Systemic inflammatory impact of periodontitis on acute coronary syndrome

Widén, Cecilia; Holmer, Helene; Coleman, Michael D.; Tudor, Marian; Ohlsson, Ola; Sättlin, Susanna; Renvert, Stefan; Persson, G. Rutger

doi:10.1111/jcpe.12540

Cited by 25 publications

(22 citation statements)

References 43 publications

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“…In this line, Allin et al observed a more favourable short‐term response to periodontal treatment in patients with lower cytokine/chemokine levels, and ZeinElabdeen et al reported lower plasma IL‐10, IL‐13, IL‐1Ra, MCP‐1, RANTES, G‐CSF and GM‐CSF concentrations in patients with aggressive periodontitis than in healthy controls . Other studies also found no association of periodontitis with TNF‐α or PCR, calling into question the role of cytokine serology as a reliable biomarker of systemic inflammation status . In advanced cognitive impairment, serum biomarkers may no longer be detectable, but could potentially be found in the cerebrospinal fluid (CSF).…”

Section: Discussionmentioning

confidence: 99%

“…However, studies in patients with cardiovascular disease failed to establish positive associations among periodontitis, systemic inflammation and cardiovascular disease . The most recent investigation found that a subset of 23 cytokines in sera from periodontal and non‐periodontal patients did not contribute to the diagnosis of acute ischaemic heart disease …”

Section: Introductionmentioning

confidence: 99%

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Systemic inflammatory impact of periodontitis on cognitive impairment

et al. 2019

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Objectives The role in dementia of systemic inflammation derived from periodontal disease is not fully elucidated. The objective of our study was to examine the impact of inflammation on the relationship between periodontitis and cognitive impairment. Methods We have designed a case (n = 171) and control (n = 131) study to determine the periodontal health status, grade of cognitive impairment/dementia and systemic inflammation level, the last being measured by analysis of 29 inflammatory biomarkers using multiplex techniques. Results At the time of sampling, 11 of the 29 inflammatory biomarkers were associated with cognitive impairment in patients with more severe periodontitis. However, the inflammatory response to severe periodontitis was more reduced (lower biomarker concentrations) in cases (with cognitive impairment or dementia) than in (cognitively healthy) controls, an unexpected finding. Conclusions Based on these results, we cannot confirm that systemic inflammation derived from periodontal disease plays a relevant role in the aetiology of cognitive impairment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Systemic inflammatory impact of periodontitis on cognitive impairment

et al. 2019

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“…For these assays, duplicate readings were performed on a subset of samples to demonstrate a high level of correlation between measurements; intra‐class correction varied between 0.95 and 1.0 ( P < .001) …”

Section: Methodsmentioning

confidence: 99%

Increased systemic levels of inflammatory mediators following one‐stage full‐mouth scaling and root planing

Morozumi

Yashima

Gomi

et al. 2018

J of Periodontal Research

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“…These include diabetes mellitus,24,25 rheumatoid arthritis,25,26 and cardiovascular diseases. The increased prevalence of cardiovascular disease,27,28 hypertension,25 and stroke in periodontal disease25,29 has been attributed to a common susceptibility hypothesis, that of direct bacterial invasion of blood vessels, and/or a systemic inflammatory response leading to increased circulating cytokines that damage vascular endothelium 30. Importantly, treating periodontitis in patients with common comorbidities has shown to be an effective way of reducing both financial costs and admissions for cardiovascular disease and diabetes mellitus,31 lending credence to this hypothesis.…”

Section: Periodontitismentioning

confidence: 99%

Is periodontitis a comorbidity of COPD or can associations be explained by shared risk factors/behaviors?

Hobbins¹,

Chapple

Sapey³

et al. 2017

COPD

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COPD is recognized as having a series of comorbidities potentially related to common inflammatory processes. Periodontitis is one of the most common human inflammatory diseases and has previously been associated with COPD in numerous observational studies. As periodontitis and COPD are both chronic, progressive conditions characterized by neutrophilic inflammation with subsequent proteolytic destruction of connective tissue, it has been proposed that they share common pathophysiological processes. The mechanisms proposed to link COPD and periodontitis include mechanical aspiration of oral contents into the respiratory tree, overspill of locally produced inflammatory mediators into the systemic circulation or oral or lung-derived bacteremia activating an acute-phase response and also reactive oxygen species (ROS) and cytokine release by systemic neutrophils at distant sites. Studies of systemic neutrophils in COPD and chronic periodontitis describe altered cellular functions that would predispose to inflammation and tissue destruction both in the lung and in the mouth, again potentially connecting these conditions. However, COPD and periodontitis also share risk factors such as age, chronic tobacco smoke exposure, and social deprivation that are not always considered in observational and interventional studies. Furthermore, studies reporting associations have often utilized differing definitions of both COPD and periodontitis. This article reviews the current available evidence supporting the hypothesis that COPD and inflammatory periodontal disease (periodontitis) could be pathologically associated, including a review of shared inflammatory mechanisms. It highlights the potential limitations of previous studies, in particular, the lack of uniformly applied case definitions for both COPD and periodontitis and poor recognition of shared risk factors. Understanding associations between these conditions may inform why patients with COPD suffer such a burden of comorbid illness and new therapeutic strategies for both the diseases. However, further research is needed to clarify factors that may be directly causal as opposed to confounding relationships.

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Systemic inflammatory impact of periodontitis on acute coronary syndrome

Abstract: Elevated serum levels of VEGF were associated with ACS. Serum cytokine expression in individuals with ACS is unrelated to periodontal conditions.

Cited by 25 publications

References 43 publications

Systemic inflammatory impact of periodontitis on cognitive impairment

Systemic inflammatory impact of periodontitis on cognitive impairment

Increased systemic levels of inflammatory mediators following one‐stage full‐mouth scaling and root planing

Is periodontitis a comorbidity of COPD or can associations be explained by shared risk factors/behaviors?

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