Systemic lupus erythematosus and infections: Clinical importance of conventional and upcoming biomarkers

Sciascia, Savino; Ceberio, Leticia; Garcia-Fernandez, Cesar; Roccatello, Dario; Karim, Mohammed Yousuf; Cuadrado, M J

doi:10.1016/j.autrev.2012.03.009

Cited by 69 publications

(41 citation statements)

References 48 publications

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“…In line with this, genome-wide association studies have already identified complement receptors and FcγRs as susceptibility genes in autoimmune conditions like SLE. In addition, FcγRI expression has been recently recognized as a new potential biomarker to assist clinical decisionmaking in the management of SLE patients [42,43].…”

Section: Integration Of the Fcγr And Complement Network Influencesmentioning

confidence: 99%

The role of Fc receptors and complement in autoimmunity

Mihai

Nimmerjahn

2013

Autoimmunity Reviews

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Section: Integration Of the Fcγr And Complement Network Influencesmentioning

confidence: 99%

The role of Fc receptors and complement in autoimmunity

Mihai

Nimmerjahn

2013

Autoimmunity Reviews

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“…Their value to predict disease flares and efficacy of therapeutics has been proven; however, even taken together, they are not specific and lack diagnostic accuracy in differentiating between flares and infections [47]. In SLE, unlike in other rheumatic diseases where increase in levels has been observed, changes in C-reactive protein (CRP) level have been less frequently observed during disease flares, proposing this marker as a valid tool to discriminate infection and lupus activity [48].…”

Section: Serological Markers Of Infection In Slementioning

confidence: 99%

Management of infection in systemic lupus erythematosus

Sciascia

Cuadrado

Karim

2013

Best Practice & Research Clinical Rheumatology

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Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterised by abnormal autoantibody production and clearance. This immunological background has been suggested to play a role in the susceptibility of SLE patients to infection. Moreover, drugs (most of them immunosuppressive or immunomodulating agents) used in the treatment of moderate and severe lupus give rise to a tendency for infections, including opportunistic ones. Infections may mimic the exacerbations of SLE, leading to confusion over the diagnosis and appropriate treatment. Despite increased awareness of this problem, infections remain a major source of morbidity and mortality in SLE. There are various strategies which can be applied to try and reduce the risk of infection in SLE patients. Options include vaccinations, antibiotic/antiviral prophylaxis and intravenous immunoglobulins.

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“…The relevant data show that the incidence of SLE in China is about 5/10,000: higher than in Japan, or European and American countries (Godarzi et al, 2011;Cui et al, 2013). Concurrently, there is evidence that the pathogenesis of SLE is associated with familial genetics (Shai et al, 1999;Wakeland et al, 2001;Mangale et al, 2013), ultraviolet radiation (McGrath Jr., 1994McGrath et al, 1996), estrogen levels in vivo (Lahita, 1999;Pierdominici and Ortona, 2013;Young et al, 2014), drugs (Fernandes Moça Trevisani et al, 2013;Gurevitz et al, 2013;Hahn, 2013), and food and infections (Sciascia et al, 2012;Touma et al, 2013), etc. However, the pathogenesis of SLE requires further investigation.…”

Section: Introductionmentioning

confidence: 99%

Analysis of interleukin 19 serum levels and single nucleotide polymorphisms in systemic lupus erythematosus

et al. 2016

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ABSTRACT. Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease that affects multiple organs and diminishes a patients' quality of life. It has been suggested that interleukin 19 (IL-19) is engaged in intercellular signal transduction, which is related to the immune response and the local inflammatory reaction. Single nucleotide polymorphisms (SNPs) have been used to explore the genetic basis underlying the pathogenesis of SLE. In this study, we investigated the potential correlation between the functional IL19 SNP rs2243188 and SLE. The frequency of allele C in rs2243188 was lower in the SLE population, particularly when the dominant inheritance model was applied. There was also a significant difference in the allele C frequency between the lupus nephritis (LN) and non-LN groups in both the dominant and recessive inheritance models. In addition, we identified significant differences in the serum IL-19 levels between the different classes of SLE. Although this study is still at the preliminary stage, the correlations between the IL19 SNP and SLE, and between the

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Systemic lupus erythematosus and infections: Clinical importance of conventional and upcoming biomarkers

Cited by 69 publications

References 48 publications

The role of Fc receptors and complement in autoimmunity

The role of Fc receptors and complement in autoimmunity

Management of infection in systemic lupus erythematosus

Analysis of interleukin 19 serum levels and single nucleotide polymorphisms in systemic lupus erythematosus

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