Systemic involvement and immunologic findings in patients presenting with Raynaud's phenomenon

Kallenberg, Cees G. M.; Wouda, A. A.

doi:10.1016/0002-9343(80)90417-9

Cited by 64 publications

(20 citation statements)

References 13 publications

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“…Our study showed a 10-year mortality rate of 28.2%, supporting the previous data. The relationship between Raynaud's phenomenon and prognosis has been previously noted, as have the correlations between the degree of severity and the presence of other connective tissue disease manifestations (46) and the number of affected organs (47). We have shown an additional correlation with mortality.…”

Section: Discussionsupporting

confidence: 74%

Hla type as a predictor of mixed connective tissue disease differentiation ten‐year clinical and immunogenetic followup of 46 patients

Gendi

Welsh

Venrooij

et al. 1995

Arthritis & Rheumatism

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Objective. To determine any clinical or genetic markers of differentiation and outcome in a previously described cohort of 46 patients with mixed connective tissue disease (MCTD).Methods. Patients were clinically evaluated, chart notes reviewed, and HLA subtyping and immunology profiles performed where possible. Eleven had died and 7 were lost to followup.Results. MCTD had differentiated into systemic lupus erythematosus in 12 patients and into systemic sclerosis in 13. The latter was associated with HLA-DR5 (P = 0.038), and nondifferentiation was associated with HLA-DR2 or DR4 (P = 0.007). Three HLA-DR4 positive patients had MCTD that evolved into rheumatoid arthritis. Erosive and/or deforming arthritis was associated with HLA-DR1 or DR4 (P = 0.015). HLA-DR3 was associated with interstitial lung fibrosis (P = 0.044) and keratoconjunctivitis sicca (0.001 < P < 0.01). Severe Raynaud's phenomenon predicted higher mortality (0.01 < P < 0.05). Conclusion.We suggest that MCTD is, for most patients, an intermediate stage in a genetically determined progression to a recognized connective tissue disease. Those whose disease remains undifferentiated might be considered a distinct subset.

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Section: Discussionsupporting

confidence: 74%

Hla type as a predictor of mixed connective tissue disease differentiation ten‐year clinical and immunogenetic followup of 46 patients

Gendi

Welsh

Venrooij

et al. 1995

Arthritis & Rheumatism

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“…In collagen diseases such as scleroderma and SLE, antinuclear antibody is suspected to be related to vascular disorders such as Raynaud's phenomenon and thrombophlebitis. 3,12) In our patient, scleroderma was complicated by SVT and peroneal vein thrombosis, and antinuclear antibody was positive at 1:160 with a speckled stain pattern or 1:1,280 or higher with a centromere pattern. Characteristics different from those of non-collagen disease deep vein thrombosis are suggested.…”

Section: Discussionmentioning

confidence: 50%

Relation between Isolated Venous Thrombi in Soleal Muscle and Positive Anti-Nuclear Antibody

Ohgi

2012

Annals of Vascular Diseases

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“…The most useful indications for predicting the evolution of CTD in patients with suspected secondary RP described thus far are digital pitting scars or puffy fingers, the pres ence of antinuclear antibodies and a capillaroscopy examination that shows morphological alterations of ves sels [8,9], The presence of antinuclear antibodies in patients with RP may be a further sign of the development of a systemic disease. Moreover, the autoantibody titers correlate with the number of affected organs, although they have no clinical expression and can only be demon strated by means of performing complementary explora tions [4]. An abnormal capillaroscopy examination usu ally signals the development of progressive systemic scle rosis, but this technique was not altered in our case [1].…”

Section: Discussionmentioning

confidence: 95%

Raynaud’s Phenomenon with Digital Necrosis as the First Manifestation of Undifferentiated Connective Tissue Syndrome

Sabán¹,

Rodríguez-García²,

Pais³

et al. 1991

Dermatology

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A patient with severe Raynaud’s phenomenon (RP) associated with the presence of antibodies against extractable nuclear antigen (ribonucleoprotein) in the context of undifferentiated connective tissue syndrome is presented. The rapid course of digital necrosis in her case resulted in the surgical amputation of 9 of her fingers. We conclude that massive digital necrosis accompanied by severe RP could constitute the first manifestation of a connective tissue disease.

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Systemic involvement and immunologic findings in patients presenting with Raynaud's phenomenon

Cited by 64 publications

References 13 publications

Hla type as a predictor of mixed connective tissue disease differentiation ten‐year clinical and immunogenetic followup of 46 patients

Hla type as a predictor of mixed connective tissue disease differentiation ten‐year clinical and immunogenetic followup of 46 patients

Relation between Isolated Venous Thrombi in Soleal Muscle and Positive Anti-Nuclear Antibody

Raynaud’s Phenomenon with Digital Necrosis as the First Manifestation of Undifferentiated Connective Tissue Syndrome

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