Systemic lupus erythematosus and cardiovascular disease: prediction and potential for therapeutic intervention

McMahon, Maureen; Hahn, Bevra H.; Skaggs, Brian J.

doi:10.1586/eci.10.98

Cited by 94 publications

(76 citation statements)

References 200 publications

(229 reference statements)

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“…However, this should not have biased our results, as lupus-like illness is associated with accelerated, but not with reduced, atherosclerosis. 42 The lower IMT in carriers of NOX2 deficiency was another important evidence in favor of the reduced atherosclerotic burden in subjects with impaired ROS production. Thus, IMT is a noninvasive diagnostic measure of atherosclerosis that correlates with histology and predicts cardiovascular events, including myocardial infarction and stroke.…”

Section: Discussionmentioning

confidence: 99%

Reduced Atherosclerotic Burden in Subjects With Genetically Determined Low Oxidative Stress

Violi

Pignatelli

Pignata

et al. 2013

ATVB

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Objective-NADPH oxidase, one of the most important enzymes producing reactive oxidant species, is suggested to play a role in experimental atherosclerosis, but its role in human atherosclerosis is still unclear. We hypothesized that a reduced activity of NADPH oxidase might be linked to a reduced atherosclerotic burden. Methods and Results-Thirty-one women carriers of hereditary deficiency of NOX2, the catalytic subunit of NADPH oxidase, were matched for sex and age with 31 controls and 31 obese women. Flow-mediated dilation and intima-media thickness, 2 surrogate markers of atherosclerosis, serum activity of NOX2, urinary isoprostanes, serum levels of nitrite/ nitrate, and platelet production of isoprostanes and nitrite/nitrate were determined.

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Section: Discussionmentioning

confidence: 99%

Reduced Atherosclerotic Burden in Subjects With Genetically Determined Low Oxidative Stress

Violi

Pignatelli

Pignata

et al. 2013

ATVB

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“…Indeed, patients with SLE show a significant increased incidence of atherosclerosis and cardiovascular events when compared with healthy individuals. 64 The T1 IFN IFN-β is frequently used as a treatment of patients with relapsing remitting multiple sclerosis where it surprisingly has opposite effects on cerebral endothelial activation when compared with the peripheral endothelium. 65 About cell recruitment to the plaque, a recent in vivo study showed that T1 IFNs increased cell recruitment to atherosclerotic lesions in a CCL5-dependent manner.…”

Section: Ifns In Endothelial Activation and Cell Recruitmentmentioning

confidence: 99%

Interferons as Essential Modulators of Atherosclerosis

Boshuizen

Winther

2015

ATVB

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Abstract-Interferons (IFNs) are key regulators of both innate and adaptive immune responses. The family of IFN cytokines can be divided into 3 main subtypes of which type I and type II IFNs are most well-defined. IFNs are known to be important mediators in atherosclerosis. Evidence from both in vitro and in vivo studies shows that the IFNs are generally proatherosclerotic. However, their role in atherosclerosis is complex, with distinct roles for these cytokines throughout different stages of the disease. In this review, we will discuss the current knowledge on the role of type I and type II IFNs in atherosclerosis development, specifically focusing on their role in endothelial activation, cell recruitment, foam cell formation, and regulation of apoptosis. Furthermore, we will discuss whether IFNs could be considered as new molecular targets for therapeutic intervention in atherosclerosis. (Arterioscler Thromb Vasc Biol. 2015;35:1579-1588.

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“…It is well known that the cardiovascular disease (CVD) morbidity and mortality of patients with SLE is substantially increased as compared to the general population [1][2][3]. Moreover, CVD occurs at a younger age in SLE patients than in the general population [3,4].…”

Section: Introductionmentioning

confidence: 99%

The risk of pulmonary embolism and deep venous thrombosis in systemic lupus erythematosus: A general population-based study

Aviña‐Zubieta

Vostretsova

Vera

et al. 2015

Seminars in Arthritis and Rheumatism

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Objective-To estimate the future risk and time trends of newly diagnosed venous thromboembolism (VTE) in individuals with incident systemic lupus erythematosus (SLE) in the general population.Methods-Using a population-based database that includes all residents of British Columbia, Canada we conducted a study cohort of all patients with incident SLE and up to 10 age-, sex-, and entry-time-matched individuals from the general population. We compared incidence rates of pulmonary embolism (PE), deep venous thrombosis (DVT) and VTE between the two groups according to SLE disease duration. We calculated hazards ratios (HR), adjusting for confounders.Results-Among 4,863 individuals with SLE (86% female, mean age 48.9 years), the incidence rates (IRs) of PE, DVT, and VTE were 2.58, 3.33, and 5.32 per 1000 person-years, respectively, whereas the corresponding rates in the comparison cohort were 0.67, 0.57, and 1.11 per 1000 person-years. Compared with non-SLE individuals, the multivariable HRs among SLE patients were 3.04 (95% CI, 2.08-4.45), 4.46 (95% CI, 3.11-6.41) and 3.55 (95% CI, 2.69-4.69), respectively. The age-, sex-, and entry time-matched HRs for PE, DVT and VTE were highest Contributors: JAA-Z secured the funding source, and contributed to study conception, study design, data analysis/interpretation, and critical review of the manuscript. KV and MDV contributed to data analysis/interpretation and drafted the manuscript. ES contributed to data analysis and manuscript preparation. HKC secured some of the funding sources, and contributed to study conception/design, data analysis/interpretation, and critical review of the manuscript. Conclusion-These findings provide population-based evidence that patients with SLE have a substantially increased risk of VTE, especially in the first year after SLE diagnosis. Awareness and increased vigilance of this potentially fatal, but preventable, complication is recommended.

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Systemic lupus erythematosus and cardiovascular disease: prediction and potential for therapeutic intervention

Cited by 94 publications

References 200 publications

Reduced Atherosclerotic Burden in Subjects With Genetically Determined Low Oxidative Stress

Reduced Atherosclerotic Burden in Subjects With Genetically Determined Low Oxidative Stress

Interferons as Essential Modulators of Atherosclerosis

The risk of pulmonary embolism and deep venous thrombosis in systemic lupus erythematosus: A general population-based study

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