Systemic Levels of Interleukin-6 Correlate With Progression Rate of Geographic Atrophy Secondary to Age-Related Macular Degeneration

Nielsen, Marie Krogh; Subhi, Yousif; Molbech, Christopher Rue; Falk, Mads Krüger; Nissen, Mogens Holst; Sørensen, Torben Lykke

doi:10.1167/iovs.18-25878

Cited by 63 publications

(60 citation statements)

References 49 publications

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“…However, CCR5 is expressed on monocytes during inflammation, and CCR5+ monocytes play a crucial role in orchestrating an appropriate sepsis immune response. 34 In this study, CCR5 expression on monocytes is slightly increased in patients with late-stage AMD, which is in line with the association between both late stages of AMD and systemic low-grade chronic inflammation, with the highest levels in patients with GA. 20,23 Plasma levels of CCL5 increases as a function of age and "inflammaging," 35 therefore it is not surprising to find this chemokine increased in aged individuals and in patients with GA, whom we have previously found to have accelerated immunological aging and chronic inflammation. 20 Rentzos et al 36 reports a similar increase in plasma CCL5 in patients with Parkinson disease.…”

Section: Discussionmentioning

confidence: 96%

“…34 In this study, CCR5 expression on monocytes is slightly increased in patients with late-stage AMD, which is in line with the association between both late stages of AMD and systemic low-grade chronic inflammation, with the highest levels in patients with GA. 20,23 Plasma levels of CCL5 increases as a function of age and "inflammaging," 35 therefore it is not surprising to find this chemokine increased in aged individuals and in patients with GA, whom we have previously found to have accelerated immunological aging and chronic inflammation. 20 Rentzos et al 36 reports a similar increase in plasma CCL5 in patients with Parkinson disease. Interestingly, one study developed an in vitro blood-brain-barrier using SV40 T-antigen immortalized human brain microvascular endothelial cells, which did not secrete CCL5 under homeostatic conditions, but when stimulated with proinflammatory cytokines there was a dose-dependent increase in CCL5 production by the cells, simultaneously with a marked degraded barrier function.…”

Section: Discussionmentioning

confidence: 96%

“…The procedures used for analysis and grading of autofluorescence images have been published elsewhere. 20…”

Section: Enlargement Rate Of Atrophic Lesion In Gamentioning

confidence: 99%

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Chemokine Profile and the Alterations in CCR5-CCL5 Axis in Geographic Atrophy Secondary to Age-Related Macular Degeneration

Nielsen

Subhi

Molbech

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 96%

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Chemokine Profile and the Alterations in CCR5-CCL5 Axis in Geographic Atrophy Secondary to Age-Related Macular Degeneration

Nielsen

Subhi

Molbech

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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“…Interleukin 6 (IL‐6) is a cytokine produced by macrophages and T‐cells. Three prospective studies reported that systemic IL‐6 levels are positively correlated with the development of early AMD, progression to late AMD, and faster GA growth . Other interleukins, including IL‐1 β, IL‐8, and IL‐10, have also been studied in AMD, though to a lesser extent, and no relation has been found between these other interleukins and disease progression in AMD …”

Section: Molecular Risk Factorsmentioning

confidence: 99%

“…One longitudinal population study found a positive relation between TNF‐αR2 levels and early AMD development . However, other studies found no association with the development of late AMD or GA growth …”

Section: Molecular Risk Factorsmentioning

confidence: 99%

Risk factors for progression of age‐related macular degeneration

Heesterbeek

Lorés‐Motta

Hoyng

et al. 2020

Ophthalmic Physiologic Optic

255

224

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Purpose Age‐related macular degeneration (AMD) is a degenerative disease of the macula, often leading to progressive vision loss. The rate of disease progression can vary among individuals and has been associated with multiple risk factors. In this review, we provide an overview of the current literature investigating phenotypic, demographic, environmental, genetic, and molecular risk factors, and propose the most consistently identified risk factors for disease progression in AMD based on these studies. Finally, we describe the potential use of these risk factors for personalised healthcare. Recent findings While phenotypic risk factors such as drusen and pigment abnormalities become more important to predict disease progression during the course of the disease, demographic, environmental, genetic and molecular risk factors are more valuable at earlier disease stages. Demographic and environmental risk factors such as age and smoking are consistently reported to be related to disease progression, while other factors such as sex, body mass index (BMI) and education are less often associated. Of all known AMD variants, variants that are most consistently reported with disease progression are rs10922109 and rs570618 in CFH, rs116503776 in C2/CFB/SKIV2L, rs3750846 in ARMS2/HTRA1 and rs2230199 in C3. However, it seems likely that other AMD variants also contribute to disease progression but to a lesser extent. Rare variants have probably a large effect on disease progression in highly affected families. Furthermore, current prediction models do not include molecular risk factors, while these factors can be measured accurately in the blood. Possible promising molecular risk factors are High‐Density Lipoprotein Cholesterol (HDL‐C), Docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), zeaxanthin and lutein. Summary Phenotypic, demographic, environmental, genetic and molecular risk factors can be combined in prediction models to predict disease progression, but the selection of the proper risk factors for personalised risk prediction will differ among individuals and is dependent on their current disease stage. Future prediction models should include a wider set of genetic variants to determine the genetic risk more accurately, and rare variants should be taken into account in highly affected families. In addition, adding molecular factors in prediction models may lead to preventive strategies and personalised advice.

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Mesoporous Cerium Oxide Nanoparticles with High Scavenging Properties of Reactive Oxygen Species for Treating Age‐Related Macular Degeneration

Choi,

Kim,

Kim

2023

Advanced NanoBiomed Research

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Age‐related macular degeneration (AMD), the leading cause of vision loss among older individuals, is characterized by damage to photoreceptors and retinal pigment epithelial cells (RPEs). Oxidative stress and chronic inflammation in the retina play notable roles in AMD pathogenesis, rendering them attractive therapeutic targets. Cerium oxide nanoparticles (CeNPs) have shown promise in scavenging reactive oxygen species (ROS) by mimicking antioxidant enzymes, whereas mesoporous materials have emerged as versatile drug carriers. Herein, mesoporous CeNPs (mCeNPs) that integrate the advantages of CeNPs and mesoporous materials are presented. The mCeNPs can be synthesized using 1,1′‐carbonyldiimidazole and imidazole in acetone without heating and pressurization. The resulting mCeNPs exhibit mesoporous structures comprising assembled small CeNPs, exerting excellent ROS‐scavenging capabilities, biocompatibility, and cytoprotective and anti‐inflammatory effects against H2O2‐induced damage in RPEs. Using a sodium iodate‐induced AMD mouse model, it is demonstrated that intravitreal mCeNP administration can exhibit disease‐preventive effects. These findings indicate the therapeutic potential of mCeNPs against AMD.

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Systemic Levels of Interleukin-6 Correlate With Progression Rate of Geographic Atrophy Secondary to Age-Related Macular Degeneration

Abstract: levels of interleukin-6 correlate with progression rate of geographic atrophy secondary to age-related macular degeneration.

Cited by 63 publications

References 49 publications

Chemokine Profile and the Alterations in CCR5-CCL5 Axis in Geographic Atrophy Secondary to Age-Related Macular Degeneration

Chemokine Profile and the Alterations in CCR5-CCL5 Axis in Geographic Atrophy Secondary to Age-Related Macular Degeneration

Risk factors for progression of age‐related macular degeneration

Mesoporous Cerium Oxide Nanoparticles with High Scavenging Properties of Reactive Oxygen Species for Treating Age‐Related Macular Degeneration

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