… Show more

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Cited by 124 publications
(89 citation statements)
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“…LPS increases the permeability of Caco-2 cells when administered to the basolateral side (12). In humans, systemically given LPS increases intestinal permeability (13). These reports provide a basis for the claim that LPS aggravates barrier dysfunction and is involved in the pathogenesis of disorders related to a leaky gut but is not involved in the initiation of luminally derived barrier dysfunction.…”
mentioning
confidence: 73%
“…LPS increases the permeability of Caco-2 cells when administered to the basolateral side (12). In humans, systemically given LPS increases intestinal permeability (13). These reports provide a basis for the claim that LPS aggravates barrier dysfunction and is involved in the pathogenesis of disorders related to a leaky gut but is not involved in the initiation of luminally derived barrier dysfunction.…”
mentioning
confidence: 73%
“…Increased gut permeability is well documented in humans during endotoxemia and other systemic inflammatory conditions such as pancreatitis. 68,69 Similarly, altered gut permeability could have an important role in the pathogenesis of TSS in humans. Further studies are needed to address these issues, and the described HLA-II transgenic mouse model will be a valuable tool for dissection of the immunopathogenesis of TSS.…”
Section: Discussionmentioning
confidence: 99%
“…The disruption of the epithelial barrier resulting from mucosal alterations leads to interactions among microorganisms, bacterial antigens, endotoxins of the intestinal lumen with the mucosal and submucosal immune system. The stimulation of innate immunity will result in local then systemic inflammatory pathways activation such as TLR, NF-ÎșB or TNF [13,14]. Through the bloodstream, bacteria, endotoxins, cells degradation products and activated immune cells translocate and promote SIRS.…”
Section: Multistep Pathophysiologymentioning
confidence: 99%